Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
Yıl: 2021 Cilt: 13 Sayı: 4 Sayfa Aralığı: 375 - 383 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2020.2021.0305 İndeks Tarihi: 18-06-2022
Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
Öz: Objective: Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. BPA is also fat soluble and will
therefore contaminate breast milk. The European Food Safety Authority has set a limit for temporary tolerable daily intake of 4 µg/kg
body weight/day in breastfeeding infants. The aim of this study was to measure human milk BPA concentrations in Turkish women and
thus exclusively breastfed infants’ exposure to BPA.
Methods: Healthy, postnatal, exclusively breastfeeding women were recruited and breast milk samples were collected. Free BPA
concentration was analyzed in the milk samples using competitive enzyme-linked immunosorbent assay. Participants’ demographic
characteristics and nutritional habits were investigated through face-to-face interviews using a detailed questionnaire.
Results: Eighty women participated. Median milk free BPA level was 0.63 µg/L. There was no statistically significant association between
maternal body mass index, birth type, parity, infant birth week, infant birth weight, and human milk BPA concentration. Nevertheless,
there was a significant association between human milk BPA level and consumption of fast-food and carbonated drinks (p=0.022 and
p=0.018, respectively). Exclusively breastfed infants’ mean BPA exposure was 0.0099±0.0079 µg/kg bw/day. There was a moderate
negative significant correlation between infant BPA exposure and infant current body weight (r=0.327, p=0.003).
Conclusion: BPA exposure in exclusively breastfed infants was within accepted limits and the current dietary exposure level of infants
in this cohort was safe.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Farrugia F, Aquilina A, Vassallo J, Pace NP. Bisphenol A and type 2 diabetes mellitus: a review of epidemiologic, functional, and early life factors. Int J Environ Res Public Health 2021;18:716.
- 2. Konieczna A, Rutkowska A, Rachon D. Health risk of exposure to bisphenol A (BPA). Rocz Panstw Zakl Hig 2015;66:5-11.
- 3. Valentino R, D’Esposito V, Ariemma F, Cimmino I, Beguinot F, Formisano P. Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population? J Endocrinol Invest 2016;39:259- 263. Epub 2015 Jun 24
- 4. Yalcin EB, Kulkarni SR, Slitt AL, King R. Bisphenol A sulfonation is impaired in metabolic and liver disease. Toxicol Appl Pharmacol 2016;292:75-84. Epub 2015 Dec 19
- 5. Mercogliano R, Santonicola S. Investigation on bisphenol A levels in human milk and dairy supply chain: A review. Food Chem Toxicol 2018;114:98-107. Epub 2018 Feb 12
- 6. Dualde P, Pardo O, Corpas-Burgos F, Kuligowski J, Gormaz M, Vento M, Pastor A, Yusà V. Biomonitoring of bisphenols A, F, S in human milk and probabilistic risk assessment for breastfed infants. Sci Total Environ 2019;668:797-805. Epub 2019 Mar 3
- 7. Beausoleil C, Emond C, Cravedi JP, Antignac JP, Applanat M, Appenzeller BR, Beaudouin R, Belzunces LP, Canivenc-Lavier MC, Chevalier N, Chevrier C, Elefant E, Eustache F, Habert R, Kolf-Clauw M, Le Magueresse-Battistoni B, Mhaouty-Kodja S, Minier C, Multigner L, Schroeder H, Thonneau P, Viguié C, Pouzaud F, Ormsby JN, Rousselle C, Verines-Jouin L, Pasquier E, Michel C. Regulatory identification of BPA as an endocrine disruptor: Context and methodology. Mol Cell Endocrinol 2018;475:4-9. Epub 2018 Feb 6
- 8. Zimmers SM, Browne EP, O’Keefe PW, Anderton DL, Kramer L, Reckhow DA, Arcaro KF. Determination of free bisphenol A (BPA) concentrations in breast milk of U.S. women using a sensitive LC/MS/ MS method. Chemosphere 2014;104:237-243. Epub 2014 Feb 4
- 9. Ariemma F, D’Esposito V, Liguoro D, Oriente F, Cabaro S, Liotti A, Cimmino I, Longo M, Beguinot F, Formisano P, Valentino R. Low-dose bisphenol-a ımpairs adipogenesis and generates dysfunctional 3T3-L1 adipocytes. PLoS One 2016;11:e0150762.
