Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling
Model Epilepsy

İNANDIKLIOĞLU, NİHAL; Akyuz, Enes; Güleryüz, Naciyenur; KÖKLÜ, Betül; Sahin, Seliha

doi:10.14744/epilepsi.2021.35403

Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy

Nihal İNANDIKLIOĞLU, (Yozgat Bozok Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Yozgat, Türkiye)

Betul KOKLU, (Yozgat Bozok Üniversitesi Tıp Fakültesi, Yozgat, Türkiye)

Seliha SAHIN, (Yozgat Bozok Üniversitesi Tıp Fakültesi, Yozgat, Türkiye)

Naciyenur GULERYUZ, (Yozgat Bozok Üniversitesi Tıp Fakültesi, Yozgat, Türkiye)

ENES AKYÜZ (Yozgat Bozok Üniversitesi Tıp Fakültesi Biyofizik Anabilim Dalı, Yozgat, Türkiye)

Epilepsi

1 0

Yıl: 2021 Cilt: 27 Sayı: 4 Sayfa Aralığı: 205 - 211 Metin Dili: İngilizce DOI: 10.14744/epilepsi.2021.35403 İndeks Tarihi: 17-06-2022

Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy

Öz:

Objectives: Cytokines are thought to be involved in the pathogenesis of many neurological diseases such as epilepsy. It is predicted that ınterleukin (IL)-1β and IL-6 levels in brain tissue are effective in the initiation and maintenance of epileptic seizures. However, there is no study addressing the inflammatory process in the lung in epileptic conditions. It was aimed to contribute to the mechanism of respiratory pathologies accompanying epilepsy in this study. Methods: The chemical pentylenetetrazol (PTZ) has been used to develop epileptic seizures in rats. To examine the effect of seizures on the formation of inflammation in the lung, the expression levels of IL-1β and IL-6 were measured by real-time polymerase chain reaction. Results: We found that the expression levels of IL-6 and IL-1β in the lung tissue of rats in the animal model of epilepsy induced by PTZ increased significantly. In addition, we found that both IL-6 and IL-1β mRNA expression increased at a higher rate in epileptic females than males. Conclusion: This is the first study evaluating the IL-1β and IL-6 expression levels in the lung. Our results support the existence of an inflammatory state in epileptic patients. The significance of our findings will be supported by future studies on pro-inflammatory and anti-inflammatory responses in the lung.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	İNANDIKLIOĞLU N, KÖKLÜ B, Sahin S, Güleryüz N, Akyuz E (2021). Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. , 205 - 211. 10.14744/epilepsi.2021.35403
Chicago	İNANDIKLIOĞLU NİHAL,KÖKLÜ Betül,Sahin Seliha,Güleryüz Naciyenur,Akyuz Enes Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. (2021): 205 - 211. 10.14744/epilepsi.2021.35403
MLA	İNANDIKLIOĞLU NİHAL,KÖKLÜ Betül,Sahin Seliha,Güleryüz Naciyenur,Akyuz Enes Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. , 2021, ss.205 - 211. 10.14744/epilepsi.2021.35403
AMA	İNANDIKLIOĞLU N,KÖKLÜ B,Sahin S,Güleryüz N,Akyuz E Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. . 2021; 205 - 211. 10.14744/epilepsi.2021.35403
Vancouver	İNANDIKLIOĞLU N,KÖKLÜ B,Sahin S,Güleryüz N,Akyuz E Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. . 2021; 205 - 211. 10.14744/epilepsi.2021.35403
IEEE	İNANDIKLIOĞLU N,KÖKLÜ B,Sahin S,Güleryüz N,Akyuz E "Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy." , ss.205 - 211, 2021. 10.14744/epilepsi.2021.35403
ISNAD	İNANDIKLIOĞLU, NİHAL vd. "Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy". (2021), 205-211. https://doi.org/10.14744/epilepsi.2021.35403

APA	İNANDIKLIOĞLU N, KÖKLÜ B, Sahin S, Güleryüz N, Akyuz E (2021). Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. Epilepsi, 27(4), 205 - 211. 10.14744/epilepsi.2021.35403
Chicago	İNANDIKLIOĞLU NİHAL,KÖKLÜ Betül,Sahin Seliha,Güleryüz Naciyenur,Akyuz Enes Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. Epilepsi 27, no.4 (2021): 205 - 211. 10.14744/epilepsi.2021.35403
MLA	İNANDIKLIOĞLU NİHAL,KÖKLÜ Betül,Sahin Seliha,Güleryüz Naciyenur,Akyuz Enes Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. Epilepsi, vol.27, no.4, 2021, ss.205 - 211. 10.14744/epilepsi.2021.35403
AMA	İNANDIKLIOĞLU N,KÖKLÜ B,Sahin S,Güleryüz N,Akyuz E Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. Epilepsi. 2021; 27(4): 205 - 211. 10.14744/epilepsi.2021.35403
Vancouver	İNANDIKLIOĞLU N,KÖKLÜ B,Sahin S,Güleryüz N,Akyuz E Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy. Epilepsi. 2021; 27(4): 205 - 211. 10.14744/epilepsi.2021.35403
IEEE	İNANDIKLIOĞLU N,KÖKLÜ B,Sahin S,Güleryüz N,Akyuz E "Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy." Epilepsi, 27, ss.205 - 211, 2021. 10.14744/epilepsi.2021.35403
ISNAD	İNANDIKLIOĞLU, NİHAL vd. "Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling Model Epilepsy". Epilepsi 27/4 (2021), 205-211. https://doi.org/10.14744/epilepsi.2021.35403