TY  - JOUR
TI  - Evaluation of CD47 Expression in Solid Pancreatic Tumors
Diagnosed with Endosonography Guided Fine Needle Aspiration
Biopsy
AB  - Background: CD47, which is also known as integrin-associated protein, is a membrane protein of the immunoglobulin superfamily.
Its expression was shown to be elevated in hematologic and many solid organ malignancies like pancreatic tumors.
Materials and Methods: The materials of 80 patients diagnosed with endosonography (EUS)-guided fine needle aspiration biopsy
(FNAB) and 42 patients diagnosed after resection were evaluated retrospectively. EUS guided FNAB specimens of all cases and
slides prepared from blocks that had been selected from the subsequently obtained resection materials were stained with CD47
immunohistochemical staining. According to the CD47 expression level, it was divided into two groups as low and high, and the
results were compared with clinicopathological and prognostic factors.
Results: Eighty patients (male=36, female=44, mean age=61.32 years) were included in our study. In 80 EUS biopsy material, 53
(66.75%) cases were diagnosed with adenocarcinoma and this diagnosis was confirmed in resected patients. We found that 32 of 80
patients who underwent EUS-guided FNAB and 32 of those who underwent resection had positive staining with CD47. Considering
high and low staining levels with CD47, our study showed a significant difference between high CD47 expression and disease-free
survival in resection materials (p<0.005), but did not find a significant relationship between other clinicopathological prognostic
factors.
Conclusion: Although high CD47 expression levels were not detected in most EUS biopsy samples, it was observed that high CD47
expression had a negative prognostic effect on disease free survival
AU  - GÜCİN, Zuhal
AU  - çoban, ganime
AU  - Arici, Dilek Sema
AU  - ŞENTÜRK, Hakan
AU  - Sahin, Nurhan
AU  - ünver, nurcan
DO  - 10.4274/hamidiyemedj.galenos.2022.92486
PY  - 2022
JO  - Hamidiye Medical Journal 
VL  - 3
IS  - 1
SN  - 2718-0956
SP  - 46
EP  - 53
DB  - TRDizin
UR  - http://search/yayin/detay/519866
ER  -