- 10. Vaiserman A. Early-life Exposure to Endocrine Disrupting Chemicals and Later-life Health Outcomes: An Epigenetic Bridge? Aging Dis 2014;5:419-429.
- 11. Berge TLL, Lygre GB, Lie SA, Lindh CH, Björkman L. Bisphenol A in human saliva and urine before and after treatment with dental polymer-based restorative materials. Eur J Oral Sci 2019;127:435-444. Epub 2019 Aug 8
- 12. EFSA. CEF Panel (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. EFSA Journal 2015;13:23.
- 13. WHO (World Health Organization). Guideline: protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services. Geneva, World Health Organization, 2017.
- 14. Miliku K, Duan QL, Moraes TJ, Becker AB, Mandhane PJ, Turvey SE, Lefebvre DL, Sears MR, Subbarao P, Field CJ, Azad MB. Human milk fatty acid composition is associated with dietary, genetic, sociodemographic, and environmental factors in the CHILD Cohort Study. Am J Clin Nutr 2019;110:1370-1383.
- 15. Motas Guzmàn M, Clementini C, Pérez-Cárceles MD, Jiménez Rejón S, Cascone A, Martellini T, Guerranti C, Cincinelli A. Perfluorinated carboxylic acids in human breast milk from Spain and estimation of infant’s daily intake. Sci Total Environ 2016;544:595-600. Epub 2015 Dec 9
- 16. Chen J, Saili KS, Liu Y, Li L, Zhao Y, Jia Y, Bai C, Tanguay RL, Dong Q, Huang C. Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish. Chemosphere 2017;169:262-270. Epub 2016 Nov 20
- 17. Moustafa GG, Ahmed AAM. Impact of prenatal and postnatal exposure to bisphenol A on female rats in a two generational study: Genotoxic and immunohistochemical implications. Toxicol Rep 2016;3:685-695.
- 18. Garrow JS, Webster J. Quetelet’s index (W/H2) as a measure of fatness. Int J of Obes 1985;9:147-153.
- 19. Human Total Bisphenol A (BPA) ELISA Kit. Available from: https://cdn. mybiosource.com/tds/protocol_manuals/000000-799999/MBS109499. pdf
- 20. Kent JC, Prime DK, Garbin CP. Principles for Maintaining or Increasing Breast Milk Production. J Obstet Gynecol 2012;41:114-121. Epub 2011 Dec 12
- 21. Boix-Amorós A, Collado MC, Mira A. Relationship between milk microbiota, bacterial load, macronutrients, and human cells during lactation. Front Microbiol 2016;7:492.
- 22. United States Environmental Protection Agency. Guidance for Data Quality Assessment, Practical methods for Data Analysis. EPA QA/G9, QA96 Version. Report No. 600/R-96/084. 2000. Available from: https:// www.epa.gov/quality/guidance-data-quality-assessment
- 23. LaKind JS, Pollock T, Naiman DQ, Kim S, Nagasawa A, Clarke J. Factors affecting interpretation of national biomonitoring data from multiple countries: BPA as a case study. Environ Res 2019;173:318-329. Epub 2019 Mar 26
- 24. Sun Y, Irie M, Kishikawa N, Wada M, Kuroda N, Nakashima K. Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection. Biomed Chromatogr 2004;18:501-507.
- 25. Cao XL, Popovic S, Arbuckle TE, Fraser WD. Determination of free and total bisphenol A in human milk samples from Canadian women using a sensitive and selective GC-MS method. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2015;32:120-125. Epub 2014 Nov 24
- 26. Yi B, Kim C, Yang M. Biological monitoring of bisphenol A with HLPC/ FLD and LC/MS/MS assays. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878:2606-2610. Epub 2010 Feb 13
- 27. Nachman RM, Hartle JC, Lees PSJ, Groopman JD. Early life metabolism of bisphenol A: a systematic review of the literature. Curr Environ Health Rep 2014;1:90-100.
