TY  - JOUR
TI  - The relationship between immature platelet fraction and
severity of acute bronchiolitis
AB  - Background and objectives. Acute bronchiolitis is one of the most common reasons for hospitalization in
infants. Although patients with acute bronchiolitis generally have a good prognosis, death can also occur. In
this study, we evaluate the immature platelet fraction (IPF) as an indicator of the severity of acute bronchiolitis.
Methods. In our study, 179 patients diagnosed with acute bronchiolitis were divided into three groups as mild
(n: 48; 26.8%), moderate (n: 104; 58.10%) and severe (n: 27; 15.1%) bronchiolitis. There were 80 healthy children
in the control group. The diagnostic capacity of IPF and hematological parameters (platelet distribution width
(PDW), mean platelet volume (MPV), white blood cell count (WBC), and platelet count (PLT)) values to predict
severity of acute bronchiolitis was evaluated using receiver operating characteristic (ROC) curves and their
respective areas under the curves (AUCs) calculated with 95% confidence intervals.
Results. The IPF value of patients with acute bronchiolitis was significantly higher than the healthy group (p
< 0.001). In addition, a positive correlation was observed between clinical severity of bronchiolitis and IPF.
The ROC curve analysis indicated that the IPF cut-off point for predicting severity of acute bronchiolitis was
>3.2% (Sensitivity of 84%, specificity of 97%). We found that the AUCs for IPF, MPV, PDW, WBC and PLT were
statistically significant for bronchiolitis relative to the healthy control group. The parameter with the greatest
AUC value was IPF.
Conclusion. The IPF may present for diagnosing and evaluating the clinical severity of acute bronchiolitis in
children.
AU  - Hangul, Melih
AU  - doğan, murat
AU  - Aslaner, Hümeyra
AU  - öztürk, adnan
AU  - kose, mehmet
DO  - 10.24953/turkjped.2021.06.014
PY  - 2021
JO  - Turkish Journal of Pediatrics
VL  - 63
IS  - 6
SN  - 0041-4301
SP  - 1056
EP  - 1063
DB  - TRDizin
UR  - http://search/yayin/detay/518337
ER  -