A Negative Correlation Between MEFV Mutations
and Allergic Diseases

DUKSAL, Fatma; KILIÇGÜN, Hasan; KURTULGAN, Hande Küçük; YILDIRIM, Malik Ejder

doi:10.4274/jpr.galenos.2021.33407

A Negative Correlation Between MEFV Mutations and Allergic Diseases

Malik Ejder Yıldırım, (Sivas Cumhuriyet Üniversitesi Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Sivas, Türkiye)

Hande Küçük Kurtulgan, (Sivas Cumhuriyet Üniversitesi Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Sivas, Türkiye)

Hasan Kılıçgün, (Erzincan Binali Yıldırım Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Erzincan, Türkiye)

Fatma Duksal (Konya Eğitim ve Araştırma Hastanesi, Çocuk İmmünoloji ve Alerji Kliniği, Konya, Türkiye)

The Journal of Pediatric Research

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Yıl: 2022 Cilt: 9 Sayı: 2 Sayfa Aralığı: 132 - 137 Metin Dili: İngilizce DOI: 10.4274/jpr.galenos.2021.33407 İndeks Tarihi: 15-06-2022

A Negative Correlation Between MEFV Mutations and Allergic Diseases

Öz:

Aim: Atopy is associated with a genetic predisposition to develop allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis. In this study, we aimed to compare the prevalence of Familial Mediterranean Fever (FMF) mutations in asthma and allergic rhinitis patients with controls in the pediatric population and to analyse the positive or negative effect of MEFV mutations in the development of atopy. Materials and Methods: For the detection of FMF mutations, 88 pediatric patients (51 allergic asthma, 17 allergic rhinitis and 20 both asthma and allergic rhinitis cases) and 92 controls were included in our study. Total genomic DNA was extracted from peripheral blood samples using DNA isolation kit. Then, the patient and control groups were screened for MEFV gene mutations by Reverse Hybridization procedure (Strip Assay). Results: There were 9 carriers (heterozygous mutation) in the patient group. The control group had 21 carriers and 1 individual with a compound heterozygous mutation. It was not detected any homozygous mutation in both two groups. The number of individuals with mutation was statistically higher in the control group than in the patients of asthma and allergic rhinitis (p=0.015) and the mutation number (allelic frequency) in the control group was also higher than in the patients (p=0.014). Conclusion: We suggest that FMF mutations are less frequent in allergic rhinitis and asthma cases than in the normal population. Asthma and allergic rhinitis may be more common in individuals without FMF mutation. It can be thought that MEFV gene mutations are effective to prevent allergic reactions on the basis of T helper 2 (Th2) suppression.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILDIRIM M, KURTULGAN H, KILIÇGÜN H, DUKSAL F (2022). A Negative Correlation Between MEFV Mutations and Allergic Diseases. , 132 - 137. 10.4274/jpr.galenos.2021.33407
Chicago	YILDIRIM Malik Ejder,KURTULGAN Hande Küçük,KILIÇGÜN Hasan,DUKSAL Fatma A Negative Correlation Between MEFV Mutations and Allergic Diseases. (2022): 132 - 137. 10.4274/jpr.galenos.2021.33407
MLA	YILDIRIM Malik Ejder,KURTULGAN Hande Küçük,KILIÇGÜN Hasan,DUKSAL Fatma A Negative Correlation Between MEFV Mutations and Allergic Diseases. , 2022, ss.132 - 137. 10.4274/jpr.galenos.2021.33407
AMA	YILDIRIM M,KURTULGAN H,KILIÇGÜN H,DUKSAL F A Negative Correlation Between MEFV Mutations and Allergic Diseases. . 2022; 132 - 137. 10.4274/jpr.galenos.2021.33407
Vancouver	YILDIRIM M,KURTULGAN H,KILIÇGÜN H,DUKSAL F A Negative Correlation Between MEFV Mutations and Allergic Diseases. . 2022; 132 - 137. 10.4274/jpr.galenos.2021.33407
IEEE	YILDIRIM M,KURTULGAN H,KILIÇGÜN H,DUKSAL F "A Negative Correlation Between MEFV Mutations and Allergic Diseases." , ss.132 - 137, 2022. 10.4274/jpr.galenos.2021.33407
ISNAD	YILDIRIM, Malik Ejder vd. "A Negative Correlation Between MEFV Mutations and Allergic Diseases". (2022), 132-137. https://doi.org/10.4274/jpr.galenos.2021.33407

APA	YILDIRIM M, KURTULGAN H, KILIÇGÜN H, DUKSAL F (2022). A Negative Correlation Between MEFV Mutations and Allergic Diseases. The Journal of Pediatric Research, 9(2), 132 - 137. 10.4274/jpr.galenos.2021.33407
Chicago	YILDIRIM Malik Ejder,KURTULGAN Hande Küçük,KILIÇGÜN Hasan,DUKSAL Fatma A Negative Correlation Between MEFV Mutations and Allergic Diseases. The Journal of Pediatric Research 9, no.2 (2022): 132 - 137. 10.4274/jpr.galenos.2021.33407
MLA	YILDIRIM Malik Ejder,KURTULGAN Hande Küçük,KILIÇGÜN Hasan,DUKSAL Fatma A Negative Correlation Between MEFV Mutations and Allergic Diseases. The Journal of Pediatric Research, vol.9, no.2, 2022, ss.132 - 137. 10.4274/jpr.galenos.2021.33407
AMA	YILDIRIM M,KURTULGAN H,KILIÇGÜN H,DUKSAL F A Negative Correlation Between MEFV Mutations and Allergic Diseases. The Journal of Pediatric Research. 2022; 9(2): 132 - 137. 10.4274/jpr.galenos.2021.33407
Vancouver	YILDIRIM M,KURTULGAN H,KILIÇGÜN H,DUKSAL F A Negative Correlation Between MEFV Mutations and Allergic Diseases. The Journal of Pediatric Research. 2022; 9(2): 132 - 137. 10.4274/jpr.galenos.2021.33407
IEEE	YILDIRIM M,KURTULGAN H,KILIÇGÜN H,DUKSAL F "A Negative Correlation Between MEFV Mutations and Allergic Diseases." The Journal of Pediatric Research, 9, ss.132 - 137, 2022. 10.4274/jpr.galenos.2021.33407
ISNAD	YILDIRIM, Malik Ejder vd. "A Negative Correlation Between MEFV Mutations and Allergic Diseases". The Journal of Pediatric Research 9/2 (2022), 132-137. https://doi.org/10.4274/jpr.galenos.2021.33407