Yıl: 2022 Cilt: 29 Sayı: 2 Sayfa Aralığı: 83 - 86 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2022.01.026 İndeks Tarihi: 19-06-2022

Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study

Öz:
Aim: To evaluate the hysteroscopy results performed before IVF treatment and its pathological findings that may affect pregnancy outcomes in patients undergoing the first IVF cycle. Materials and Methods: This descriptive study was carried out retrospectively at Gazi University Hospital and a private IVF Clinic between January 2016 and December 2021. A total of 458 patients who had hysteroscopy procedures prior to the planned IVF cycle were analyzed. Appropriate surgery was performed simultaneously during hysteroscopy in patients with uterine cavity abnormalities. Outcome measures were the frequency of uterine abnormalities detected during the hysteroscopy and confirmation of these abnormalities with their pathological findings. Results: Unexplained infertility was the most frequent infertility etiology among patients (50.9%). The most finding abnormality was endometrial polyp detected in 45.2% of patients during hysteroscopy. The second frequent abnormal finding was intrauterine adhesion, with a ratio of 15.9% of patients. The uterine cavity was seen as normal in 9.6% of patients during the hysteroscopy procedure. Endometrial sampling was performed in 75.5% of patients. The most common pathological result was endometrial polyp that was consistent with hysteroscopy findings (44.3%). Only 20.8% of patients had normal findings after pathological examination on the endometrial tissue samples. Conclusion: Evaluating the uterine cavity before the IVF cycle is necessary to reach successful outcomes. Undetected intrauterine lesions are frequently observed during hysteroscopy in asymptomatic patients previously examined by conventional methods. Hysteroscopy may be a reasonable approach to assess and restore the uterine cavity in patients undergoing the first IVF cycle.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, et al. Recurrent implantation failure: definition and management. Reprod Biomed Online. 2014;28(1):14-38.
  • 2. Lass A, Williams G, Abusheikha N, Brinsden P. The effect of endometrial polyps on outcomes of in vitro fertilization (IVF) cycles. J Assist Reprod Genet. 1999;16(8):410-5.
  • 3. Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod. 2006;21(12):3036-43.
  • 4. Moini A, Kiani K, Ghaffari F, Hosseini F. Hysteroscopic findings in patients with a history of two implantation failures following in vitro fertilization. Int J Fertil Steril. 2012;6(1):27-30.
  • 5. Cenksoy P, Ficicioglu C, Yıldırım G, Yesiladali M. Hysteroscopic findings in women with recurrent IVF failures and the effect of correction of hysteroscopic findings on subsequent pregnancy rates. Arch Gynecol Obstet. 2013;287(2):357-60.
  • 6. Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsev D, Nagy ZP, Abdelmassih R. Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive. Fertil Steril. 2003;80(6):1371-5.
  • 7. Pundir J, El Toukhy T. Uterine cavity assessment prior to IVF. Women’s health (London, England). 2010;6(6):841-7; quiz 7-8.
  • 8. Crosignani PG, Rubin BL. Optimal use of infertility diagnostic tests and treatments. The ESHRE Capri Workshop Group. Hum Reprod. 2000;15(3):723-32.
  • 9. Bosteels J, Weyers S, Mathieu C, Mol BW, D’Hooghe T. The effectiveness of reproductive surgery in the treatment of female infertility: facts, views and vision. Facts Views Vis Obgyn. 2010;2(4):232-52.
  • 10. El-Toukhy T, Campo R, Khalaf Y, Tabanelli C, Gianaroli L, Gordts SS, et al. Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial. Lancet. 2016;387(10038):2614- 21.
  • 11. Smit JG, Kasius JC, Eijkemans MJC, Koks CAM, van Golde R, Nap AW, et al. Hysteroscopy before in-vitro fertilisation (inSIGHT): a multicentre, randomised controlled trial. Lancet. 2016;387(10038):2622-9.
  • 12. Bozdag G, Aksan G, Esinler I, Yarali H. What is the role of office hysteroscopy in women with failed IVF cycles? Reprod Biomed Online. 2008;17(3):410-5.
  • 13. Rama Raju GA, Shashi Kumari G, Krishna KM, Prakash GJ, Madan K. Assessment of uterine cavity by hysteroscopy in assisted reproduction programme and its influence on pregnancy outcome. Arch Gynecol Obstet. 2006;274(3):160-4.
  • 14. Shamma FN, Lee G, Gutmann JN, Lavy G. The role of office hysteroscopy in in vitro fertilization. Fertil Steril. 1992;58(6):1237-9.
  • 15. Doldi N, Persico P, Di Sebastiano F, Marsiglio E, De Santis L, Rabellotti E, et al. Pathologic findings in hysteroscopy before in vitro fertilizationembryo transfer (IVF-ET). Gynecol Endocrinol. 2005;21(4):235-7.
  • 16. Hinckley MD, Milki AA. 1000 office-based hysteroscopies prior to in vitro fertilization: feasibility and findings. Jsls. 2004;8(2):103-7.
