Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery
Yıl: 2022 Cilt: 26 Sayı: 1 Sayfa Aralığı: 210 - 218 Metin Dili: İngilizce DOI: 10.29228/jrp.119 İndeks Tarihi: 17-06-2022
Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery
Öz: The purpose of this work is to develop a biodegradable calcium alginate (Ca-alginate) bead formulation to provide controlled release of l-cysteine (Cys) amino acid for oral drug delivery. Ca-alginate bead formulations were prepared successfully and reproducibly using calcium chloride as a cross-linking agent. The beads were then evaluated in terms of morphology, particle size, swellability, thermal behaviors, encapsulation efficiency, and in-vitro drug release at pH 1.2 and pH 7.4. The size of the beads was measured between 2.230.11 and 2.410.12 mm. In terms of thermal analysis, differential scanning calorimetry was utilized to ensure the encapsulation of Cys into bead formulation. Cys encapsulation was determined as 79.49 %1.12. Swelling index of blank beads were found to be in a range of 0.31-0.35 in HCl solution at pH 1.2; 0.98-1.08 in PBS buffer at pH 7.4. Alginate beads exhibited controlled release, followed the Weibull model which is consistent with the swelling pattern. The physico-chemical properties of the developed formulation indicate that the formulation is suitable for oral Cys delivery.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | ÖZTÜRK K (2022). Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. , 210 - 218. 10.29228/jrp.119 |
Chicago | ÖZTÜRK Kıvılcım Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. (2022): 210 - 218. 10.29228/jrp.119 |
MLA | ÖZTÜRK Kıvılcım Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. , 2022, ss.210 - 218. 10.29228/jrp.119 |
AMA | ÖZTÜRK K Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. . 2022; 210 - 218. 10.29228/jrp.119 |
Vancouver | ÖZTÜRK K Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. . 2022; 210 - 218. 10.29228/jrp.119 |
IEEE | ÖZTÜRK K "Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery." , ss.210 - 218, 2022. 10.29228/jrp.119 |
ISNAD | ÖZTÜRK, Kıvılcım. "Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery". (2022), 210-218. https://doi.org/10.29228/jrp.119 |
APA | ÖZTÜRK K (2022). Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. Journal of research in pharmacy (online), 26(1), 210 - 218. 10.29228/jrp.119 |
Chicago | ÖZTÜRK Kıvılcım Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. Journal of research in pharmacy (online) 26, no.1 (2022): 210 - 218. 10.29228/jrp.119 |
MLA | ÖZTÜRK Kıvılcım Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. Journal of research in pharmacy (online), vol.26, no.1, 2022, ss.210 - 218. 10.29228/jrp.119 |
AMA | ÖZTÜRK K Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. Journal of research in pharmacy (online). 2022; 26(1): 210 - 218. 10.29228/jrp.119 |
Vancouver | ÖZTÜRK K Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery. Journal of research in pharmacy (online). 2022; 26(1): 210 - 218. 10.29228/jrp.119 |
IEEE | ÖZTÜRK K "Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery." Journal of research in pharmacy (online), 26, ss.210 - 218, 2022. 10.29228/jrp.119 |
ISNAD | ÖZTÜRK, Kıvılcım. "Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery". Journal of research in pharmacy (online) 26/1 (2022), 210-218. https://doi.org/10.29228/jrp.119 |