Relationship between growth hormone levels and ovarian reserves

Aslan, Kiper; kosan, bahadir; Düzok, Nergis; Kasapoğlu, Işıl; Uncu, Gürkan

doi:10.17826/cumj.1024989

Relationship between growth hormone levels and ovarian reserves

Nergis DUZOK, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Kiper Aslan, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Bahadir KOSAN, (Düzce Atatürk Devlet Hastanesi, Kadın Hastalıkları ve Doğum Bölümü, Düzce, Türkiye)

Işıl Kasapoğlu, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Gürkan Uncu (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Cukurova Medical Journal

3 1

Yıl: 2022 Cilt: 47 Sayı: 1 Sayfa Aralığı: 275 - 282 Metin Dili: İngilizce DOI: 10.17826/cumj.1024989 İndeks Tarihi: 29-07-2022

Relationship between growth hormone levels and ovarian reserves

Öz:

Purpose: The aim of this study was to investigate the relationship between serum anti mullerian hormone levels and serum growth hormone levels in patients with diminished ovarian reserve and unexplained infertility who are planned for in vitro fertilization. Materials and Methods: This prospective cohort study includes 154 women and comprises three study groups which include infertile women with diminished ovarian reserve (Group I), women with unexplained infertility (Group II) and healthy women (Group III) as control group. Prospectively recorded patient data comprehended age, body mass index (BMI), antral follicle count (AFC), gravidity and parity, education, occupation, smoking and alcohol use, and laboratory results (Anti-Mullerian hormone (AMH), Growth Hormone (GH), Follicle-Stimulating hormone, Luteinizing Hormone and Estradiol). Results: The study population consisted of 154 subjects, 52 in Group-I, 52 in Group-II, and 50 in Group-III. The mean women age was higher in DOR group than the other two groups (Respectively with quartiles; 35.5(25-40), 29.5(20-38), 33(19-39)). The other demographic parameters were similar between the groups. Median serum AMH levels was lower in DOR group. Growth hormone levels were similar between the groups.. Conclusion: Our results show that growth hormone has no relationship between ovarian reserve markers. Although lack of relation with ovarian reserve, it’s widely known that GH plays major role in granulosa cell function.

Anahtar Kelime: İnfertility Diminished Ovarian Reserve Anti-Mullerian Hormone Ovarian Function Growth Hormone

Büyüme hormonu seviyeleri ile over rezervleri arasındaki ilişki

Öz:

