TY  - JOUR
TI  - Development and in-vitro characterization of l-cysteine loaded alginate beads for oral delivery
AB  - The purpose of this work is to develop a biodegradable calcium alginate (Ca-alginate) bead formulation to provide controlled release of l-cysteine (Cys) amino acid for oral drug delivery. Ca-alginate bead formulations were prepared successfully and reproducibly using calcium chloride as a cross-linking agent. The beads were then evaluated in terms of morphology, particle size, swellability, thermal behaviors, encapsulation efficiency, and in-vitro drug release at pH 1.2 and pH 7.4. The size of the beads was measured between 2.230.11 and 2.410.12 mm. In terms of thermal analysis, differential scanning calorimetry was utilized to ensure the encapsulation of Cys into bead formulation. Cys encapsulation was determined as 79.49 %1.12. Swelling index of blank beads were found to be in a range of 0.31-0.35 in HCl solution at pH 1.2; 0.98-1.08 in PBS buffer at pH 7.4. Alginate beads exhibited controlled release, followed the Weibull model which is consistent with the swelling pattern. The physico-chemical properties of the developed formulation indicate that the formulation is suitable for oral Cys delivery.
AU  - ÖZTÜRK, Kıvılcım
DO  - 10.29228/jrp.119
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 1
SN  - 2630-6344
SP  - 210
EP  - 218
DB  - TRDizin
UR  - http://search/yayin/detay/520487
ER  -