Yıl: 2022 Cilt: 29 Sayı: 2 Sayfa Aralığı: 164 - 168 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2021.08.521 İndeks Tarihi: 19-06-2022

Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery

Öz:
Aim: The present study aims to investigate the effect of high body mass index (BMI) on short-term outcomes and survival in patients following intra-abdominal malignancy surgery. Materials and Methods: The study was carried out in Ankara University, Department of Surgical Oncology. We retrospectively analyzed the data of patients who underwent gastrectomy and colectomy for malignancy in our clinic between August 2019 and August 2020. BMI was calculated by dividing body weight (kg) by height (m) squared. The patients were classified into two groups as normal (<25.0 kg/m2 ) and overweight (≥25 kg/m2 ) in terms of BMI. Results: 158 patients were included in our study. 78 (49.3%) had undergone surgery for gastric cancer and 80 (50.7%) for colorectal cancer. 73 (46.2%) patients were female and 85 (53.8%) male. The mean age was 61.50±13.37. Fifty four (34.2%) patients had BMI <25 kg/m2 and 104 (65.8%) of them were ≥25 kg/m2 . 57.6% of the patients operated on for gastric cancer and 75.6% for colorectal cancer had high BMI, and the difference between the two groups was statistically significant (p = 0.01). An investigation of relationship between BMI and mortality revealed that 37 with BMI ≥25kg/m2 and 5 with BMI <25kg/m2 died. The difference was statistically significant (p<0.001). Conclusion: BMI is an important factor affecting postoperative morbidity and mortality in patients with gastric and colorectal malignant tumors. In the present study, we show that overweight may be associated with severe postoperative complications and poor prognosis in these patients. We suggest that surgeons be highly aware of BMI to make effective treatment plans in gastric and colorectal cancer cases
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.
  • 2. Roukos DH, Kappas AM. Perspectives in the treatment of gastric cancer. Nat Clin Pract Oncol 2005;2:98-107.
  • 3. Siegel R. KD Miller & A. Jemal. 2018. Cancer statistics. CA Cancer J Clin 2018;68:7-30.
  • 4. Boyle T, Fritschi L, Tabatabaei SM, et al. Smoking, alcohol, diabetes, obesity, socioeconomic status, and the risk of colorectal cancer in a population- based case-control study. Cancer Causes Control 2014;25:1659-68.
  • 5. Dietz DW, Cancer CfOSToR. Multidisciplinary management of rectal cancer: the OSTRICH. J Gastrointest Surg 2013;17:1863-8.
  • 6. Wang K, Wang D, Pan L, et al. Prevalence of obesity and related factors among Bouyei and Han peoples in Guizhou Province, Southwest China. PloS one. 2015;10:e0129230.
  • 7. Larsson SC, Orsini N, Wolk A. Body mass index and pancreatic cancer risk: a meta-analysis of prospective studies. Int J Cancer 2007;120:1993- 8.
  • 8. Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. The Lancet 2008;371:569-78.
  • 9. Recalde M, Davila-Batista V, Díaz Y, et al. Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain. BMC Med 2021;19:1-14.
  • 10. Bae J-M. Body mass index and risk of gastric cancer in Asian adults: a meta-epidemiological meta-analysis of population-based cohort studies. Meta-Analysis Cancer Res Treat 2020;52:369.
  • 11. Madani NH, Etemadi A, Nalini M, et al. Obesity and incident gastrointestinal cancers: overall body size or central obesity measures, which factor matters? Eur J Cancer Prev 2021;30:267-74.
  • 12. Denost Q, Quintane L, Buscail E, Martenot M, Laurent C, Rullier E. Shortand long-term impact of body mass index on laparoscopic rectal cancer surgery. Int J Colorectal Dis 2013;15:463-9.
  • 13. Kunisaki C, Makino H, Takagawa R, et al. Predictive factors for surgical complications of laparoscopy- assisted distal gastrectomy for gastric cancer. Surg Endosc 2009;23:2085-93.
  • 14. House MG, Fong Y, Arnaoutakis DJ, et al. Preoperative predictors for complications after pancreaticoduodenectomy: impact of BMI and body fat distribution. J Gastrointest Surg 2008;12:270-8.
