Skualen: Biyolojik Etkileri ve Uygulama Alanları:
Geleneksel Derleme

Önder, Alev; Çınar, Ahsen sevde; YILMAZ, OZGE

doi:10.5336/jtracom.2021-84639

Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme

Ahsen ÇINAR, (Lokman Hekim Üniversitesi, Eczacılık Fakültesi, Farmakognozi/Farmasötik Botanik Ana Bilim Dalı, Ankara, Türkiye)

Özge YILMAZ, (Ankara Üniversitesi, Eczacılık Fakültesi, Farmakognozi Ana Bilim Dalı, Ankara, Türkiye)

Alev ÖNDER (Ankara Üniversitesi, Eczacılık Fakültesi, Farmakognozi Ana Bilim Dalı, Ankara, Türkiye)

Geleneksel ve Tamamlayıcı Tıp Dergisi

10 4

Yıl: 2021 Cilt: 4 Sayı: 3 Sayfa Aralığı: 415 - 425 Metin Dili: Türkçe DOI: 10.5336/jtracom.2021-84639 İndeks Tarihi: 15-06-2022

Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme

Öz:

Doğal kaynaklardan elde edilen ham maddeler; fitokimyasal yapıları ve biyolojik aktiviteleri ile her zaman ilgi çekici olmuştur. Bu ham maddeler, hem hayvanlardan hem de bitkilerden elde edilmekte olup, farklı yapı ve özellikte olmaktadır. Triterpenler de doğada bulunan önemli bir grup sekonder bileşiklerdir. Triterpen yapısında olan “skualen”; insanlar, hayvanlar ve bitkiler tarafından sentezlenebilen biyosentetik bir ara üründür. Skualen, yapısal olarak 6 izoprenmolekülünden oluşan ve 6 çifte bağı bulunan, 30 karbonlu doymamış bir hidrokarbon, izoprenoit yapısına sahip, triterpenler sınıfında yer alan lipfilik bir biyomolekül, kokusuz, renksiz sıvı bir yağ olarak tanımlanmaktadır. Bu bileşik, ilk defa, Squalidae familyasına ait bir köpek balığının karaciğer yağından izole edildiği için, familyasına atfen “Skualen” ismini almıştır. Daha sonraları pek çok bitkide de bulunduğu tespit edilmiştir. Hem doğal hem de sentetik yöntemlerle üretilen bu metabolit, sahip olduğu önemli etkiler sebebiyle özellikle kozmetik, ilaç ve diğer farmasötik alanlarda oldukça yaygın kullanılmaktadır. Skualen, emilim ve dağılım veriminin yüksek olması, farklı yollarla uygulandığı zaman vücut tarafından iyi tolere edilebilmesi, toksisite profilinin güvenilir olması sebebiyle farklı alanlarda ve birden fazla uygulama yöntemine sahiptir. Özellikle terapötik uygulamalarda farklı şekillerde kullanımı bulunan bu bileşiğin, tarihçesi, elde edildiği kaynakları, etkileri ve kullanım alanları, bu derleme ile birlikte değerlendirilmiş olup; detaylı literatür incelemesinin ardından kapsamlı bir şekilde sunulmuştur. Bu bilgiler ışığında, skualen hakkında genel bilgilerin yanı sıra kozmetik ve farmasötik alanda kullanımına ve üretimine yönelik tüm bilgiler, bu derlemede sunulacak ve böylece bu konuya dair yeni bir pencere açılacaktır

Anahtar Kelime:

Squalene: Biological Effects and Applications: Traditional Review

Öz:

Raw materials obtained from natural resources have always been fascinating with their phytochemical structures and biological activities. These raw materials are obtained from animals and plants and have different forms and properties. Triterpenes are an important group of secondary compounds found in nature. Squalene, a triterpene structure, is a biosynthetic intermediate that humans, animals, and plants can synthesize. Squalene is defined as a 30-carbon unsaturated hydrocarbon with six double bonds, structurally composed of 6 isoprene molecules and a lipophilic biomolecule with an isoprenoid structure. It is an odorless, colorless liquid oil. Because this compound was first isolated from the shark's liver oil belonging to the Squalidae family, it was named "Squalene" as a reference to its family. The squalene, produced by both natural and synthetic methods, is widely used in cosmetics, medicine, and other pharmaceutical fields due to its important effects. Squalene has more than one application method in different areas due to its high absorption and distribution efficiency, well tolerated by the body when applied in different ways, and its reliable toxicity profile. In this review, this compound's history, sources, effects, and usages, especially in therapeutic applications, have been evaluated and debated comprehensively after a detailed literature screening. In light of this information and general information about squalene, all data about its use and production in cosmetics and pharmaceutical fields will be presented in this review, thus opening a new window on this subject.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Çınar A, YILMAZ O, Önder A (2021). Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. , 415 - 425. 10.5336/jtracom.2021-84639
Chicago	Çınar Ahsen sevde,YILMAZ OZGE,Önder Alev Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. (2021): 415 - 425. 10.5336/jtracom.2021-84639
MLA	Çınar Ahsen sevde,YILMAZ OZGE,Önder Alev Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. , 2021, ss.415 - 425. 10.5336/jtracom.2021-84639
AMA	Çınar A,YILMAZ O,Önder A Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. . 2021; 415 - 425. 10.5336/jtracom.2021-84639
Vancouver	Çınar A,YILMAZ O,Önder A Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. . 2021; 415 - 425. 10.5336/jtracom.2021-84639
IEEE	Çınar A,YILMAZ O,Önder A "Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme." , ss.415 - 425, 2021. 10.5336/jtracom.2021-84639
ISNAD	Çınar, Ahsen sevde vd. "Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme". (2021), 415-425. https://doi.org/10.5336/jtracom.2021-84639

APA	Çınar A, YILMAZ O, Önder A (2021). Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. Geleneksel ve Tamamlayıcı Tıp Dergisi, 4(3), 415 - 425. 10.5336/jtracom.2021-84639
Chicago	Çınar Ahsen sevde,YILMAZ OZGE,Önder Alev Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. Geleneksel ve Tamamlayıcı Tıp Dergisi 4, no.3 (2021): 415 - 425. 10.5336/jtracom.2021-84639
MLA	Çınar Ahsen sevde,YILMAZ OZGE,Önder Alev Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. Geleneksel ve Tamamlayıcı Tıp Dergisi, vol.4, no.3, 2021, ss.415 - 425. 10.5336/jtracom.2021-84639
AMA	Çınar A,YILMAZ O,Önder A Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. Geleneksel ve Tamamlayıcı Tıp Dergisi. 2021; 4(3): 415 - 425. 10.5336/jtracom.2021-84639
Vancouver	Çınar A,YILMAZ O,Önder A Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme. Geleneksel ve Tamamlayıcı Tıp Dergisi. 2021; 4(3): 415 - 425. 10.5336/jtracom.2021-84639
IEEE	Çınar A,YILMAZ O,Önder A "Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme." Geleneksel ve Tamamlayıcı Tıp Dergisi, 4, ss.415 - 425, 2021. 10.5336/jtracom.2021-84639
ISNAD	Çınar, Ahsen sevde vd. "Skualen: Biyolojik Etkileri ve Uygulama Alanları: Geleneksel Derleme". Geleneksel ve Tamamlayıcı Tıp Dergisi 4/3 (2021), 415-425. https://doi.org/10.5336/jtracom.2021-84639