- 28. Tateoka Y. Bisphenol A concentration in breast milk following consumption of a canned coffee drink. J Hum Lact 2015;31:474-478. Epub 2014 Dec 17
- 29. LaKind JS, Lehmann GM, Davis MH, Hines EP, Marchitti SA, Alcala C, Lorber M. Infant dietary exposures to environmental chemicals and infant/child health: a critical assessment of the literature. Environ Health Perspect. 2018;126:96002. Erratum in: Environ Health Perspect. 2019;127:59001. Epub 2016 Mar 21
- 30. Street CM, Zhu Z, Finel M, Court MH. Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms. Xenobiotica 2017;47:1-10.
- 31. Sun F, Kang L, Xiang X, Li H, Luo X, Luo R, Lu C, Peng X. Recent advances and progress in the detection of bisphenol A. Anal Bioanal Chem 2016;408:6913-6927. Epub 2016 Aug 2
- 32. Azzouz A, Rascón AJ, Ballesteros E. Determination of free and conjugated forms of endocrine-disrupting chemicals in human biological fluids by GC-MS. Bioanalysis 2016;8:1145-1158. Epub 2016 May 24
- 33. Del Gobbo LC, Khatibzadeh S, Imamura F, Micha R, Shi P, Smith M, Myers SS, Mozaffarian D. Assessing global dietary habits: a comparison of national estimates from the FAO and the Global Dietary Database. Am J Clin Nutr 2015;101:1038-1046. Epub 2015 Mar 18
- 34. Casas M, Valvi D, Ballesteros-Gomez A, Gascon M, Fernández MF, Garcia-Esteban R, Iñiguez C, Martínez D, Murcia M, Monfort N, Luque N, Rubio S, Ventura R, Sunyer J, Vrijheid M. Exposure to Bisphenol A and Phthalates during Pregnancy and Ultrasound Measures of Fetal Growth in the INMA-Sabadell Cohort. Environ Health Perspect 2016;124:521-528. Epub 2015 Jul 21
- 35. Wagner CL, Baatz JE, Newton D, Hollis BW. Analytical considerations and general diagnostic and therapeutic ramifications of milk hormones during lactation. Best Pract Res Clin Endocrinol Metab 2018;32:5-16. Epub 2017 Nov 24
- 36. Kasper N, Peterson KE, Zhang Z, Ferguson KK, Sanchez BN, Cantoral A, Meeker JD, Tellez-Rojo MM, Pawlowski CM, Ettinger AS. Association of bisphenol A exposure with breastfeeding and perceived insufficient milk supply in Mexican women. Matern Child Health J 2016;20:1713- 1719. Erratum in: Matern Child Health J 2016;20:2411.
- 37. Martínez MA, Rovira J, Prasad Sharma R, Nadal M, Schuhmacher M, Kumar V. Comparing dietary and non-dietary source contribution of BPA and DEHP to prenatal exposure: a Catalonia (Spain) case study. Environ Res 2018;166:25-34. Epub 2018 May 31
- 38. Chen D, Kannan K, Tan H, Zheng Z, Feng YL, Wu Y, Widelka M. Bisphenol Analogues other than BPA: environmental occurrence, human exposure, and toxicity-a review. Environ Sci Technol 2016;50:5438-5453. Epub 2016 May 17
- 39. İnce T, Balcı A, Yalçın SS, Özkemahlı G, Erkekoglu P, Kocer-Gumusel B, Yurdakök K. Urinary bisphenol-A levels in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2018;31:829-836.
- 40. Zota AR, Phillips CA, Mitro SD. Recent fast food consumption and bisphenol a and phthalates exposures among the U.S. population in NHANES, 2003-2010. Environ Health Perspect 2016;124:1521-1528. Epub 2016 Apr 13
- 41. Almeida S, Raposo A, Almeida-González M, Carrascosa C. Bisphenol A: food exposure and impact on human health. Compr Rev Food Sci Food Saf 2018;17:1503-1517. Epub 2018 Sep 5
- 42. Cortina-Puig M, Hurtado-Fernandez E, Lacorte S. Plasticizers in drinking water and beverages. Curr Anal Chem 2018;14:344-357.
- 43. Honeycutt JA, Nguyen JQ, Kentner AC, Brenhouse HC. Effects of water bottle materials and filtration on bisphenol A content in laboratory animal drinking water. J Am Assoc Lab Anim Sci 2017;56:269-272.
