Ground Glass-Like Inclusions: Associated with Liver Toxicity
Yıl: 2021 Cilt: 37 Sayı: 1 Sayfa Aralığı: 51 - 55 Metin Dili: İngilizce DOI: 10.5146/tjpath.2020.01510 İndeks Tarihi: 14-06-2022
Ground Glass-Like Inclusions: Associated with Liver Toxicity
Öz: Objective: The etiology of ground glass-like inclusions is heterogenous and the pathology has been described in various conditions including
HBV infection, Lafora’s disease, fibrinogen storage disease, type IV glycogenosis, and alcohol reversion therapy. Similar ground glass-like
inclusions are also associated with immunosuppressed conditions and multiple medications, for which the clinical significance is still unclear.
Additional cases, some with previously unreported unique etiologies, and their follow-up were described in this study.
Materials and Methods: Eleven cases were examined between 2008 and 2019 for this study. The clinical data and histologic slides were reviewed.
All of the cases were negative for Hepatitis B virus. None of the patients declared alcohol intake or a history of epilepsy.
Results: Liver histology showed mild lobular inflammation in most of the cases (72%). Ground glass-like hepatocytes were distributed in the
patchy-panlobular, periportal, and centrizonal pattern at 55%, 27%, and 18%, respectively. Clinical history revealed medication use in nine (82%)
patients including NSAIDs, steroids, and chemotherapy. Ground glass-like inclusions were related to herbal toxicity in two of the patients. Liver
function tests were elevated in all of the cases. Follow-up data revealed four patients with malignancy who died of their cancer. Seven patients
showed resolution of elevated liver enzymes with a median follow-up period of 37 months (range 7-132 months).
Conclusions: Medication is the most relevant etiology for the development of these inclusions. Ground glass-like inclusions may also seen in
herbal toxicity. Transplantation was not an etiologic factor in our patients. Most of the patients displayed an indolent course with resolution of
the elevated transaminases.
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APA | Deniz K (2021). Ground Glass-Like Inclusions: Associated with Liver Toxicity. , 51 - 55. 10.5146/tjpath.2020.01510 |
Chicago | Deniz Kemal Ground Glass-Like Inclusions: Associated with Liver Toxicity. (2021): 51 - 55. 10.5146/tjpath.2020.01510 |
MLA | Deniz Kemal Ground Glass-Like Inclusions: Associated with Liver Toxicity. , 2021, ss.51 - 55. 10.5146/tjpath.2020.01510 |
AMA | Deniz K Ground Glass-Like Inclusions: Associated with Liver Toxicity. . 2021; 51 - 55. 10.5146/tjpath.2020.01510 |
Vancouver | Deniz K Ground Glass-Like Inclusions: Associated with Liver Toxicity. . 2021; 51 - 55. 10.5146/tjpath.2020.01510 |
IEEE | Deniz K "Ground Glass-Like Inclusions: Associated with Liver Toxicity." , ss.51 - 55, 2021. 10.5146/tjpath.2020.01510 |
ISNAD | Deniz, Kemal. "Ground Glass-Like Inclusions: Associated with Liver Toxicity". (2021), 51-55. https://doi.org/10.5146/tjpath.2020.01510 |
APA | Deniz K (2021). Ground Glass-Like Inclusions: Associated with Liver Toxicity. Türk Patoloji Dergisi, 37(1), 51 - 55. 10.5146/tjpath.2020.01510 |
Chicago | Deniz Kemal Ground Glass-Like Inclusions: Associated with Liver Toxicity. Türk Patoloji Dergisi 37, no.1 (2021): 51 - 55. 10.5146/tjpath.2020.01510 |
MLA | Deniz Kemal Ground Glass-Like Inclusions: Associated with Liver Toxicity. Türk Patoloji Dergisi, vol.37, no.1, 2021, ss.51 - 55. 10.5146/tjpath.2020.01510 |
AMA | Deniz K Ground Glass-Like Inclusions: Associated with Liver Toxicity. Türk Patoloji Dergisi. 2021; 37(1): 51 - 55. 10.5146/tjpath.2020.01510 |
Vancouver | Deniz K Ground Glass-Like Inclusions: Associated with Liver Toxicity. Türk Patoloji Dergisi. 2021; 37(1): 51 - 55. 10.5146/tjpath.2020.01510 |
IEEE | Deniz K "Ground Glass-Like Inclusions: Associated with Liver Toxicity." Türk Patoloji Dergisi, 37, ss.51 - 55, 2021. 10.5146/tjpath.2020.01510 |
ISNAD | Deniz, Kemal. "Ground Glass-Like Inclusions: Associated with Liver Toxicity". Türk Patoloji Dergisi 37/1 (2021), 51-55. https://doi.org/10.5146/tjpath.2020.01510 |