Objective: We compared the first-trimester screening test results and perinatal results of pregnant women to determine the diagnosis of abruptio placentae, one of the essential causes of maternal and fetal mortality and morbidity. Methods: Between 2019 and 2021, 20 pregnant women diagnosed with abruptio placentae in our hospital and 30 pregnant women who did not develop clinical abruptio placentae during their pregnancy in the same period were included in our study. The relationship between the firsttrimester screening test results and the perinatal outcomes of the patients was investigated. Results: No significant differences were found in maternal age, gravida and parity. Significant difference was found in gestational age at birth, being 33±5.1 weeks in the study group and 38.6±1.48 weeks in the control group. No statistical differences were found at PAPP-A or at β-hCG between the groups (p=0.219 and p=0.898, respectively). Nevertheless, a trend of a lower PAPP-A at the study group was noticed (1.03±0.54 MoM vs. 1.28±0.66 MoM). Significant differences were found at fetal birth weight, 1-minute Apgar score and 5-minute Apgar score. When looking at risk factors, no differences between the groups were found at smoking, multiple pregnancy, myoma uteri or diabetes, but preeclampsia and threatened preterm labor were more common at the study group. Conclusion: When we compared the first-trimester serum biomarkers to predict abruptio placentae, we could not find any significant difference between the two groups. To reach a definite conclusion on this issue, more studies with increasing the number of patients are neede