TY  - JOUR
TI  - DESIGN ALGINATE BASED BLENDS FOR LIVING COMPOSITE FIBERS TO PROMOTE 
WOUND HEALING
AB  - The currently used approaches in the treatment of wounds and burns have been studied for many years to eliminate problems 
related with mechanical strength, elasticity, biocompatibility and cost. Nowadays, fabrication of composite fibers by a fiber 
as core and hydrogels as shell, which can be seeded by cells is rapidly increasing. In this study, it is aimed to produce a 
natural polymer-based dressing that can provide controlled antibiotic release to accelerate wound healing with low cost and 
high efficiency. The composites have been achieved by using surgical suture as a core and alginate in the shell part, which 
modified with starch and gelatin. Evaluating low-cost hydrogel material such as alginate, starch and gelatin in the shell layer 
of composite fibers by different concentrations were investigated in addition to study their swelling and drug release 
behaviors. The parameters for the model of an antibiotic release that can prevent common infections can be manipulated by 
using a biotextile-based approach to quantify the amount of antibiotics and its release to satisfy clinical requirements.
Toluidine blue and Penicillin/Streptomycin were chosen as antibiotic models for drug release experiments. Moreover, human 
adipose tissue-derived mesenchymal stem cells (hAT-MSCs) were applied to evaluate cell viability experiments. Results 
demonstrated that alginate modified starch and gelatin can be used as low-cost and promisingmaterials for use in biomedical
applications.
AU  - EBRAHIMI, Aliakbar
AU  - OZKURT, METE
AU  - APAYDIN, Elif
AU  - Ozel, Ceren
AU  - Avci, Huseyin
AU  - Ghorbanpoor, Hamed
AU  - Uysal, Onur
AU  - EKER SARIBOYACI, AYLA
AU  - SENGEL, Tayfun
DO  - 10.18038/estubtda.984324
PY  - 2021
JO  - Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering
VL  - 22
IS  - -Vol:22- 8th ULPAS - Special Issue 2021
SN  - 2667-4211
SP  - 98
EP  - 111
DB  - TRDizin
UR  - http://search/yayin/detay/522325
ER  -