TY  - JOUR
TI  - Evaluation of Prognostic and Predictive Values of 
Hemogram Parameters in Patients with Advanced Stage 
Ovarian Carcinoma
AB  - OBJECTIVE
The aim of the present study was to evaluate the impact of conventional hemogram parameters as a 
biomarker in epithelial ovarian cancer (EOC) patients; and the clinical importance of the difference 
after chemotherapy.
METHODS
We have evaluated the patients with advanced-stage EOC who diagnosed between January 2012 and 
December 2017.
RESULTS
Elevated levels of neutrophils, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio at the 
time of diagnosis were significantly associated with excess amount of ascites. Lower levels of neutrophils 
and hemoglobin (HGB); and higher levels of red cell distribution width (RDW), and RDW/HGB ratio 
were predictors of platinum-sensitivity. In univariate analysis, while decreased mean platelet volume 
(MPV) was associated with longer disease free survival (DFS); elevated RDW, decreased neutrophils, 
MPV, and NLR were effective for better overall survival (OS). In multivariate analysis, platinum sensitivity and MPV were significantly associated with DFS and OS. Importantly, patients with persistently low 
MPV group after chemotherapy had the best OS; while persistently high MPV group had the worst OS.
CONCLUSION
MPV is a marker that can be easily evaluated during complete blood counts, and might be a promising and practical prognostic biomarker in the field of EOC. Hemogram parameters are found useful to 
predict disease properties and survival in EOC.
AU  - oguz soydinc, hilal
AU  - Aydın, Esra
AU  - Paksoy, Nail
AU  - MİNARECİ, Yağmur
AU  - Topuz, Samet
AU  - sözen, hamdullah
AU  - Ferhatoglu, Ferhat
AU  - VATANSEVER, SEZAI
AU  - Bektaş, Erdem
AU  - Karaca, Mert
AU  - Ak, Naziye
AU  - Dogan, Izzet
AU  - Saip, Pınar
DO  - 10.5505/tjo.2021.2882
PY  - 2021
JO  - Türk Onkoloji Dergisi
VL  - 36
IS  - 4
SN  - 1300-7467
SP  - 438
EP  - 445
DB  - TRDizin
UR  - http://search/yayin/detay/518894
ER  -