TY  - JOUR
TI  - Clinical Characteristics and Outcomes of COVID-19 in Turkish
Patients with Hematological Malignancies
AB  - Objective: Patients with solid malignancies are more vulnerable
to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
infection than the healthy population. The outcome of SARS-CoV-2
infection in highly immunosuppressed populations, such as in patients
with hematological malignancies, is a point of interest. We aimed to
analyze the symptoms, complications, intensive care unit admissions,
and mortality rates of patients with hematological malignancies
infected with SARS-CoV-2 in Turkey.
Materials and Methods: In this multicenter study, we included
340 adult and pediatric patients diagnosed with SARS-CoV-2 from
March to November 2020. Diagnosis and status of primary disease,
treatment schedules for hematological malignancies, time from last
treatment, life expectancy related to the hematological disease, and
comorbidities were recorded, together with data regarding symptoms,
treatment, and outcome of SARS-CoV-2 infection.
Results: Forty four patients were asymptomatic at diagnosis of SARSCoV-
2 infection. Among symptomatic patients, fever, cough, and
dyspnea were observed in 62.6%, 48.8%, and 41.8%, respectively. Sixtynine
(20%) patients had mild SARS-CoV-2 disease, whereas moderate,
severe, and critical disease was reported in 101 (29%), 71 (20%), and 55
(16%) patients, respectively. Of the entire cohort, 251 (73.8%) patients
were hospitalized for SARS-CoV-2. Mortality related to SARS-CoV-2
infection was 26.5% in the entire cohort; this comprised 4.4% of those
patients with mild disease, 12.4% of those with moderate disease,
and 83% of those with severe or critical disease. Active hematological
disease, lower life expectancy related to primary hematological disease,
neutropenia at diagnosis of SARS-CoV-2, ICU admission, and first-line
therapy used for coronavirus disease-2019 treatment were found to be
related to higher mortality rates. Treatments with hydroxychloroquine
alone or in combination with azithromycin were associated with a
higher rate of mortality in comparison to favipiravir use.
Conclusion: Patients with hematological malignancy infected with
SARS-CoV-2 have an increased risk of severe disease and mortality.
AU  - selim, cem
AU  - İNCE, İDRİS
AU  - balik aydin, berrin
AU  - Yavuz, Yasemin
AU  - Yuksel, Meltem Kurt
AU  - Gürman, Günhan
AU  - Ozkocaman, Vildan
AU  - ÇELİK, Serhat
AU  - Keklik, Muzaffer
AU  - Guven, Zeynep Tugba
AU  - OZKURT, ZÜBEYDE NUR
AU  - Toprak, Selami Kocak
AU  - Aksu, Tekin
AU  - Diz-Kucukkaya, Reyhan
AU  - Yonal-Hindilerden, Ipek
AU  - Ceneli, Ozcan
AU  - Çiftçiler, Rafiye
AU  - Demirci, Ufuk
AU  - SADRİ, Soğol
AU  - ABBASOV, HAMZA
AU  - Sadri, Sevil
AU  - Ar, Muhlis Cem
AU  - Doğan, Ali
AU  - ATAS, Unal
AU  - GUNDUZ, Eren
AU  - Ozsan, Guner Hayri
AU  - Üsküdar Teke, Hava
AU  - Can, Ferda
AU  - YAĞCI, Münci
AU  - Unal, Sule
AU  - Hindilerden, Fehmi
AU  - Gursoy, Vildan
AU  - Beköz, Hüseyin Saffet
AU  - MARAL, SENEM
AU  - AKYAY, ARZU
AU  - Eroğlu küçükdiler, Ayşe hilal
AU  - YUCEL, ORHAN KEMAL
AU  - civriz bozdag, sinem
AU  - Terzi, Hatice
AU  - Andic, Neslıhan
AU  - Yilmaz, Umut
AU  - Özkalemkaş, Fahir
AU  - Yavuz, Boran
AU  - bas, volkan
AU  - ABİSHOV, Elgün
AU  - yavasoglu, İrfan
AU  - albayrak, canan
AU  - Güler, Nil
AU  - Demir, Ahmet Muzaffer
AU  - GOKSOY, HASAN
AU  - Demircioğlu, Sinan
AU  - Topcuoglu, Pervin
AU  - Ozcan, Muhit
AU  - Beksac, Meral
AU  - Cengiz Seval, Guldane
AU  - mutlu, Yaşa gül
AU  - AYDIN KAYNAR, LALE
AU  - yegin, zeynep arzu
AU  - Baydar, Mustafa
DO  - 10.4274/tjh.galenos.2021.2021.0287
PY  - 2022
JO  - Turkish Journal of Hematology
VL  - 39
IS  - 1
SN  - 1300-7777
SP  - 43
EP  - 54
DB  - TRDizin
UR  - http://search/yayin/detay/522061
ER  -