TY  - JOUR
TI  - Protective effect of melatonin on cisplatin-induced liver injury in rats
AB  - Purpose: We aimed to evaluate the protective effect of
melatonin (Mel) on experimental hepatatoxicity induced
by cisplatin (Cis).
Materials and Methods: A total of 40 Wistar Albino rats
were used. Control group (n = 10) daily 0.1 mg / kg
isotonic solution (intraperitoneal) i.p. was administered.
Cis group (n = 10) was given a single dose of i.p. Cis (7
mg/kg) was administered. Melatonin (Mel) group (n = 10)
daily i.p. Mel (10 mg / kg) was administered. Cis + Mel
group (n = 10) daily i.p. Mel (10 mg / kg) + single dose i.p.
Cis (7mg / kg) was administered. On the 8th day of the
experiment, liver tissues of rats were collected
histologically and immunohistochemically for tumor
necrosis factor-α (TNF-α) analysis. Analyzes were
performed for the levels of Alanine aminotransferase
(ALT), aspartate aminotransferase (AST), Lactate
dehydrogenase (LDH), and albumin for liver function
from the serum obtained from the blood.
Results: It was observed that liver tissue histopathological
score and TNF-α immunoreactivity increased significantly
with cisplatin administration compared to the control
group. We found that the histopathological score and
TNF-α immunoreactivity were decreased in the group
treated with melatonin, and the liver function enzymes
ALT, AST, and LDH were significantly decreased
compared to the cisplatin group. Albumin level, on the
other hand, showed a significant improvement in the
group treated with melatonin.
Conclusion: Melatonin may play a protective role in
hepatotoxicity caused by cisplatin by reducing
inflammation and preventing the increase in liver enzymes.
AU  - KULOGLU, NURHAN
AU  - KARABULUT, DERYA
AU  - AKİN, Ali Tuğrul
AU  - CEYLAN, TAYFUN
AU  - Ünsal, Murat
AU  - OZTURK, Emel
AU  - KAYMAK, EMIN
AU  - yakan, birkan
DO  - 10.17826/cumj.1029473
PY  - 2022
JO  - Cukurova Medical Journal
VL  - 47
IS  - 1
SN  - 2602-3032
SP  - 250
EP  - 258
DB  - TRDizin
UR  - http://search/yayin/detay/519940
ER  -