The role of Pentraxin-3 and Angiopoietin-1 in the
inflammation pathway in chronic kidney disease

Kaya, Mervegul; Karataş, Ahmet; Çanakçı, Ebru; cihan, murat

The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease

Murat CİHAN, (Ordu Üniversitesi Eğitim ve Araştırma Hastanesi Tıbbi Biyokimya Anabilim Dalı, Ordu, Türkiye)

Ahmet KARATAŞ, (Ondokuz Mayıs Üniversitesi, Nefroloji Anabilim Dalı, Samsun, Türkiye)

Ebru ÇANAKÇI, (Ordu Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Ordu, Türkiye)

Mervegül KAYA (Ordu Üniversitesi Eğitim ve Araştırma Hastanesi, Aile Hekimliği AD, Ordu, Türkiye)

Annals of Medical Research

2 0

Yıl: 2022 Cilt: 29 Sayı: 3 Sayfa Aralığı: 280 - 285 Metin Dili: İngilizce İndeks Tarihi: 16-06-2022

The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease

Öz:

pathway that have been studied in CKD and other inflammatory diseases. This study aims to investigate the relationship of Pentraxin-3 and Angiopoetin-1 in the inflammation pathway in chronic kidney disease (CKD). Materials and Methods: Our study was planned single-center, prospective, crosssectional study. This study includes 25 healthy volunteers, 29 predialysis cases, 34 cases in routine hemodialysis program.Blood was drawn after 12 hours of fasting. In addition to routine biochemical tests, Pentraxin-3 Angiopoetin-1, 1,25 hydroxy Vitamin D levels were measured. Age and gender parameters, BUN, creatinine, e-GFR values of the cases were recorded. Results: Pentraxin-3 levels were not statistically significant for all three groups (p = 0.993). For angiopoietin-1 levels, statistical significance was found between all three groups (p < 0.001). While 25 hydroxy Vit D levels were not statistically significant between all three groups (p = 0.329), by comparison with 1.25 dihydroxy Vit D levels, a statistically significant difference was found for all three groups (p < 0.001). There was a positive low-level relationship (r = 0.023) between creatine and Pentraxin-3, and this relationship was not statistically significant (p = 0.832). There is a moderate positive correlation (r = 0.593) between creatine and Angiopoietin-1 and this relation is statistically significant (p < 0.001). A simple regression model was established for creatine and angiopoietin-1. Conclusion: Since Pentraxin-3 is accepted as an acute phase reactant in the literature, no significant relationship was found between all groups in our study either. Angiopoietin- 1 levels were found to be increased in CKD cases and we found statistically significant results. Angiopoetin-1 can be considered as a useful biomarker for the follow-up and treatment of CKD.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Chen TK, Knicely DH, Grams ME. Chronic Kidney Disease Diagnosis and Management: A Review. JAMA 2019;322(13):1294- 304
2. Kim SB, Lee KH, Lee JU, Ann HW, Ahn JY, Jeon YD, et al. Long pentraxin 3 as a predictive marker of mortality in severe septic patients who received successful early goal-directed therapy. Yonsei Med J. 2017;58(2):370–9.
3. Haliloglu M, Bilgili B, Bilginer H, Kasapoglu US, Sayan I, Aslan MS, et al. A new scoring system for early diagnosis of ventilator-associated pneumonia: LUPPIS. Arch Med Sci. 2020;16(5):1040–8.
4. Bottazzi B, Garlanda C, Cotena A, Moalli F, Jaillon S, Deban L, The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity. Immunological Reviews 2009; 227(1):9–18.
5. Inforzato A, Reading PC, Barbati E, Bottazzi B, Garlanda C, Mantovani A. The “Sweet” Side of a Long Pentraxin: How Glycosylation Affects Ptx3 Functions in Innate Immunity and Inflammation.Front Immunol 2013;3 Article ID 407. https://doi.org/10.3389/fimmu.2012.00407
6. Latini R, Maggioni AP, Peri G.Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction Circulation 2004;110(16):2349-54.
7. Ozer Balin S, Sagmak Tartar A, Ugur K, Kilinc F, Telo S, Bal A et al. Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection? Int Wound J 2019;16(3):659– 64.
8. Fagiani E, Lorentz P, Kopfstein L, Christofori G.Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis Cancer Res; 71(17); 5717–27.
9. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. 2013;3(1):19-112.
10. David S, John SG, Jefferies HJ ,Sigrist MK , Kumpers P, Kielstein JT et al. Angiopoietin-2 levels predict mortality in CKD patients Nephrol Dial Transplant 2012 (27): 1867–72 doi: 10.1093/ndt/gfr551
11. Anderson CE, Lee Hamm L, Batuman G , Kumbala DR, Chen CS, Kallu SG et al. The association of angiogenic factors and chronic kidney disease BMC Nephrology 2018;19(117):1-8
12. Tsai YC,Lee CS,Chiu YW,Kuo HT,Lee SC,Hwang SJ et al. Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease Sci. Rep 2016; 6, 39400; doi: 10.1038/srep39400
13. Loganathan K, Salem Said E, Winterrowd E, Orebrand M, He L, Vanlandewijck M, et al. (2018) Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice. PLoS ONE 13(1):1-18 e0189433.
14. Fornai F, Carrizzo A, Forte M, Ambrosio M, Damato A, Ferrucci M, et al. The inflammatory protein Pentraxin 3 in cardiovascular disease.Immunity& Ageing. 2016;13(1):5-9 DOI 10.1186/s12979- 016-0080-1
15. Abu Seman N, Witasp A, Mohamud WNW, Anderstam B, Brismar K, Stenvinkel et al Evaluation of the Association of Plasma Pentraxin 3 Levels with Type 2 DiaPbetes and Diabetic Nephropathy in a Malay PopulationJ Diabetes Res. 2013; 2013: 298019.
16. SjöbergB,Qureshi AR, Heimbürger O, Stenvinkel P, Lind L, Larsson A et al. Association between levels of pentraxin 3 and incidence of chronic kidney disease in the elderly J Intern Med. 2016 ; 279(2): 173–9.
17. Ristagno G, Fumagalli F, Bottazzi B, Mantovani A, Olivari D, Novelli D et al.Pentraxin 3 in Cardiovascular DiseaseFront Immunol. 2019; 10: 823. doi: 10.3389/fimmu.2019.00823
18. Dubin R, Shlipak M, Li M, Ix J,H. de Boer I , Jenny N et al.Racial differences in the association of pentraxin-3 with kidney dysfunction: the Multi-Ethnic Study of Atherosclerosis Nephrol Dial Transplant. 2011 Jun; 26(6): 1903–1908. doi: 10.1093/ndt/gfq648
19. Miyamoto T, Rashid Qureshi A, Heimbürger O, Bárány P, Carrero K, Sjöberg B, Lindholm B, Stenvinkel P, Carrero JJ. Inverse relationship between the inflammatory marker pentraxin-3, fat body mass, and abdominal obesity in endstage renal disease. Clin J Am Soc Nephrol. 2011 ;6(12):2785- 91. doi: 10.2215/CJN.02320311. PMID: 22157708; PMCID: PMC3255358.
20. Suliman ME, Yilmaz MI, Carrero JJ, Qureshi AR, Saglam M, Ipcioglu OM, Yenicesu M, Tong M, Heimbürger O, Barany P, Alvestrand A, Lindholm B, Stenvinkel P. Novel links between the long pentraxin 3, endothelial dysfunction, and albuminuria in early and advanced chronic kidney disease. Clin J Am Soc Nephrol. 2008;3(4):976-85. doi: 10.2215/CJN.03960907. Epub 2008 Apr 16. PMID: 18417746; PMCID: PMC2440283.
21. Levin A, Le Barbier M, Er L, Andress D,Sigrist MK, Djurdjev O. Incident isolated 1,25(OH)(2)D(3) deficiency is more common than 25(OH)D deficiency in CKD. Journal of Nephrology. 2012;25(2):204-10. DOI: 10.5301/jn.2011.8429. PMID: 21688248.

