TY  - JOUR
TI  - Circulating sTWEAK and its scavenger receptor sCD163
concentrations in patients with Behçet’s disease
AB  - Objectives: Behçet’s disease (BD) is a chronic multisystemic inflammatory disorder and is associated with many inflammatory
processes. The present study aimed to examine the serum levels of proinflammatory cytokine soluble tumor necrosis
factor-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor soluble cluster of differentiation 163 (sCD163)
simultaneously in patients with BD by considering their relationships with disease activity.
Methods: The study group included 53 patients with BD (29 females and 24 males) and 30 healthy individuals. Patients
with a lesion or active organ involvement were defined as active (n=39) and those without were identified as inactive
(n=14). Serum sTWEAK and sCD163 concentrations were determined by enzyme-linked immunosorbent assay.
Results: Serum sTWEAK and sCD163 levels were significantly increased in patients with BD compared with the healthy
group (p=0.016 and p=0.003, respectively). Concentrations of these two molecules were also higher in active and inactive
BD than the healthy individuals (p=0.043 for sTWEAK and p=0.010 for sCD163). Receiver operating characteristic
curve analysis revealed that serum sCD163 and sTWEAK levels had a discriminating ability between patients with BD
and healthy controls with area under the curve values of 0.706 and 0.661, respectively.
Conclusion: It was concluded that circulating sTWEAK and its scavenger receptor sCD163 levels were increased in BD,
significantly predicted the disease, and might be significant molecules to assess inflammation.
AU  - akcan, buket
AU  - Aksan, Burak
AU  - Orem, Asım
AU  - VANİZOR KURAL, Birgül
AU  - BAHADIR, Sevgi
AU  - aksu arıca, deniz
AU  - BALABAN YUCESAN, Fulya
AU  - OZER YAMAN, SERAP
DO  - 10.14744/ijmb.2022.98700
PY  - 2022
JO  - International Journal of Medical Biochemistry
VL  - 5
IS  - 2
SN  - 2587-2362
SP  - 89
EP  - 95
DB  - TRDizin
UR  - http://search/yayin/detay/521085
ER  -