Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
Yıl: 2021 Cilt: 13 Sayı: 4 Sayfa Aralığı: 391 - 399 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2020.2021.0230 İndeks Tarihi: 18-06-2022
Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?
Öz: Objective: Free hormones are biologically more active in target tissues. Thus, measurement of vitamin D taking into account
bioavailability and free vitamin D may be preferable, especially when evidence is contradictory, as in obese children. In order to assess
bioavailablity and free vitamin D, using a previously reported formula, vitamin D-binding protein (VDBP) level was measured and VDBP
polymorphisms were also evaluated because of variations in binding affinity.
Methods: Eighty-four obese and 78 healthy children were included. Anthropometry, calcium, phosphorus, alkaline-phosphatase,
parathyroid hormone (PTH), 25 hydroxyvitamin D [25(OH)D], bioavailable-free vitamin D, and VDBP concentration and polymorphism
were evaluated in the whole group.
Results: Obese girls had significantly higher PTH than normal weight girls (p=0.001). Regardless of gender, obese children had
significantly higher concentrations of VDBP (p=0.008) and PTH (p=0.002). When samples taken in winter were analyzed, PTH and
VDBP were found to be higher and bioavailable and free vitamin D lower in the obese group. There was no difference in terms of total
vitamin D between groups during the winter season.
Conclusion: While total, free, and bioavailable vitamin D in the obese group was similar to the control group in autumn, free and
bioavailable vitamin D in the winter was lower in the obese than the control group. In addition, PTH was higher in the obese group in
both autumn and winter. Therefore, more research is needed to evaluate the variability of free and bioavailable vitamin D according to
body habitus, season and the effect any differences may have.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Karacan Küçükali G, Gülbahar Ö, Özalkak Ş, DAGLI H, Ceylaner S, aycan z, SAVAS ERDEVE S (2021). Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. , 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| Chicago | Karacan Küçükali Gülin,Gülbahar Özlem,Özalkak Şervan,DAGLI HASAN,Ceylaner Serdar,aycan zehra,SAVAS ERDEVE SENAY Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. (2021): 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| MLA | Karacan Küçükali Gülin,Gülbahar Özlem,Özalkak Şervan,DAGLI HASAN,Ceylaner Serdar,aycan zehra,SAVAS ERDEVE SENAY Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. , 2021, ss.391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| AMA | Karacan Küçükali G,Gülbahar Ö,Özalkak Ş,DAGLI H,Ceylaner S,aycan z,SAVAS ERDEVE S Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. . 2021; 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| Vancouver | Karacan Küçükali G,Gülbahar Ö,Özalkak Ş,DAGLI H,Ceylaner S,aycan z,SAVAS ERDEVE S Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. . 2021; 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| IEEE | Karacan Küçükali G,Gülbahar Ö,Özalkak Ş,DAGLI H,Ceylaner S,aycan z,SAVAS ERDEVE S "Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?." , ss.391 - 399, 2021. 10.4274/jcrpe.galenos.2020.2021.0230 |
| ISNAD | Karacan Küçükali, Gülin vd. "Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?". (2021), 391-399. https://doi.org/10.4274/jcrpe.galenos.2020.2021.0230 |
| APA | Karacan Küçükali G, Gülbahar Ö, Özalkak Ş, DAGLI H, Ceylaner S, aycan z, SAVAS ERDEVE S (2021). Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. Journal of Clinical Research in Pediatric Endocrinology, 13(4), 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| Chicago | Karacan Küçükali Gülin,Gülbahar Özlem,Özalkak Şervan,DAGLI HASAN,Ceylaner Serdar,aycan zehra,SAVAS ERDEVE SENAY Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. Journal of Clinical Research in Pediatric Endocrinology 13, no.4 (2021): 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| MLA | Karacan Küçükali Gülin,Gülbahar Özlem,Özalkak Şervan,DAGLI HASAN,Ceylaner Serdar,aycan zehra,SAVAS ERDEVE SENAY Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. Journal of Clinical Research in Pediatric Endocrinology, vol.13, no.4, 2021, ss.391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| AMA | Karacan Küçükali G,Gülbahar Ö,Özalkak Ş,DAGLI H,Ceylaner S,aycan z,SAVAS ERDEVE S Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. Journal of Clinical Research in Pediatric Endocrinology. 2021; 13(4): 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| Vancouver | Karacan Küçükali G,Gülbahar Ö,Özalkak Ş,DAGLI H,Ceylaner S,aycan z,SAVAS ERDEVE S Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?. Journal of Clinical Research in Pediatric Endocrinology. 2021; 13(4): 391 - 399. 10.4274/jcrpe.galenos.2020.2021.0230 |
| IEEE | Karacan Küçükali G,Gülbahar Ö,Özalkak Ş,DAGLI H,Ceylaner S,aycan z,SAVAS ERDEVE S "Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?." Journal of Clinical Research in Pediatric Endocrinology, 13, ss.391 - 399, 2021. 10.4274/jcrpe.galenos.2020.2021.0230 |
| ISNAD | Karacan Küçükali, Gülin vd. "Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?". Journal of Clinical Research in Pediatric Endocrinology 13/4 (2021), 391-399. https://doi.org/10.4274/jcrpe.galenos.2020.2021.0230 |