- 44. Manoli E, Voutsa D. Food Containers and Packaging Materials as Possible Source of Hazardous Chemicals to Food. In: Takada H, Karapanagioti HK (eds). Hazardous Chemicals Associated with Plastics in the Marine. New York, Springer International Publishing, 2019;19- 50.
- 45. United States Food and Drug Administration. United States Food and Drug Administration. (2018) Bisphenol A (BPA): Use in Food Contact Application. Retrieved from the United States Food and Drug Administration. Vol 06/09/20192018. Available from: https://www. fda.gov/food/food-additives-petitions/bisphenol-bpa-use-food-contactapplication
- 46. Chailurkit L-O, Srijaruskul K, Ongphiphadhanakul B. Bisphenol A in canned carbonated drinks and plastic-bottled water from supermarkets. Expos Health 2017;9:243-248.
- 47. Kuruto-Niwa R, Tateoka Y, Usuki Y, Nozawa R. Measurement of bisphenol A concentrations in human colostrum. Chemosphere 2007;66:1160-1164. Epub 2006 Aug 14
- 48. Thompson FE, Kirkpatrick SI, Subar AF, Reedy J, Schap TE, Wilson MM, Krebs-Smith SM. The National Cancer Institute’s Dietary Assessment Primer: A Resource for Diet Research. J Acad Nutr Diet 2015;115:1986- 1995. Epub 2015 Oct 1
- 49. Hosseini S, Vázquez-Villegas P, Rito-Palomares M, Martinez-Chapa SO. Advantages, Disadvantages and Modifications of Conventional ELISA. Enzyme-linked Immunosorbent Assay (ELISA): From A to Z. Singapore, Springer, 2018;67-115.
- 50. Rowell C, Kuiper N, Preud’Homme H. Is container type the biggest predictor of trace element and BPA leaching from drinking water bottles? Food Chem 2016;202:88-93. Epub 2016 Jan 27
| APA | Çiftçi S, YALÇIN S, samur g (2021). Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. , 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| Chicago | Çiftçi Seda,YALÇIN Siddika Songül,samur gulhan Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. (2021): 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| MLA | Çiftçi Seda,YALÇIN Siddika Songül,samur gulhan Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. , 2021, ss.375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| AMA | Çiftçi S,YALÇIN S,samur g Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. . 2021; 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| Vancouver | Çiftçi S,YALÇIN S,samur g Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. . 2021; 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| IEEE | Çiftçi S,YALÇIN S,samur g "Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study." , ss.375 - 383, 2021. 10.4274/jcrpe.galenos.2020.2021.0305 |
| ISNAD | Çiftçi, Seda vd. "Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study". (2021), 375-383. https://doi.org/10.4274/jcrpe.galenos.2020.2021.0305 |
| APA | Çiftçi S, YALÇIN S, samur g (2021). Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. Journal of Clinical Research in Pediatric Endocrinology, 13(4), 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| Chicago | Çiftçi Seda,YALÇIN Siddika Songül,samur gulhan Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. Journal of Clinical Research in Pediatric Endocrinology 13, no.4 (2021): 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| MLA | Çiftçi Seda,YALÇIN Siddika Songül,samur gulhan Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. Journal of Clinical Research in Pediatric Endocrinology, vol.13, no.4, 2021, ss.375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| AMA | Çiftçi S,YALÇIN S,samur g Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. Journal of Clinical Research in Pediatric Endocrinology. 2021; 13(4): 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| Vancouver | Çiftçi S,YALÇIN S,samur g Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study. Journal of Clinical Research in Pediatric Endocrinology. 2021; 13(4): 375 - 383. 10.4274/jcrpe.galenos.2020.2021.0305 |
| IEEE | Çiftçi S,YALÇIN S,samur g "Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study." Journal of Clinical Research in Pediatric Endocrinology, 13, ss.375 - 383, 2021. 10.4274/jcrpe.galenos.2020.2021.0305 |
| ISNAD | Çiftçi, Seda vd. "Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study". Journal of Clinical Research in Pediatric Endocrinology 13/4 (2021), 375-383. https://doi.org/10.4274/jcrpe.galenos.2020.2021.0305 |
