TY  - JOUR
TI  - Anaphylaxis to levetiracetam in an adolescent: a very rare
occurence
AB  - Background. Antiepileptic drugs (AEDs) are among the most common causes of severe delayed-type
hypersensitivity reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and Drug
Reaction with Eosinophilia and Systemic Symptoms(DRESS) in children. These reactions are more commonly
seen with aromatic AEDs such as phenytoin and carbamazepine than the non-aromatic or new generation
AEDs. However immediate-type hypersensitivity reactions such as urticaria/angioedema, anaphylaxis are very
rare with AEDs.
Case. Levetiracetam is an increasingly used new non-aromatic antiepileptic drug and reported to have a better
safety profile in daily practice. We present the first adolescent case who developed an anaphylactic reaction
with intravenous levetiracetam, not reported in this age group before in the literature.
Conclusion. Hypersensitivity reactions in the form of anaphylaxis can be rarely observed with new generation
AEDs. Therefore, when any antiepileptic drug is started on any patient, immediate type serious reactions such
as anaphylaxis should be kept in mind, not only focusing on delayed reactions such as SJS, TEN,or DRESS 
AU  - DERİNOZ GULERYUZ, OKSAN
AU  - ARHAN, Ebru
AU  - DEĞERMENCİ, Şeyda
AU  - BAKIRTAŞ, Arzu
AU  - Menderes, Deniz
AU  - ERTOY KARAGÖL, Hacer İlbilge
AU  - OKTAY, Mehmet Ali
AU  - KAHRAMAN, Şeyma
DO  - 10.24953/turkjped.2021.03.019
PY  - 2021
JO  - Turkish Journal of Pediatrics
VL  - 63
IS  - 3
SN  - 0041-4301
SP  - 506
EP  - 509
DB  - TRDizin
UR  - http://search/yayin/detay/522366
ER  -