TY  - JOUR
TI  - Evaluation of the Diagnostic Significance of Some Biomarkers
in Pruritic Dermatological Diseases: A Case-Control Study
AB  - Objective: Indolamine-2,3-dioxygenase (IDO), neopterin,
periostin, tenascin-C (TN-C), chitinase-3-like protein 1 (CHI3L1/YKL40) YKL-40 have been previously described as diagnostic markers for a
number of pathologies. The aim of our study is to compare the levels of
some immune system-related biomarkers in itchy dermatological diseases
with healthy people and to evaluate the diagnostic importance of these
markers in dermatological diseases. Material and Methods: Our study
included 55 patients diagnosed with neurodermatitis, generalised pruritus and lichen planus. The control group was composed of 30 healthy
adult volunteers with no history of allergic skin conditions. All participants provided informed consent for the use of their medical data in the
study. The serum samples were centrifuged. Centrifuged samples were
stored at -80 ˚C. IDO, neopterin, periostin, TN-C, YKL-40 levels were
determined by an enzyme-linked immunosorbent assay. The MannWhitney U test, Kruskal-Wallis test, and Conover post-hoc method
were used for statistical analysis. Results: Demographic characteristics were recorded and no statistically significant difference was found
between demographic differences. IDO, neopterin, periostin, TN-C,
YKL-40 levels were higher in patients than in controls (p<0.05). The
Th1/Th2-mediated immune response activation has been observed in allergic skin diseases. A positive correlation was found between all measured parameters (p<0.01). Conclusion: In our study, non-invasive
current biomarkers that can be used in the diagnosis of dermatological
pathologies yielded significant results. We found higher levels of serum
biomarkers in patients compared to controls. It remains uncertain
whether the examined protein is related only to inflammation or is released also as a result of specific biochemical processes due to allergy.
However, these indicators may still have an important place in terms of
early diagnosis.
AU  - ünüvar, songül
AU  - başak türkmen, neşe
AU  - Türkmen, Dursun
AU  - Marsak, Mücahit
AU  - Tanrıverdi, zübeyde
AU  - yüce, hande
DO  - 10.5336/dermato.2021-81122
PY  - 2021
JO  - Türkiye Klinikleri Dermatoloji Dergisi
VL  - 31
IS  - 2
SN  - 2146-9016
SP  - 86
EP  - 92
DB  - TRDizin
UR  - http://search/yayin/detay/520004
ER  -