APA	cihan m, Karataş A, Çanakçı E, Kaya M (2022). The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. , 280 - 285.
Chicago	cihan murat,Karataş Ahmet,Çanakçı Ebru,Kaya Mervegul The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. (2022): 280 - 285.
MLA	cihan murat,Karataş Ahmet,Çanakçı Ebru,Kaya Mervegul The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. , 2022, ss.280 - 285.
AMA	cihan m,Karataş A,Çanakçı E,Kaya M The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. . 2022; 280 - 285.
Vancouver	cihan m,Karataş A,Çanakçı E,Kaya M The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. . 2022; 280 - 285.
IEEE	cihan m,Karataş A,Çanakçı E,Kaya M "The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease." , ss.280 - 285, 2022.
ISNAD	cihan, murat vd. "The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease". (2022), 280-285.

APA	cihan m, Karataş A, Çanakçı E, Kaya M (2022). The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. Annals of Medical Research, 29(3), 280 - 285.
Chicago	cihan murat,Karataş Ahmet,Çanakçı Ebru,Kaya Mervegul The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. Annals of Medical Research 29, no.3 (2022): 280 - 285.
MLA	cihan murat,Karataş Ahmet,Çanakçı Ebru,Kaya Mervegul The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. Annals of Medical Research, vol.29, no.3, 2022, ss.280 - 285.
AMA	cihan m,Karataş A,Çanakçı E,Kaya M The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. Annals of Medical Research. 2022; 29(3): 280 - 285.
Vancouver	cihan m,Karataş A,Çanakçı E,Kaya M The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease. Annals of Medical Research. 2022; 29(3): 280 - 285.
IEEE	cihan m,Karataş A,Çanakçı E,Kaya M "The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease." Annals of Medical Research, 29, ss.280 - 285, 2022.
ISNAD	cihan, murat vd. "The role of Pentraxin-3 and Angiopoietin-1 in the inflammation pathway in chronic kidney disease". Annals of Medical Research 29/3 (2022), 280-285.