TY  - JOUR
TI  - Association of Pre-Transplant Angiopoietin-2 Index with the Risk
of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell
Transplantation
AB  - Objective: Angiogenic factors (AFs) released under endothelial stress
are reflective of tissue healing, while some may also contribute to
tissue damage/inflammation. We investigated whether alterations in
the pre-transplant levels of AFs were associated with the risk of acute
graft-versus-host disease (aGvHD).
Materials and Methods: The pre-conditioning plasma levels of
angiopoietin-2 (Ang2), endoglin, and follistatin were measured for
37 patients together with inflammatory markers. The index values
defined were evaluated to better identify the alterations.
Results: The patients had higher pre-conditioning levels of Ang2,
endoglin, and follistatin compared to controls. The patients with
aGvHD had higher Ang2 index and lower albumin index scores in
comparison to those without aGvHD. Multivariate analysis revealed
that the pre-transplant Ang2 index was an independent risk factor for
aGvHD development.
Conclusion: Pre-transplant evaluation of plasma Ang2 levels along
with inflammatory status even before conditioning is associated with
endothelial vulnerability. The pre-transplant Ang2 index could be a
promising candidate to estimate the risk of aGvHD.
AU  - SATIRER, Özlem
AU  - Alkan Mumcu, Berna
AU  - OKUR, FATMA VISAL
AU  - ÇETİNKAYA, Duygu
AU  - CEVHER ZEYTIN, inci
AU  - Karakaya, Jale
DO  - 10.4274/tjh.galenos.2021.2021.0434
PY  - 2022
JO  - Turkish Journal of Hematology
VL  - 39
IS  - 1
SN  - 1300-7777
SP  - 61
EP  - 65
DB  - TRDizin
UR  - http://search/yayin/detay/522068
ER  -