TY  - JOUR
TI  - Cerebral sinovenous thrombosis in children: clinical
presentation, locations, and acquired and inherited
prothrombotic risk factors
AB  - Background. Cerebral sinovenous thrombosis (CSVT) in children is a rare and life-threatening cerebrovascular
disease. Hence, we evaluated its clinical presentations, inherited and acquired prothrombotic risk factors along
with the accompanying diseases, the thrombosis locations as well as the outcomes of anticoagulant therapy in
children with CSVT.
Methods. The medical records of pediatric CSVT patients treated between January 2011 and September 2018
were analyzed retrospectively.
Results. The study included 29 children, 15 boys (51.7%) and 14 girls (48.3%), with the median age being 11
years (range:3 days-17 years). The most commonly presented complaint in neonates was seizures and in the
non-neonatal age groups was a headache. Also, at least one acquired and/or inherited thrombophilic risk factor
was identified in 89.7% of the patients. The most commonly acquired prothrombotic risk factors along with
the accompanying diseases included infections, central venous catheter, and dehydration, while the most
commonly inherited thrombophilic risk factors included heterozygous factor-V Leiden mutation and elevated
lipoprotein (a). The most common thrombosis location was found to be the transverse sinus. Also, none of the
patients died due to the thrombotic episode. Complications included epilepsy in five patients, hydrocephalus
in one patient, and intracranial hypertension in another patient.
Conclusions. Clinicians need to be well aware of the inherited and acquired prothrombotic risk factors in CSVT.
It should also be kept in mind that at-risk patients may also present with nonspecific signs and symptoms
with no apparent neurological manifestation. The risk of acute complications and long-term sequelae can be
substantially reduced if diagnosed early and initiated with appropriate treatment at the early stages.
AU  - YARAR, Coşkun
AU  - düzenli kar, yeter
AU  - BÖR, Özcan
AU  - Tekin Karacaer, Neslihan
AU  - Özdemir, Zeynep Canan
AU  - ÇARMAN, Kürşat Bora
DO  - 10.24953/turkjped.2021.06.011
PY  - 2021
JO  - Turkish Journal of Pediatrics
VL  - 63
IS  - 6
SN  - 0041-4301
SP  - 1028
EP  - 1037
DB  - TRDizin
UR  - http://search/yayin/detay/518304
ER  -