TY  - JOUR
TI  - Apoptosis Related PDCD4: Promising Novel Biomarker Early Detection of Oral Cancer
AB  - Aim: This study aimed to investigate the potential role of the PDCD4 gene, involved in the progression of the oral potentially malign disorder (OPMD) and oral squamous cell carcinoma cancer (OSCC).
Material and Methods: The study was conducted on saliva and blood samples that were collected from OSCC (n=6), OPMD (n=6) patients, and healthy (n=6) individuals. The expression of PDCD4 was determined by using qRT-PCR. Kruskal Wallis test was performed to estimate the relationship between PDCD4 expression and clinical characteristics of OSCC and OPMD patients. The correlation between PDCD4 expression and patients groups was tested with the Rank Spearman test.
Results: PDCD4 mRNA expression levels were assessed in 6 OSCCs, 6 OPMD patients, and 6 healthy individuals saliva and blood. In both blood and saliva, PDCD4 mRNA expression levels were 6/6 (100%) underexpressed in OSCC, while it was underexpressed in 5/6 (83%) of OPMD. The mean value of PDCD4 was significantly downregulated in OPMD and OSCC than in healthy (p<0.05). The Spearman rank test obtained a p-value for the 2 tail test of 0.024 (p < 0.05), which showed a significant correlation between both, while the correlation coefficient of -0.530 showed a strong negative correlation of PDCD4 downregülation and OPMD, OSCC.
Conclusion: PDCD4 expression level is correlated with OSCC and OPMD. This study indicates that PDCD4 expression levels in liquid biopsies may have potential as a diagnostic biomarker in OSCC and OPMD.
AU  - MOLLAOGLU, NUR
AU  - Ersoy, Halil Erhan
AU  - Acik, Leyla
AU  - Korkmaz, Mehmet Hakan
AU  - Gultekin, Sibel Elif
AU  - Bozdağ, Leyla
AU  - Bayır, Ömer
DO  - 10.54617/adoklinikbilimler.1091916
PY  - 2022
JO  - ADO Klinik Bilimler Dergisi (online)
VL  - 11
IS  - 2
SN  - 1307-3540
SP  - 150
EP  - 156
DB  - TRDizin
UR  - http://search/yayin/detay/520753
ER  -