Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular
Yıl: 2021 Cilt: 51 Sayı: 3 Sayfa Aralığı: 134 - 138 Metin Dili: Türkçe DOI: 10.4274/tjo.galenos.2020.88137 İndeks Tarihi: 14-06-2022
Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular
Öz: Amaç: Pediatrik hematopoetik kök hücre nakli (HKHN) yapılan hastalarda gelişen oküler graft versus host hastalığının (GVHH)
sıklığını ve bulgularını incelemek.
Gereç ve Yöntem: Oküler GVHH tanısı alan pediatrik hastaların dosyaları retrospektif olarak incelendi ve bu hastaların Schirmer
testi, gözyaşı kırılma zamanı ve korneal boyanma derecelenmesini içeren muayene bulguları kaydedildi. Ciddi kuru gözü olan hastalara
topikal siklosporin-A başlandı ve tedavinin sonuçları değerlendirildi.
Bulgular: HKHN yapılan 218 hastadan 51’inde (%23,4) GVHH tespit edildi ve bu hastaların 4’ü takipleri sırasında hayatını kaybetti.
Takip edilen toplam 47 hastanın %63,8’inde kronik oküler GVHH tespit edildi ve 4 hastaya ortanca takip süresi 12,1 ay olmak üzere
ciddi kuru göz bulguları nedeniyle topikal siklosporin-A tedavisi uygulandı. İki hastada ciddi kuru göz bulgularında belirgin bir
düzelme izlenirken, 1 hastada ilaç yan etkisi nedeniyle tedavinin kesilmesi gerekti.
Sonuç: Kronik oküler GVHH, çocuklarda HKHN sonrası gelişen GVHH’nin sık izlenen bir bulgusudur. Bu nedenle, bu hastaların
kuru göz açısından belirli aralıkla muayene edilmesi gerekmektedir.
Anahtar Kelime: Ocular Findings of Pediatric Dry Eye Related to Graft-Versus-Host Disease
Öz: Objectives: To evaluate the frequency and findings of dry eye associated with ocular graft-versus-host disease (GVHD) in pediatric
hematopoietic stem cell transplantation (HSCT) patients.
Materials and Methods: Retrospectively the records of pediatric patients with ocular GVHD were evaluated and ophthalmologic
examination findings as well as Schirmer test results, tear film break-up time, and corneal staining grades were recorded. In severe dry
eye patients topical cyclosporine-A was prescribed and the results were evaluated.
Results: GVHD was detected in 51 (23.4%) of 218 HSCT patients, 4 of whom died during follow-up. Thirty (63.8%) of the remaining
47 patients had chronic ocular GVHD and 4 patients with severe dry eye were treated with topical cyclosporine-A with a median
follow-up of 12.1 months. Severe dry eye symptoms and findings significantly improved in 2 patients. However, 1 patient had to stop
treatment due to side effects.
Conclusion: In children, chronic ocular GVHD is a common finding of GVHD after HSCT. Therefore, these patients should be
examined periodically for dry eye.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Bingol Kiziltunc P, Çelik Büyüktepe T, YALÇINDAĞ F, Ertem M, ince e, İleri T, Atilla H (2021). Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. , 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| Chicago | Bingol Kiziltunc Pinar,Çelik Büyüktepe Tuna,YALÇINDAĞ FATİME NİLÜFER,Ertem Mehmet,ince elif,İleri Talia,Atilla Huban Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. (2021): 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| MLA | Bingol Kiziltunc Pinar,Çelik Büyüktepe Tuna,YALÇINDAĞ FATİME NİLÜFER,Ertem Mehmet,ince elif,İleri Talia,Atilla Huban Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. , 2021, ss.134 - 138. 10.4274/tjo.galenos.2020.88137 |
| AMA | Bingol Kiziltunc P,Çelik Büyüktepe T,YALÇINDAĞ F,Ertem M,ince e,İleri T,Atilla H Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. . 2021; 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| Vancouver | Bingol Kiziltunc P,Çelik Büyüktepe T,YALÇINDAĞ F,Ertem M,ince e,İleri T,Atilla H Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. . 2021; 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| IEEE | Bingol Kiziltunc P,Çelik Büyüktepe T,YALÇINDAĞ F,Ertem M,ince e,İleri T,Atilla H "Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular." , ss.134 - 138, 2021. 10.4274/tjo.galenos.2020.88137 |
| ISNAD | Bingol Kiziltunc, Pinar vd. "Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular". (2021), 134-138. https://doi.org/10.4274/tjo.galenos.2020.88137 |
| APA | Bingol Kiziltunc P, Çelik Büyüktepe T, YALÇINDAĞ F, Ertem M, ince e, İleri T, Atilla H (2021). Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. Türk Oftalmoloji Dergisi, 51(3), 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| Chicago | Bingol Kiziltunc Pinar,Çelik Büyüktepe Tuna,YALÇINDAĞ FATİME NİLÜFER,Ertem Mehmet,ince elif,İleri Talia,Atilla Huban Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. Türk Oftalmoloji Dergisi 51, no.3 (2021): 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| MLA | Bingol Kiziltunc Pinar,Çelik Büyüktepe Tuna,YALÇINDAĞ FATİME NİLÜFER,Ertem Mehmet,ince elif,İleri Talia,Atilla Huban Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. Türk Oftalmoloji Dergisi, vol.51, no.3, 2021, ss.134 - 138. 10.4274/tjo.galenos.2020.88137 |
| AMA | Bingol Kiziltunc P,Çelik Büyüktepe T,YALÇINDAĞ F,Ertem M,ince e,İleri T,Atilla H Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. Türk Oftalmoloji Dergisi. 2021; 51(3): 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| Vancouver | Bingol Kiziltunc P,Çelik Büyüktepe T,YALÇINDAĞ F,Ertem M,ince e,İleri T,Atilla H Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular. Türk Oftalmoloji Dergisi. 2021; 51(3): 134 - 138. 10.4274/tjo.galenos.2020.88137 |
| IEEE | Bingol Kiziltunc P,Çelik Büyüktepe T,YALÇINDAĞ F,Ertem M,ince e,İleri T,Atilla H "Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular." Türk Oftalmoloji Dergisi, 51, ss.134 - 138, 2021. 10.4274/tjo.galenos.2020.88137 |
| ISNAD | Bingol Kiziltunc, Pinar vd. "Graft Versus Host Hastalığı ile İlişkili Pediatrik Kuru Gözde Oküler Bulgular". Türk Oftalmoloji Dergisi 51/3 (2021), 134-138. https://doi.org/10.4274/tjo.galenos.2020.88137 |
