TY  - JOUR
TI  - Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia:
A Multicenter Study
AB  - Objective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate
intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D
deficiency in LNH in Turkey and to describe the characteristics of affected newborns.
Methods: Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December
2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry
System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase,
intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels.
Results: The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median
(range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence
of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants
and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels,
iPTH levels were low or inappropriately normal in 54.2% of the patients.
Conclusion: Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during
pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.
AU  - Hanta, Deniz
AU  - Terek, Demet
AU  - demir, nihat
AU  - kılıçbay, fatih
AU  - GÜNLEMEZ, AYLA
AU  - Özdemir, Özmert M.A.
AU  - ZENCIROGLU, AYSEGÜL
AU  - Guran, Omer
AU  - AKTÜRK ACAR, FİLİZ
AU  - aslan, yakup
AU  - Seymen, Gulcan
AU  - Celik, muhittin
AU  - Hatun, Sukru
AU  - çelik, kıymet
AU  - Kanmaz Kutman, H. Gozde
AU  - Mutlu, Mehmet
AU  - Uslu, Sinan
AU  - erol, sara
AU  - KARADENİZ, Leyla
AU  - ER, İlkay
AU  - Arısoy, Ayşe Engin
AU  - Sarici, Dilek
AU  - Tunç, Gaffari
AU  - Gökalp, Ayşe Sevim
AU  - TURAN, Ozden
AU  - Ertuğrul, Sabahattin
AU  - CELIK, HASAN TOLGA
AU  - Okulu, Emel
AU  - Narter, Fatma
AU  - KADER, SEBNEM
DO  - 10.4274/jcrpe.galenos.2020.2021.0169
PY  - 2021
JO  - Journal of Clinical Research in Pediatric Endocrinology
VL  - 13
IS  - 4
SN  - 1308-5727
SP  - 384
EP  - 390
DB  - TRDizin
UR  - http://search/yayin/detay/521131
ER  -