TY  - JOUR
TI  - Gastroprotective Effects of Fraxin with 
Antioxidant Activity on the EthanolInduced Gastric Ulce
AB  - Objective: Here, we planned to evaluate whether fraxin performed a gastroprotective 
activity or not with its antioxidant properties on the ethanol-induced gastric ulcer.
Methods: Wistar Albino male rats were assigned to 4 groups with 6 animals in each group. 
The groups were arranged as control (group I), ethanol (group II), ethanol+omeprazole 
(group III), and ethanol+fraxin (group IV) groups. All subjects were sacrificed 3 hours after 
administration of 70%, 10 mg/kg of ethanol. In groups III and IV, rats were given omeprazole 
30 mg/kg and fraxin 50 mg/kg, respectively, by oral gavage 30 minutes before the ethanol 
induction. At the end of the experiment, the gastric tissues were removed, washed and the 
ulcer areas were macroscopically evaluated. Later, the samples were stored under appropriate conditions for biochemical analysis.
Results: Superoxide dismutase (SOD) and glutathione (GSH) levels decreased, and malondialdehyde (MDA) value increased in group II compared to group I (p<0.05). However, these 
results changed significantly in groups III and IV (p<0.05). In group III, a significant reduction 
was noticed in gastric ulcer areas compared to group II (p<0.05). In group IV, the size of the 
gastric ulcer areas decreased considerably compared to group II (p<0.05).
Conclusion: In the light of biochemical and macroscopic findings, fraxin showed a gastroprotective effect with its antioxidant activity against ethanol-induced gastric ulcers.
AU  - guler, mustafa can
AU  - tanyeli, ayhan
AU  - Ekinci Akdemir, Fazile Nur
AU  - Bayir, Yasin
AU  - Eraslan, Ersen
DO  - 10.14744/scie.2020.28291
PY  - 2022
JO  - Southern Clinics of Istanbul Eurasia
VL  - 33
IS  - 1
SN  - 2587-0998
SP  - 21
EP  - 26
DB  - TRDizin
UR  - http://search/yayin/detay/521428
ER  -