TY  - JOUR
TI  - The Association Between Arg72Pro C>G Polymorphism in the
p53 Gene and the Risk of Obesity
AB  - Introduction: The role of genetic factors in obesity has long been recognized, but their involved specific genes remained unidentified.
The relationship between p53 gene single nucleotide polymorphisms and the risk of obesity has been investigated in recent years.
Therefore, this study aimed to investigate the association of p53 Arg72Pro C>G (rs1042522) polymorphism with the risk of obesity in
our study.
Methods: This study included 52 patients with obesity (26 were females and 26 were males) and 52 normal-weight healthy controls.
Genomic DNA isolation was performed from the blood samples of all participants. P53 Arg72Pro C>G (rs1042522) polymorphism was
detected by real-time quantitative polymerase chain reaction from genomic DNA samples.
Results: No significant associations were identified between Arg72Pro (rs1042522) P53 polymorphism and obesity risk. Glucose levels
are significantly different between the obese and control groups with the CC and CG genotypes, but without difference in the GG
homozygous genotype.
Conclusion: Our study is one of the first to investigate the relationship between p53 codon 72 polymorphisms and obesity risk but
revealed no correlation between them. The relatively small number of participants may limit our study. Further research is needed
in a large cohort to associate the p53 gene Arg72Pro C>G (rs1042522) variant with obesity risk.
AU  - Kaya, Zehra
AU  - SOYOCAK, Ahu
AU  - Alis, Halil
AU  - Koc, Gulsah
DO  - 10.4274/imj.galenos.2022.64624
PY  - 2022
JO  - İstanbul Medical Journal
VL  - 23
IS  - 1
SN  - 2619-9793
SP  - 55
EP  - 59
DB  - TRDizin
UR  - http://search/yayin/detay/521217
ER  -