Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas
Yıl: 2021 Cilt: 37 Sayı: 1 Sayfa Aralığı: 26 - 31 Metin Dili: İngilizce DOI: 10.5146/tjpath.2020.01497 İndeks Tarihi: 14-06-2022
Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas
Öz: Objective: Micropapillary urothelial carcinoma is an aggressive variant of urothelial carcinoma. Evidence suggests that the relationship between
the tumor and inflammatory cells is important in tumor progression and the treatment response. We evaluated the stromal lymphoid response
in micropapillary urothelial carcinomas and compared it with conventional urothelial carcinomas.
Material and Method: Among bladder transurethral resection materials diagnosed as ‘invasive urothelial carcinoma’ between January
2010-March 2017, cases with at least 5% micropapillary urothelial carcinoma were evaluated for age, gender, grade, stage, micropapillary
urothelial carcinoma percentage, presence/percentage of accompanying conventional urothelial carcinoma/urothelial carcinoma variants, in
situ urothelial carcinoma/micropapillary urothelial carcinoma, lymphovascular invasion, necrosis, and stromal lymphoid response. Stromal
lymphoid response was scored as 0-1-2-3. All parameters were evaluated in 50 pure conventional urothelial carcinomas.
Results: Among 47 micropapillary urothelial carcinomas, 41 were male. The mean age was 69 years. pT1/pT2 was 23/24. Six cases were pure
MPUC. Lymphovascular invasion was present in 8, necrosis in 9 cases. Stromal lymphoid response was present and scored as 1-2-3 in 32
micropapillary urothelial carcinomas (68.1%) and 48 conventional urothelial carcinomas (96%). Micropapillary urothelial carcinomas had
significantly higher lymphovascular invasion and pT2 rates and lower stromal lymphoid response.
Conclusion: Low stromal lymphoid response in micropapillary urothelial carcinomas can be responsible for the poor clinical outcome and
impaired response to treatment of these tumors. This is the first study in the English literature to demonstrate a lower stromal lymphoid response
rate in micropapillary urothelial carcinomas compared to conventional urothelial carcinomas.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Hacihasanoglu E, Yucetas U, OKÇU O, BEHZATOĞLU K (2021). Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. , 26 - 31. 10.5146/tjpath.2020.01497 |
| Chicago | Hacihasanoglu Ezgi,Yucetas Ugur,OKÇU Oğuzhan,BEHZATOĞLU Kemal Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. (2021): 26 - 31. 10.5146/tjpath.2020.01497 |
| MLA | Hacihasanoglu Ezgi,Yucetas Ugur,OKÇU Oğuzhan,BEHZATOĞLU Kemal Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. , 2021, ss.26 - 31. 10.5146/tjpath.2020.01497 |
| AMA | Hacihasanoglu E,Yucetas U,OKÇU O,BEHZATOĞLU K Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. . 2021; 26 - 31. 10.5146/tjpath.2020.01497 |
| Vancouver | Hacihasanoglu E,Yucetas U,OKÇU O,BEHZATOĞLU K Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. . 2021; 26 - 31. 10.5146/tjpath.2020.01497 |
| IEEE | Hacihasanoglu E,Yucetas U,OKÇU O,BEHZATOĞLU K "Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas." , ss.26 - 31, 2021. 10.5146/tjpath.2020.01497 |
| ISNAD | Hacihasanoglu, Ezgi vd. "Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas". (2021), 26-31. https://doi.org/10.5146/tjpath.2020.01497 |
| APA | Hacihasanoglu E, Yucetas U, OKÇU O, BEHZATOĞLU K (2021). Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. Türk Patoloji Dergisi, 37(1), 26 - 31. 10.5146/tjpath.2020.01497 |
| Chicago | Hacihasanoglu Ezgi,Yucetas Ugur,OKÇU Oğuzhan,BEHZATOĞLU Kemal Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. Türk Patoloji Dergisi 37, no.1 (2021): 26 - 31. 10.5146/tjpath.2020.01497 |
| MLA | Hacihasanoglu Ezgi,Yucetas Ugur,OKÇU Oğuzhan,BEHZATOĞLU Kemal Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. Türk Patoloji Dergisi, vol.37, no.1, 2021, ss.26 - 31. 10.5146/tjpath.2020.01497 |
| AMA | Hacihasanoglu E,Yucetas U,OKÇU O,BEHZATOĞLU K Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. Türk Patoloji Dergisi. 2021; 37(1): 26 - 31. 10.5146/tjpath.2020.01497 |
| Vancouver | Hacihasanoglu E,Yucetas U,OKÇU O,BEHZATOĞLU K Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas. Türk Patoloji Dergisi. 2021; 37(1): 26 - 31. 10.5146/tjpath.2020.01497 |
| IEEE | Hacihasanoglu E,Yucetas U,OKÇU O,BEHZATOĞLU K "Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas." Türk Patoloji Dergisi, 37, ss.26 - 31, 2021. 10.5146/tjpath.2020.01497 |
| ISNAD | Hacihasanoglu, Ezgi vd. "Stromal Lymphoid Response Status in Micropapillary Urothelial Carcinomas Diagnosed in Bladder Transurethral Resections and its Comparison with Conventional Urothelial Carcinomas". Türk Patoloji Dergisi 37/1 (2021), 26-31. https://doi.org/10.5146/tjpath.2020.01497 |