Amaç: Bu çalışmanın amacı düşük over rezervi ve açıklanamayan infertilite sebebi ile in-vitro fertilizasyon uygulanacak hastalarda serum Anti-Mulleryen hormon seviyeleri ile büyüme hormonu seviyeleri arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Bu prospektif kohort çalışması 154 kadını içermektedir. Kadınlar üç ana grup altında incelenmiştir. Grup 1; düşük over rezervi (DOR) nedeni ile, Grup-2 ise açıklanamayan infertilite nedeni ile IVF-ICSI (in vitro fertilizasyon, intrasitoplazmik sperm enjeksiyonu) tedavisi uygulanan kadınlardan, Grup-3 ise sağlıklı kadınlardan oluşmaktadır. Hasta verileri prospektif olarak kaydedilmiş olup, yaş vücut kitle indeksi, antral folikül sayısı, gravida, parite, eğitim, meslek, sigara ve alkol kullanımı ve laboratuvar sonuçları (anti-mullerian hormon (AMH), Büyüme hormonu (GH), folikül sitmulan hormon, luteinizan hormon ve estradiol). Bulgular: 154 kadından oluşan çalışma popülasyonu; Grup-1 de 52, Grup-2 de 52 ve Grup-3 de 50 kadın olmak üzere gruplandırılmıştır. Ortalama kadın yaşı Grup-1 de diğer iki gruba göre daha yüksek bulunmuştur (Sırasıyla, medyan ve çeyrek değerleri ile, 35.5 (25-40), 29.5 (20-38), 33 (19-39). Diğer demografik veriler her üç grup arasında benzer bulunurken, serum AMH medyan değerleri Grup-1 de daha düşük bulunmuş ancak büyüme hormon seviyeleri üç grup arasında benzer olarak saptanmıştır. Sonuç: Bu çalışma, serum büyüme hormonu ve over rezerv belirteçleri arasında herhangi bir korelasyon olmadığını göstermiştir. Her ne kadar over rezervi ile GH arasında korelasyon gözlenmese de büyüme hormonunun granuloza hücre fonksiyonlarında önemli rolü olduğu unutulmamalıdır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Düzok N, Aslan K, kosan b, Kasapoğlu I, Uncu G (2022). Relationship between growth hormone levels and ovarian reserves. , 275 - 282. 10.17826/cumj.1024989
Chicago	Düzok Nergis,Aslan Kiper,kosan bahadir,Kasapoğlu Işıl,Uncu Gürkan Relationship between growth hormone levels and ovarian reserves. (2022): 275 - 282. 10.17826/cumj.1024989
MLA	Düzok Nergis,Aslan Kiper,kosan bahadir,Kasapoğlu Işıl,Uncu Gürkan Relationship between growth hormone levels and ovarian reserves. , 2022, ss.275 - 282. 10.17826/cumj.1024989
AMA	Düzok N,Aslan K,kosan b,Kasapoğlu I,Uncu G Relationship between growth hormone levels and ovarian reserves. . 2022; 275 - 282. 10.17826/cumj.1024989
Vancouver	Düzok N,Aslan K,kosan b,Kasapoğlu I,Uncu G Relationship between growth hormone levels and ovarian reserves. . 2022; 275 - 282. 10.17826/cumj.1024989
IEEE	Düzok N,Aslan K,kosan b,Kasapoğlu I,Uncu G "Relationship between growth hormone levels and ovarian reserves." , ss.275 - 282, 2022. 10.17826/cumj.1024989
ISNAD	Düzok, Nergis vd. "Relationship between growth hormone levels and ovarian reserves". (2022), 275-282. https://doi.org/10.17826/cumj.1024989

APA	Düzok N, Aslan K, kosan b, Kasapoğlu I, Uncu G (2022). Relationship between growth hormone levels and ovarian reserves. Cukurova Medical Journal, 47(1), 275 - 282. 10.17826/cumj.1024989
Chicago	Düzok Nergis,Aslan Kiper,kosan bahadir,Kasapoğlu Işıl,Uncu Gürkan Relationship between growth hormone levels and ovarian reserves. Cukurova Medical Journal 47, no.1 (2022): 275 - 282. 10.17826/cumj.1024989
MLA	Düzok Nergis,Aslan Kiper,kosan bahadir,Kasapoğlu Işıl,Uncu Gürkan Relationship between growth hormone levels and ovarian reserves. Cukurova Medical Journal, vol.47, no.1, 2022, ss.275 - 282. 10.17826/cumj.1024989
AMA	Düzok N,Aslan K,kosan b,Kasapoğlu I,Uncu G Relationship between growth hormone levels and ovarian reserves. Cukurova Medical Journal. 2022; 47(1): 275 - 282. 10.17826/cumj.1024989
Vancouver	Düzok N,Aslan K,kosan b,Kasapoğlu I,Uncu G Relationship between growth hormone levels and ovarian reserves. Cukurova Medical Journal. 2022; 47(1): 275 - 282. 10.17826/cumj.1024989
IEEE	Düzok N,Aslan K,kosan b,Kasapoğlu I,Uncu G "Relationship between growth hormone levels and ovarian reserves." Cukurova Medical Journal, 47, ss.275 - 282, 2022. 10.17826/cumj.1024989
ISNAD	Düzok, Nergis vd. "Relationship between growth hormone levels and ovarian reserves". Cukurova Medical Journal 47/1 (2022), 275-282. https://doi.org/10.17826/cumj.1024989