Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment
Yıl: 2021 Cilt: 67 Sayı: 4 Sayfa Aralığı: 509 - 517 Metin Dili: İngilizce DOI: 10.5606/tftrd.2021.7796 İndeks Tarihi: 16-06-2022
Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment
Öz: Objectives: The aim of this study was to investigate the association of fibromyalgia (FM) syndrome with ankylosing spondylitis (AS) and to
compare the AS patients with and without FM according to the disease activity, clinical and laboratory findings, and response to treatment.
Patients and methods: Between September 2016 and September 2020, a total of 511 patients (312 males, 119 females;
mean age: 43.0±11.2 years; range, 18 to 77 years) who were diagnosed with AS were retrospectively analyzed. Age, sex, disease duration,
disease onset age, and extra-articular findings were recorded. Medical treatments used by the patients for the treatment of AS and FM
were noted. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), human leukocyte antigen-B27 (HLA-B27) status,
and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS) with ESR
(ASDAS-ESR) and ASDAS-CRP values were recorded.
Results: The frequency of FM in AS patients was 23.2%. Totally, 75.4% of the FM patients were female. The HLA-B27 positivity,
extra-articular involvement frequency, disease duration, and acute phase reactants levels were similar between AS patients with and without
FM (p=0.118, p=0.154, p=0.829, p=0.113, and p=0.763, respectively). The AS patients with FM had lower rates of achieving remission or
low disease activity, compared to those without FM. The mean of all three disease activity scores between these two groups was also higher
in the AS patients with FM (p<0.001). The rate of use of biological therapy was significantly higher in the AS patients with FM than those
without FM (p=0.037).
Conclusion: Since the treatment plan of AS is made based on the disease activity scores, unnecessary biological therapy may be initiated for
patients or the biological therapies they use may be switched unnecessarily. Therefore, it should be kept in mind that FM may present with
AS in patients who do not respond to treatment clinically, and this may be misinterpreted as treatment unresponsiveness.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Durmaz Y, İLHANLI İ (2021). Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. , 509 - 517. 10.5606/tftrd.2021.7796 |
| Chicago | Durmaz Yunus,İLHANLI İlker Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. (2021): 509 - 517. 10.5606/tftrd.2021.7796 |
| MLA | Durmaz Yunus,İLHANLI İlker Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. , 2021, ss.509 - 517. 10.5606/tftrd.2021.7796 |
| AMA | Durmaz Y,İLHANLI İ Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. . 2021; 509 - 517. 10.5606/tftrd.2021.7796 |
| Vancouver | Durmaz Y,İLHANLI İ Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. . 2021; 509 - 517. 10.5606/tftrd.2021.7796 |
| IEEE | Durmaz Y,İLHANLI İ "Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment." , ss.509 - 517, 2021. 10.5606/tftrd.2021.7796 |
| ISNAD | Durmaz, Yunus - İLHANLI, İlker. "Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment". (2021), 509-517. https://doi.org/10.5606/tftrd.2021.7796 |
| APA | Durmaz Y, İLHANLI İ (2021). Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. Turkish Journal of Physical Medicine and Rehabilitation, 67(4), 509 - 517. 10.5606/tftrd.2021.7796 |
| Chicago | Durmaz Yunus,İLHANLI İlker Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. Turkish Journal of Physical Medicine and Rehabilitation 67, no.4 (2021): 509 - 517. 10.5606/tftrd.2021.7796 |
| MLA | Durmaz Yunus,İLHANLI İlker Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. Turkish Journal of Physical Medicine and Rehabilitation, vol.67, no.4, 2021, ss.509 - 517. 10.5606/tftrd.2021.7796 |
| AMA | Durmaz Y,İLHANLI İ Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. Turkish Journal of Physical Medicine and Rehabilitation. 2021; 67(4): 509 - 517. 10.5606/tftrd.2021.7796 |
| Vancouver | Durmaz Y,İLHANLI İ Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment. Turkish Journal of Physical Medicine and Rehabilitation. 2021; 67(4): 509 - 517. 10.5606/tftrd.2021.7796 |
| IEEE | Durmaz Y,İLHANLI İ "Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment." Turkish Journal of Physical Medicine and Rehabilitation, 67, ss.509 - 517, 2021. 10.5606/tftrd.2021.7796 |
| ISNAD | Durmaz, Yunus - İLHANLI, İlker. "Comparison of ankylosing spondylitis patients with and without fibromyalgia syndrome according to the disease activation scores and response to treatment". Turkish Journal of Physical Medicine and Rehabilitation 67/4 (2021), 509-517. https://doi.org/10.5606/tftrd.2021.7796 |