  • 15. Chern H, Chou J, Donkor C, et al. Effects of obesity in rectal cancer surgery. J Am Coll Surg 2010;211:55-60.
  • 16. Yamashita M, Tominaga T, Nonaka T, et al. Impact of obesity on shortterm outcomes of laparoscopic colorectal surgery for Japanese patients with colorectal cancer: A multicenter study. Multicenter Study Asian J Endosc Surg 2021;14:432-42.
  • 17. Tsujinaka T, Sasako M, Yamamoto S, et al. Influence of overweight on surgical complications for gastric cancer: results from a randomized control trial comparing D2 and extended para-aortic D3 lymphadenectomy (JCOG9501). Ann Surg Oncol 2007;14:355-61.
  • 18. Sun Y, Chi P. Impact of body mass index on surgical and oncological outcomes in laparoscopic total mesorectal excision for locally advanced rectal cancer after neoadjuvant 5-fluorouracil-based chemoradiotherapy. Gastroenterol Res Pract 2017;2017:1509140.
  • 19. Zhang X, Wu Q, Gu C, et al. The effect of increased body mass indexvalues on surgical outcomes after radical resection for low rectal cancer. Surg Today 2019;49:401-9.
  • 20. Dhar DK, Kubota H, Tachibana M, et al. Body mass index determines the success of lymph node dissection and predicts the outcome of gastric carcinoma patients. Oncology 2000;59:18-23.
  • 21. Doleman B, Mills K, Lim S, et al. Body mass index and colorectal cancer prognosis: a systematic review and meta-analysis. Tech Coloproctol 2016;20:517-35.
  • 22. Kodera Y, Ito S, Yamamura Y, et al. Obesity and outcome of distal gastrectomy with D2 lymphadenectomy for carcinoma. Hepatogastroenterology 2004;51:1225-8.
  • 23. Kwak HD, Ju JK, Kang DW, et al. Outcomes according to body mass index following laparoscopic surgery in patients with colorectal cancer. J Minim Access Surg 2018;14:134.
  • 24. Bickenbach KA, Denton B, Gonen M, et al. Impact of obesity on perioperative complications and long-term survival of patients with gastric cancer. Ann Surg Oncol 2013;20:780-7.
  • 25. Kuritzkes BA, Pappou EP, Kiran RP, et al. Visceral fat area, not body mass index, predicts postoperative 30- day morbidity in patients undergoing colon resection for cancer. Int J Colorectal Dis 2018;33:1019-28.
  • 26. Ejaz A, Spolverato G, Kim Y, et al. Impact of body mass index on perioperative outcomes and survival after resection for gastric cancer. Multicenter Study J Surg Res 2015;195:74-82.
  • 27. Kim EY, Jun KH, Kim SY, et al. Body mass index and skeletal muscle index are useful prognostic factors for overall survival after gastrectomy for gastric cancer: Retrospective cohort study. Medicine (Baltimore) 2020;99:e23363.
  • 28. Hirao M, Tsujinaka T, Imamura H, et al. Overweight is a risk factor for surgical site infection following distal gastrectomy for gastric cancer. Clinical Trial Gastric Cancer 2013;16:239-44.
  • 29. Struecker B, Biebl M, Dadras M, et al. The impact of obesity on outcomes following resection for gastric cancer. Dig Surg 2017;34:133-41.
  • 30. Wong J, Rahman S, Saeed N, et al. Effect of body mass index in patients undergoing resection for gastric cancer: a single center US experience. J Gastrointest Surgy 2014;18:505-11.
  • 31. Zhao W, Wang P, Sun W, et al. Effects of a high body mass index on the short-term outcomes and prognosis after radical gastrectomy. Surg Today 2021:1-10.
  • 32. Kulig J, Sierzega M, Kolodziejczyk P, et al. Implications of overweight in gastric cancer: a multicenter study in a Western patient population. Eur J Surg Oncol (EJSO). 2010;36:969-76.
  • 33. Kim MG, Yook JH, Kim KC, et al. Influence of obesity on early surgical outcomes of laparoscopic-assisted gastrectomy in gastric cancer. Comparative Study Surg Laparosc Endosc Percutan Tech 2011;21:151-4.
