TY  - JOUR
TI  - Expression Levels of LINC01296 and LINC00152 in Breast
Cancer Tissue: Association with the Use of Oral Contraceptives
AB  - Objectives: Breast cancer is among the most commonly diagnosed cancers and one of the main causes of cancerrelated
deaths in females. Long noncoding RNAs (lncRNA) are vital regulators of both oncogenesis and tumor suppression
involved in crucial cancer pathways. Recent studies have demonstrated that LINC01296 and LINC00152 were
aberrantly upregulated in different tumor types. In this study, we aimed to assess the expression levels of LINC01296
and LINC00152 in breast cancer and its adjacent tissues.
Methods: Sample tissues were collected from 49 women with breast cancer referred to Shahid Faghihi Hospital in
Shiraz for surgery from 2017 to 2018. Total RNA was extracted from fresh tumor and normal breast cancer tissues and
expression of lncRNAs was assessed using real-time polymerase chain reaction.
Results: A significant upregulation of LINC01296 and LINC00152 in breast cancer tissues compared with the adjacent
normal tissues was observed (p<0.01). The Mann–Whitney analysis showed a significant relationship between the upregulation
of LINC01296 and the use of oral contraceptives in luminal B breast cancer subjects (p=0.028). No significant
relationship was found between the expression of LINC01296 and quantitative variables.
Conclusion: This study showed an upregulation of LINC01296 and LINC00152 in breast cancer tissues compared with
the adjacent normal tissues.
AU  - TABEİ, Seyed Mohammadbagher
AU  - KHANI, Pouria
AU  - FARAHANİ, Mostafa Davoodabadi
AU  - MAZLOOMREZAI, Mohsen
AU  - Neamatzadeh, Hossein
AU  - BARAHMAN, Maedeh
AU  - ILBEIGI, Shahrzad
AU  - DASTGHELB, Seyed Alireza
AU  - MANSOORİ, Yaser
DO  - 10.14744/ejmo.2022.33174
PY  - 2022
JO  - Eurasian Journal of Medicine and Oncology
VL  - 6
IS  - 1
SN  - 2587-2400
SP  - 83
EP  - 88
DB  - TRDizin
UR  - http://search/yayin/detay/521048
ER  -