TY  - JOUR
TI  - Comparison of the Effectiveness of Rapamycin and
Gabapentin Treatment in Rats with Induced Sciatic
Nerve Injury
AB  - Objective: The purpose of this study was to compare the therapeutic effects of gabapentin (GBP) and different doses of
rapamycin (RAPA) in an induced sciatic nerve (SN)-injury rat model.
Materials and Methods: The study consisted of 7 groups: Control, Sham, High-dose rapamycin (RAPA-H), Low-dose rapamycin (RAPA-L), GBP, DMSO and DMSO+nerve injury (DMSO+NI). Medical treatment was administered intraperitoneally
for 30 days after the induction of SN injury.
Results: Significant differences (p<0.001 for all) were found in comparisons between the groups in terms of axon diameter,
axon number, and neurofilament (NF) and S100 immunointensity. Among the treatment groups, the highest mean axon
diameter value, close to that of the Control group, was seen in the RAPA-L group. In terms of axon number, the value closest
to that of the Control group was measured in the GBP group. The NF and S100 immunodensity in the RAPA-L group was
similar to that of the GBP group. The S100 immunodensity in the RAPA-L group was closest to that of the Control group.
The highest conduction velocity and distal latency values were recorded in the RAPA-L group.
Conclusion: The histological and electrophysiological findings observed in this study suggest that RAPA-L treatment is a
promising alternative to GBP.
AU  - Çolpak, Halis Ali
AU  - Ertürk Zararsız, Gözde
AU  - Yay, Arzu Hanım
AU  - Kumandaş, Sefer
AU  - GÜNAY CANPOLAT, DILEK
AU  - Önder, Gözde Özge
AU  - Canpolat, Mehmet
AU  - Yetkin, Mehmet Fatih
DO  - 10.14744/etd.2021.87405
PY  - 2022
JO  - Erciyes Medical Journal
VL  - 44
IS  - 1
SN  - 2149-2247
SP  - 56
EP  - 62
DB  - TRDizin
UR  - http://search/yayin/detay/521937
ER  -