TY  - JOUR
TI  - Expression of Lung IL-1β and IL-6 in Pentylenetetrazol-Kindling
Model Epilepsy
AB  - Objectives: Cytokines are thought to be involved in the pathogenesis of many neurological diseases such as epilepsy. It is predicted that
ınterleukin (IL)-1β and IL-6 levels in brain tissue are effective in the initiation and maintenance of epileptic seizures. However, there is no study
addressing the inflammatory process in the lung in epileptic conditions. It was aimed to contribute to the mechanism of respiratory pathologies
accompanying epilepsy in this study.
Methods: The chemical pentylenetetrazol (PTZ) has been used to develop epileptic seizures in rats. To examine the effect of seizures on the
formation of inflammation in the lung, the expression levels of IL-1β and IL-6 were measured by real-time polymerase chain reaction.
Results: We found that the expression levels of IL-6 and IL-1β in the lung tissue of rats in the animal model of epilepsy induced by PTZ increased
significantly. In addition, we found that both IL-6 and IL-1β mRNA expression increased at a higher rate in epileptic females than males.
Conclusion: This is the first study evaluating the IL-1β and IL-6 expression levels in the lung. Our results support the existence of an inflammatory
state in epileptic patients. The significance of our findings will be supported by future studies on pro-inflammatory and anti-inflammatory
responses in the lung.
AU  - İNANDIKLIOĞLU, NİHAL
AU  - Akyuz, Enes
AU  - Güleryüz, Naciyenur
AU  - KÖKLÜ, Betül
AU  - Sahin, Seliha
DO  - 10.14744/epilepsi.2021.35403
PY  - 2021
JO  - Epilepsi
VL  - 27
IS  - 4
SN  - 1300-7157
SP  - 205
EP  - 211
DB  - TRDizin
UR  - http://search/yayin/detay/520741
ER  -