TY  - JOUR
TI  - Risk Factors and Prognostic Predictors of VentilatorAssociated Pneumonia in a Tertiary Care Hospita
AB  - Introduction: It was aimed to evaluate the risk factors for the development of ventilator-associated pneumonia (VAP) and clinical 
outcomes and prognostic predictors of VAP.
Materials and Methods: This retrospective and single-center study included patients aged ≥18 years who were diagnosed with VAP 
in the ICU. Patients were divided into two groups with VAP or without VAP. Univariable and multivariable analyses were used to assess 
risk factors and prognostic predictors of VAP.
Results: A total of 177 patients were evaluated. Mean length of intensive care unit (ICU) stay and the duration of mechanical ventilation was longer in patients with VAP than in patients without VAP [29 (3-107) vs. 12 (3-70) days, 22 (3-90) vs. 10 (3-45) days; p< 
0.001]. Rectal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKp) was found to be higher in the VAP group compared to the non-VAP group (n= 41, 58% vs. n= 25, 24%, p< 0.001). Ventilation period (OR= 1.07; 95% CI 1.02-1.12, p= 0.003), 
smoking (OR= 3.89; 95% CI 1.68-8.9, p= 0.001), and rectal colonization with CRKp (OR= 4.93; 95% CI 2.09-11.64, p< 0.001) 
were detected as independent risk factors for the development of VAP. Age (OR= 1.15; 95% CI 1.03-1.28, p= 0.01), SOFA score (OR= 
1.60; 95% CI 1.05-2.43, p= 0.02) and rectal colonization with CRKp (OR= 15.2; 95% CI 2.33-99.01, p= 0.004) were detected as 
independent risk factors for mortality in patients with VAP.
Conclusion: In conclusion, decreasing the patient-related and hospital environment related risk factors, routine screening of rectal colonizations with CRKp, and continuous practicing of the universal infection control measures may significantly decrease the prevalence 
of ventilator-associated pneumonia.
AU  - Oncul, Oral
AU  - ÇAGATAY, ARIF ATAHAN
AU  - basaran, seniha
AU  - Şimşek-Yavuz, Serap
AU  - orhun, günseli
AU  - Eraksoy, Haluk
AU  - OZSUT, HALIT
AU  - Çopur, Betül
DO  - 10.5578/flora.20229906
PY  - 2022
JO  - Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
VL  - 27
IS  - 1
SN  - 1300-932X
SP  - 55
EP  - 64
DB  - TRDizin
UR  - http://search/yayin/detay/521369
ER  -