TY  - JOUR
TI  - Stromal Lymphoid Response Status in Micropapillary 
Urothelial Carcinomas Diagnosed in Bladder 
Transurethral Resections and its Comparison with 
Conventional Urothelial Carcinomas
AB  - Objective: Micropapillary urothelial carcinoma is an aggressive variant of urothelial carcinoma. Evidence suggests that the relationship between 
the tumor and inflammatory cells is important in tumor progression and the treatment response. We evaluated the stromal lymphoid response 
in micropapillary urothelial carcinomas and compared it with conventional urothelial carcinomas. 
Material and Method: Among bladder transurethral resection materials diagnosed as ‘invasive urothelial carcinoma’ between January 
2010-March 2017, cases with at least 5% micropapillary urothelial carcinoma were evaluated for age, gender, grade, stage, micropapillary 
urothelial carcinoma percentage, presence/percentage of accompanying conventional urothelial carcinoma/urothelial carcinoma variants, in 
situ urothelial carcinoma/micropapillary urothelial carcinoma, lymphovascular invasion, necrosis, and stromal lymphoid response. Stromal 
lymphoid response was scored as 0-1-2-3. All parameters were evaluated in 50 pure conventional urothelial carcinomas. 
Results: Among 47 micropapillary urothelial carcinomas, 41 were male. The mean age was 69 years. pT1/pT2 was 23/24. Six cases were pure 
MPUC. Lymphovascular invasion was present in 8, necrosis in 9 cases. Stromal lymphoid response was present and scored as 1-2-3 in 32 
micropapillary urothelial carcinomas (68.1%) and 48 conventional urothelial carcinomas (96%). Micropapillary urothelial carcinomas had 
significantly higher lymphovascular invasion and pT2 rates and lower stromal lymphoid response. 
Conclusion: Low stromal lymphoid response in micropapillary urothelial carcinomas can be responsible for the poor clinical outcome and 
impaired response to treatment of these tumors. This is the first study in the English literature to demonstrate a lower stromal lymphoid response 
rate in micropapillary urothelial carcinomas compared to conventional urothelial carcinomas.
AU  - BEHZATOĞLU, Kemal
AU  - OKÇU, Oğuzhan
AU  - Hacihasanoglu, Ezgi
AU  - Yucetas, Ugur
DO  - 10.5146/tjpath.2020.01497
PY  - 2021
JO  - Türk Patoloji Dergisi
VL  - 37
IS  - 1
SN  - 1018-5615
SP  - 26
EP  - 31
DB  - TRDizin
UR  - http://search/yayin/detay/518695
ER  -