  • 17. Fatemi HM, Kasius JC, Timmermans A, van Disseldorp J, Fauser BC, Devroey P, et al. Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization. Hum Reprod. 2010;25(8):1959-65.
  • 18. Kamath MS, Bosteels J, D’Hooghe TM, Seshadri S, Weyers S, Mol BWJ, et al. Screening hysteroscopy in subfertile women and women undergoing assisted reproduction. Cochrane Database Syst Rev. 2019;4(4):Cd012856.
  • 19. Pundir J, Pundir V, Omanwa K, Khalaf Y, El-Toukhy T. Hysteroscopy prior to the first IVF cycle: a systematic review and meta-analysis. Reprod Biomed Online. 2014;28(2):151-61.
  • 20. El-Toukhy T, Sunkara SK, Coomarasamy A, Grace J, Khalaf Y. Outpatient hysteroscopy and subsequent IVF cycle outcome: a systematic review and meta-analysis. Reprod Biomed Online. 2008;16(5):712-9.
APA Demirdag E, Kutlucan H, Safarova S, Guler I, CEVHER AKDULUM M, Bozkurt N, Erdem M, ERDEM A (2022). Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. , 83 - 86. 10.5455/annalsmedres.2022.01.026
Chicago Demirdag Erhan,Kutlucan Hazal,Safarova Sahila,Guler Ismail,CEVHER AKDULUM M. Funda,Bozkurt Nuray,Erdem Mehmet,ERDEM AHMET Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. (2022): 83 - 86. 10.5455/annalsmedres.2022.01.026
MLA Demirdag Erhan,Kutlucan Hazal,Safarova Sahila,Guler Ismail,CEVHER AKDULUM M. Funda,Bozkurt Nuray,Erdem Mehmet,ERDEM AHMET Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. , 2022, ss.83 - 86. 10.5455/annalsmedres.2022.01.026
AMA Demirdag E,Kutlucan H,Safarova S,Guler I,CEVHER AKDULUM M,Bozkurt N,Erdem M,ERDEM A Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. . 2022; 83 - 86. 10.5455/annalsmedres.2022.01.026
Vancouver Demirdag E,Kutlucan H,Safarova S,Guler I,CEVHER AKDULUM M,Bozkurt N,Erdem M,ERDEM A Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. . 2022; 83 - 86. 10.5455/annalsmedres.2022.01.026
IEEE Demirdag E,Kutlucan H,Safarova S,Guler I,CEVHER AKDULUM M,Bozkurt N,Erdem M,ERDEM A "Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study." , ss.83 - 86, 2022. 10.5455/annalsmedres.2022.01.026
ISNAD Demirdag, Erhan vd. "Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study". (2022), 83-86. https://doi.org/10.5455/annalsmedres.2022.01.026
APA Demirdag E, Kutlucan H, Safarova S, Guler I, CEVHER AKDULUM M, Bozkurt N, Erdem M, ERDEM A (2022). Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. Annals of Medical Research, 29(2), 83 - 86. 10.5455/annalsmedres.2022.01.026
Chicago Demirdag Erhan,Kutlucan Hazal,Safarova Sahila,Guler Ismail,CEVHER AKDULUM M. Funda,Bozkurt Nuray,Erdem Mehmet,ERDEM AHMET Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. Annals of Medical Research 29, no.2 (2022): 83 - 86. 10.5455/annalsmedres.2022.01.026
MLA Demirdag Erhan,Kutlucan Hazal,Safarova Sahila,Guler Ismail,CEVHER AKDULUM M. Funda,Bozkurt Nuray,Erdem Mehmet,ERDEM AHMET Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. Annals of Medical Research, vol.29, no.2, 2022, ss.83 - 86. 10.5455/annalsmedres.2022.01.026
AMA Demirdag E,Kutlucan H,Safarova S,Guler I,CEVHER AKDULUM M,Bozkurt N,Erdem M,ERDEM A Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. Annals of Medical Research. 2022; 29(2): 83 - 86. 10.5455/annalsmedres.2022.01.026
Vancouver Demirdag E,Kutlucan H,Safarova S,Guler I,CEVHER AKDULUM M,Bozkurt N,Erdem M,ERDEM A Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study. Annals of Medical Research. 2022; 29(2): 83 - 86. 10.5455/annalsmedres.2022.01.026
IEEE Demirdag E,Kutlucan H,Safarova S,Guler I,CEVHER AKDULUM M,Bozkurt N,Erdem M,ERDEM A "Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study." Annals of Medical Research, 29, ss.83 - 86, 2022. 10.5455/annalsmedres.2022.01.026
ISNAD Demirdag, Erhan vd. "Evaluation of pre-cycle hysteroscopy findings and its pathological results of 458 patients undergoing IVF: A retrospective cohort study". Annals of Medical Research 29/2 (2022), 83-86. https://doi.org/10.5455/annalsmedres.2022.01.026