  • 34. Benoist S, Panis Y, Alves A, Valleur P. Impact of obesity on surgical outcomes after colorectal resection. Am J Surg 2000;179:275-81.
  • 35. Jeong SH, Kim P, Yi SW, et al. Body mass index and gastrointestinal cancer mortality in Korean adults: a prospective cohort study. J Gastroenterol Hepatol 2018;33:1582-9.
  • 36. Bell S, Kong J, Wale R, et al. The effect of increasing body mass index on laparoscopic surgery for colon and rectal cancer. Int J Colorectal Dis 2018;20:778- 88.
  • 37. Meyerhardt JA, Niedzwiecki D, Hollis D, et al. Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803. J Clin Oncol 2008;26:4109.
  • 38. Schlesinger S, Siegert S, Koch M, et al. Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta- analysis. Meta-Analysis Cancer Causes Contro 2014;25:1407- 18.
  • 39. Chen HN, Chen XZ, Zhang WH, et al. The impact of body mass index on the surgical outcomes of patients with gastric cancer: a 10-year, singleinstitution cohort study. Medicine (Baltimore) 2015;94:e1769.
APA Yüksel C, Gojayev A, Aydin F, Ünal A, Demirci S (2022). Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. , 164 - 168. 10.5455/annalsmedres.2021.08.521
Chicago Yüksel Cemil,Gojayev Afig,Aydin Ferit,Ünal Ali Ekrem,Demirci Salim Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. (2022): 164 - 168. 10.5455/annalsmedres.2021.08.521
MLA Yüksel Cemil,Gojayev Afig,Aydin Ferit,Ünal Ali Ekrem,Demirci Salim Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. , 2022, ss.164 - 168. 10.5455/annalsmedres.2021.08.521
AMA Yüksel C,Gojayev A,Aydin F,Ünal A,Demirci S Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. . 2022; 164 - 168. 10.5455/annalsmedres.2021.08.521
Vancouver Yüksel C,Gojayev A,Aydin F,Ünal A,Demirci S Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. . 2022; 164 - 168. 10.5455/annalsmedres.2021.08.521
IEEE Yüksel C,Gojayev A,Aydin F,Ünal A,Demirci S "Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery." , ss.164 - 168, 2022. 10.5455/annalsmedres.2021.08.521
ISNAD Yüksel, Cemil vd. "Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery". (2022), 164-168. https://doi.org/10.5455/annalsmedres.2021.08.521
APA Yüksel C, Gojayev A, Aydin F, Ünal A, Demirci S (2022). Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. Annals of Medical Research, 29(2), 164 - 168. 10.5455/annalsmedres.2021.08.521
Chicago Yüksel Cemil,Gojayev Afig,Aydin Ferit,Ünal Ali Ekrem,Demirci Salim Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. Annals of Medical Research 29, no.2 (2022): 164 - 168. 10.5455/annalsmedres.2021.08.521
MLA Yüksel Cemil,Gojayev Afig,Aydin Ferit,Ünal Ali Ekrem,Demirci Salim Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. Annals of Medical Research, vol.29, no.2, 2022, ss.164 - 168. 10.5455/annalsmedres.2021.08.521
AMA Yüksel C,Gojayev A,Aydin F,Ünal A,Demirci S Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. Annals of Medical Research. 2022; 29(2): 164 - 168. 10.5455/annalsmedres.2021.08.521
Vancouver Yüksel C,Gojayev A,Aydin F,Ünal A,Demirci S Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery. Annals of Medical Research. 2022; 29(2): 164 - 168. 10.5455/annalsmedres.2021.08.521
IEEE Yüksel C,Gojayev A,Aydin F,Ünal A,Demirci S "Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery." Annals of Medical Research, 29, ss.164 - 168, 2022. 10.5455/annalsmedres.2021.08.521
ISNAD Yüksel, Cemil vd. "Impact of body mass index on short-term outcomes following gastric and colorectral cancer surgery". Annals of Medical Research 29/2 (2022), 164-168. https://doi.org/10.5455/annalsmedres.2021.08.521