TY  - JOUR
TI  - Impact of the HEAD-US Scoring System for Observing the 
Protective Effect of Prophylaxis in Hemophilia Patients: 
A Prospective, Multicenter, Observational Study
AB  - Objective: This study aimed to observe the preventive effect of 
prophylactic treatment on joint health in people with hemophilia (PwH) 
and to investigate the importance of integration of ultrasonographic 
examination into clinical and radiological evaluation of the joints.
Materials and Methods: This national, multicenter, prospective, 
observational study included male patients aged ≥6 years with the 
diagnosis of moderate or severe hemophilia A or B from 8 centers 
across Turkey between January 2017 and March 2019. Patients were 
followed for 1 year with 5 visits (baseline and 3rd, 6th, 9th, and 12th 
month visits). The Hemophilia Joint Health Score (HJHS) was used for 
physical examination of joints, the Pettersson scoring system was used 
for radiological assessment, point-of-care (POC) ultrasonography was 
used for bilateral examinations of joints, and the Hemophilia Early 
Arthropathy Detection with Ultrasound (HEAD-US) score was used for 
evaluation of ultrasonography results.
Results: Seventy-three PwH, of whom 62 had hemophilia A and 
11 had hemophilia B, were included and 24.7% had target joints at 
baseline. The HJHS and HEAD-US scores were significantly increased 
at the 12th month in all patients. These scores were also higher in the 
hemophilia A subgroup than the hemophilia B subgroup. However, 
in the childhood group, the increment of scores was not significant. 
The HEAD-US total score was significantly correlated with both the 
HJHS total score and Pettersson total score at baseline and at the 12th
month.
Conclusion: The HEAD-US and HJHS scoring systems are valuable 
tools during follow-up examinations of PwH and they complement 
each other. We suggest that POC ultrasonographic evaluation and the 
HEAD-US scoring system may be integrated into differential diagnosis 
of bleeding and long-term monitoring for joint health as a routine 
procedure.
AU  - Akbas, Tugana
AU  - Arpaci, Taner
AU  - Cevikol, Can
AU  - Demirci, Zühal
AU  - Zulfikar, Bulent
AU  - SEBER, TURGUT
AU  - OGUZ, BERNA
AU  - KOŞUCU, Polat
AU  - Aytac, Selin
AU  - Tüysüz, Gülen
AU  - Tokgöz, Hüseyin
AU  - ŞAŞMAZ, hatice
AU  - Antmen, Bulent
AU  - tamsel, ipek
AU  - Kavakli, Kaan
AU  - BALKAN, CAN
AU  - Koc, Basak
AU  - ÖZBEK, Süha Süreyya
AU  - Kupesiz, Osman Alphan
AU  - Sahin, Fahri
AU  - Sonmez, Mehmet
AU  - BULAKCI, MESUT
AU  - AYDOĞDU, Demet
AU  - ÇALISKAN, ÜMRAN
AU  - Ozkan, Burcu
DO  - 10.4274/tjh.galenos.2021.2020.0717
PY  - 2021
JO  - Turkish Journal of Hematology
VL  - 38
IS  - 2
SN  - 1300-7777
SP  - 101
EP  - 110
DB  - TRDizin
UR  - http://search/yayin/detay/519009
ER  -