Yıl: 2021 Cilt: 37 Sayı: 1 Sayfa Aralığı: 63 - 66 Metin Dili: İngilizce DOI: 10.5146/tjpath.2020.01500 İndeks Tarihi: 14-06-2022

IgG4-Related Disease of the Ovary

Öz:
Immunoglobulin G4-related disease is characterized by dense fibrosis, obliterative phlebitis, and lymphoplasmacytic infiltration that contains abundant IgG4 positive plasma cells. It causes tumefactive lesions in the involved organs and is most commonly seen in the salivary glands, pancreas, and retroperitoneum. Ovarian involvement has been reported in only two cases. In our case, a 58-year-old female patient presented with abdominal distention and pain. Pelvic computed tomography revealed a soft tissue lesion compatible with the omental cake, several intraabdominal implants, and bilateral adnexal fullness. A laparotomy was performed under suspicion of peritoneal carcinomatosis secondary to bilateral adnexal mass. In the histopathologic examination, abundant lymphoplasmacytic infiltration and dense fibrosis were observed in both ovaries and the peritoneum. In the areas of greatest density, the density of IgG4-positive plasma cells was found to range from 40 to 50 per high-power field. The patient was accepted as suffering from probable IgG4-related disease because of the bilateral involvement of the ovaries and the histopathological findings. In conclusion, we present this case to draw attention to the fact that IgG4-related disease can also be seen in the ovary.
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  • 1. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med. 2012;366:539-51.
  • 2. Hamano H, Kawa S, Horiuchi A,Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K. High Serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732-8.
  • 3. Zen Y, Harada K, Sasaki M, Sato Y, Tsuneyama K, Haratake J, Kurumaya H, Katayanagi K, Masuda S, Niwa H, Morimoto H, Miwa A, Uchiyama A, Portmann BC, Nakanuma Y. IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: Do they belong to a spectrum of sclerosing pancreatitis? Am J Surg Pathol. 2004;28:1193-203.
  • 4. Cheuk W, Yuen HK, Chu SY, Chiu EK, Lam LK, Chan JK. Lymphadenopathy of IgG4 related sclerosing disease. Am J Surg Pathol. 2008;32:671-81.
  • 5. Zen Y, Onodera M, Inoue D, Kitao A, Matsui O, Nohara T, Namiki M, Kasashima S, Kawashima A, Matsumoto Y, Katayanagi K, Murata T, Ishizawa S, Hosaka N, Kuriki K, Nakanuma Y. Retroperitoneal fibrosis: A clinicopathologic study with respect to immunoglobulin G4. Am J SurgPathol. 2009;33:1833-9.
  • 6. Chen TS, Montgomery EA. Are tumefactive lesions classified as sclerosing mesenteritis a subset of IgG4-related sclerosing disorders? J Clin Pathol. 2008;6:1093-7.
  • 7. Kitagawa S, Zen Y, Harada K, Sasaki M, Sato Y, Minato H, Watanabe K, Kurumaya H, Katayanagi K, Masuda S, Niwa H, Tsuneyama K, Saito K, Haratake J, Takagawa K, Nakanuma Y. Abundant IgG4- positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner’s tumor). Am J Surg Pathol. 2005;29:783-91.
  • 8. Hennessey JV. Riedel’s thyroiditis: A clinical review. J Clin Endocrinol Metab. 2011;96:3031-41.
  • 9. Ohkubo H, Miyazaki M, Oguri T, Arakawa A, Kobashi Y, Niimi A. A rare case of IgG4-related disease involving the uterus. Rheumatology. 2015;54:1124-5.
  • 10. Maruyama S, Sato Y, Taga A, Emoto I, Shirase T, Haga H. Immunoglobulin G4-related disease presenting as bilateral ovarian masses and mimicking advanced ovarian cancer. J Obstet Gynaecol Res.2016;42:103-8.
  • 11. Sekulic M, Sekulic SP, Movahedi-Lankarani S. IgG4-related disease of the ovary: A first description. Int J Gynecol Pathol. 2016;36:190-4.
  • 12. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25:1181-92.
  • 13. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD). Modern Rheumatology.2011;22:1,21-30.
  • 14. Martinez-Valle F, Orozco-Galvez O, Fernandez-Codina A. Update in ethiopathogeny, diagnosis and treatment of the IgG4 related disease. Med Clin. 2018;151:18-25.
  • 15. Carruthers MN, Khosroshahi A, Augustin T, Deshpande V, Stone JH. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease. Ann Rheum Dis. 2015;74:14-8.
APA Dalar S, Öz F, hasdemir s, Yerci Ö (2021). IgG4-Related Disease of the Ovary. , 63 - 66. 10.5146/tjpath.2020.01500
Chicago Dalar Sevda,Öz Fatma,hasdemir seçil,Yerci Ömer IgG4-Related Disease of the Ovary. (2021): 63 - 66. 10.5146/tjpath.2020.01500
MLA Dalar Sevda,Öz Fatma,hasdemir seçil,Yerci Ömer IgG4-Related Disease of the Ovary. , 2021, ss.63 - 66. 10.5146/tjpath.2020.01500
AMA Dalar S,Öz F,hasdemir s,Yerci Ö IgG4-Related Disease of the Ovary. . 2021; 63 - 66. 10.5146/tjpath.2020.01500
Vancouver Dalar S,Öz F,hasdemir s,Yerci Ö IgG4-Related Disease of the Ovary. . 2021; 63 - 66. 10.5146/tjpath.2020.01500
IEEE Dalar S,Öz F,hasdemir s,Yerci Ö "IgG4-Related Disease of the Ovary." , ss.63 - 66, 2021. 10.5146/tjpath.2020.01500
ISNAD Dalar, Sevda vd. "IgG4-Related Disease of the Ovary". (2021), 63-66. https://doi.org/10.5146/tjpath.2020.01500
APA Dalar S, Öz F, hasdemir s, Yerci Ö (2021). IgG4-Related Disease of the Ovary. Türk Patoloji Dergisi, 37(1), 63 - 66. 10.5146/tjpath.2020.01500
Chicago Dalar Sevda,Öz Fatma,hasdemir seçil,Yerci Ömer IgG4-Related Disease of the Ovary. Türk Patoloji Dergisi 37, no.1 (2021): 63 - 66. 10.5146/tjpath.2020.01500
MLA Dalar Sevda,Öz Fatma,hasdemir seçil,Yerci Ömer IgG4-Related Disease of the Ovary. Türk Patoloji Dergisi, vol.37, no.1, 2021, ss.63 - 66. 10.5146/tjpath.2020.01500
AMA Dalar S,Öz F,hasdemir s,Yerci Ö IgG4-Related Disease of the Ovary. Türk Patoloji Dergisi. 2021; 37(1): 63 - 66. 10.5146/tjpath.2020.01500
Vancouver Dalar S,Öz F,hasdemir s,Yerci Ö IgG4-Related Disease of the Ovary. Türk Patoloji Dergisi. 2021; 37(1): 63 - 66. 10.5146/tjpath.2020.01500
IEEE Dalar S,Öz F,hasdemir s,Yerci Ö "IgG4-Related Disease of the Ovary." Türk Patoloji Dergisi, 37, ss.63 - 66, 2021. 10.5146/tjpath.2020.01500
ISNAD Dalar, Sevda vd. "IgG4-Related Disease of the Ovary". Türk Patoloji Dergisi 37/1 (2021), 63-66. https://doi.org/10.5146/tjpath.2020.01500