Association of Pre-Transplant Angiopoietin-2 Index with the Risk
of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell
Transplantation

SATIRER, Özlem; Alkan Mumcu, Berna; OKUR, FATMA VISAL; ÇETİNKAYA, Duygu; CEVHER ZEYTIN, inci; Karakaya, Jale

doi:10.4274/tjh.galenos.2021.2021.0434

Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation

Özlem SATIRER, (Hacettepe Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Ankara, Türkiye)

İnci Cevher ZEYTİN, (Hacettepe Üniversitesi, Kök Hücre Araştırma ve Geliştirme Merkezi (PEDI-STEM), Ankara, Türkiye)

Berna ALKAN, (Hacettepe Üniversitesi, Kök Hücre Araştırma ve Geliştirme Merkezi (PEDI-STEM), Ankara, Türkiye)

Jale KARAKAYA, (Hacettepe Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Ankara, Türkiye)

Duygu ÇETİNKAYA, (Hacettepe Üniversitesi, Kök Hücre Araştırma ve Geliştirme Merkezi (PEDI-STEM), Ankara, Türkiye)

Fatma VİSAL OKUR (Hacettepe Üniversitesi, Kök Hücre Araştırma ve Geliştirme Merkezi (PEDI-STEM), Ankara, Türkiye)

Turkish Journal of Hematology

2 0

Yıl: 2022 Cilt: 39 Sayı: 1 Sayfa Aralığı: 61 - 65 Metin Dili: İngilizce DOI: 10.4274/tjh.galenos.2021.2021.0434 İndeks Tarihi: 21-06-2022

Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation

Öz:

Objective: Angiogenic factors (AFs) released under endothelial stress are reflective of tissue healing, while some may also contribute to tissue damage/inflammation. We investigated whether alterations in the pre-transplant levels of AFs were associated with the risk of acute graft-versus-host disease (aGvHD). Materials and Methods: The pre-conditioning plasma levels of angiopoietin-2 (Ang2), endoglin, and follistatin were measured for 37 patients together with inflammatory markers. The index values defined were evaluated to better identify the alterations. Results: The patients had higher pre-conditioning levels of Ang2, endoglin, and follistatin compared to controls. The patients with aGvHD had higher Ang2 index and lower albumin index scores in comparison to those without aGvHD. Multivariate analysis revealed that the pre-transplant Ang2 index was an independent risk factor for aGvHD development. Conclusion: Pre-transplant evaluation of plasma Ang2 levels along with inflammatory status even before conditioning is associated with endothelial vulnerability. The pre-transplant Ang2 index could be a promising candidate to estimate the risk of aGvHD.

Anahtar Kelime:

Pre-transplant Anjiyopoietin-2 İndeksinin Hematopoietik Kök Hücre Transplantasyonu Sonrası Akut Graft Versus Host Hastalığı Riski ile İlişkisi

Öz:

Amaç: Endotelyal stres altında salınan anjiyojenik faktörler (AF), doku iyileşmesini yansıtırken, bazıları doku hasarına/iltihabına katkıda bulunabilir. Bu çalışmamızda pre-transplant AF düzeylerindeki değişikliklerin akut graft versus host hastalığı (aGvHH) riski ile ilişkili olup olmadığını araştırdık. Gereç ve Yöntemler: Otuz yedi hastada plazma anjiyopoietin-2, endoglin ve follistatin seviyeleri, enflamatuvar belirteçlerle birlikte hazırlama rejimi öncesi değerlendirildi. Tanımlanan indeks değerleri AF düzeylerindeki değişiklikleri daha iyi tespit edebilmek için kullanıldı. Bulgular: Kontrollere kıyasla hastaların nakil öncesi bakılan Ang2, endoglin ve follistatin seviyeleri daha yüksekti. aGvHH gelişen hastalarda, gelişmeyenlere kıyasla daha yüksek Ang2 indeks ve daha düşük albümin indeks değerleri saptandı. Çok değişkenli analizler, pre-transplant Ang2 indeksinin aGvHH gelişimi için bağımsız bir risk faktörü olduğunu ortaya koydu. Sonuç: Plazma Ang2 düzeylerinin nakil öncesi hatta hazırlama rejimi verilmeden önce enflamatuvar durum ile birlikte değerlendirilmesi endotelin hasara yatkınlığı hakkında bilgi verebilir. Pre-transplant Ang2 indeksi, aGvHH riskini tahmin etmek için kullanabilecek bir belirteç olabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

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APA	SATIRER Ö, CEVHER ZEYTIN i, Alkan Mumcu B, Karakaya J, ÇETİNKAYA D, OKUR F (2022). Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. , 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
Chicago	SATIRER Özlem,CEVHER ZEYTIN inci,Alkan Mumcu Berna,Karakaya Jale,ÇETİNKAYA Duygu,OKUR FATMA VISAL Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. (2022): 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
MLA	SATIRER Özlem,CEVHER ZEYTIN inci,Alkan Mumcu Berna,Karakaya Jale,ÇETİNKAYA Duygu,OKUR FATMA VISAL Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. , 2022, ss.61 - 65. 10.4274/tjh.galenos.2021.2021.0434
AMA	SATIRER Ö,CEVHER ZEYTIN i,Alkan Mumcu B,Karakaya J,ÇETİNKAYA D,OKUR F Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. . 2022; 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
Vancouver	SATIRER Ö,CEVHER ZEYTIN i,Alkan Mumcu B,Karakaya J,ÇETİNKAYA D,OKUR F Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. . 2022; 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
IEEE	SATIRER Ö,CEVHER ZEYTIN i,Alkan Mumcu B,Karakaya J,ÇETİNKAYA D,OKUR F "Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation." , ss.61 - 65, 2022. 10.4274/tjh.galenos.2021.2021.0434
ISNAD	SATIRER, Özlem vd. "Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation". (2022), 61-65. https://doi.org/10.4274/tjh.galenos.2021.2021.0434

APA	SATIRER Ö, CEVHER ZEYTIN i, Alkan Mumcu B, Karakaya J, ÇETİNKAYA D, OKUR F (2022). Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. Turkish Journal of Hematology, 39(1), 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
Chicago	SATIRER Özlem,CEVHER ZEYTIN inci,Alkan Mumcu Berna,Karakaya Jale,ÇETİNKAYA Duygu,OKUR FATMA VISAL Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. Turkish Journal of Hematology 39, no.1 (2022): 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
MLA	SATIRER Özlem,CEVHER ZEYTIN inci,Alkan Mumcu Berna,Karakaya Jale,ÇETİNKAYA Duygu,OKUR FATMA VISAL Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. Turkish Journal of Hematology, vol.39, no.1, 2022, ss.61 - 65. 10.4274/tjh.galenos.2021.2021.0434
AMA	SATIRER Ö,CEVHER ZEYTIN i,Alkan Mumcu B,Karakaya J,ÇETİNKAYA D,OKUR F Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. Turkish Journal of Hematology. 2022; 39(1): 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
Vancouver	SATIRER Ö,CEVHER ZEYTIN i,Alkan Mumcu B,Karakaya J,ÇETİNKAYA D,OKUR F Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation. Turkish Journal of Hematology. 2022; 39(1): 61 - 65. 10.4274/tjh.galenos.2021.2021.0434
IEEE	SATIRER Ö,CEVHER ZEYTIN i,Alkan Mumcu B,Karakaya J,ÇETİNKAYA D,OKUR F "Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation." Turkish Journal of Hematology, 39, ss.61 - 65, 2022. 10.4274/tjh.galenos.2021.2021.0434
ISNAD	SATIRER, Özlem vd. "Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation". Turkish Journal of Hematology 39/1 (2022), 61-65. https://doi.org/10.4274/tjh.galenos.2021.2021.0434