TY  - JOUR
TI  - Comparison of Risk Scoring Systems in HLA-Matched Related
Allogeneic Hematopoietic Stem Cell Transplantation:
A Retrospective Cohort Study
AB  - Objective: Allogeneic hematopoietic stem cell transplantation (AHSCT)
is a potentially curative treatment of choice for many hematological
diseases. However, there are some transplantation-related risks.
Predicting the risk-benefit ratio prior to AHSCT facilitates the choice
of conditioning regimens and posttransplant follow-up. Hence, many
risk models have been developed. The aim of the present study was to
compare 6 different risk models that are clinically used.
Materials and Methods: A total of 259 patients were enrolled in this
study. The European Society for Blood and Marrow Transplantation
(EBMT), Hematopoietic Cell Transplantation Comorbidity Index
(HCT-CI), Age-Adjusted Hematopoietic Cell Transplantation
Comorbidity Index (HCT-CI-Age), revised Pretransplant Assessment of
Mortality (rPAM), Acute Leukemia-EBMT (AL-EBMT), and Disease Risk
Index (DRI) risk models were applied retrospectively.
Results: The AL-EBMT, HCT-CI, and HCT-CI-Age scoring systems were
found to be predictive for 2-year overall survival (OS) and 2-year
non-relapse mortality (NRM) (2-year OS: AL-EBMT, reference vs.
score 8.5-10, HR: 1.3, p=0.035; AL-EBMT, reference vs. score >10, HR:
3.8, p=0.001; HCT-CI: reference vs. score 1-2, HR: 1.4, p=0.018; HCT-
CI: reference vs. score ≥3, HR: 2.5, p<0.001; HCT-CI-Age: reference
vs. score 1-2, HR: 1.3, p<0.001; HCT-CI-Age: reference vs. score ≥3,
HR: 3.2, p<0.001) (2-year NRM: AL-EBMT: reference vs. score 8.5-10,
HR: 1.61, p<0.001; AL-EBMT: reference vs. score >10, HR: 3.3, p<0.001;
HCT-CI: reference vs. score 1-2, HR: 1.3, p=0.028; HCT-CI: reference
vs. score ≥3, HR: 2.3, p=0.011; HCT-CI-Age: reference vs. score 1-2,
HR: 1.3, p=0.01; HCT-CI-Age: reference vs. score ≥3, HR: 2.4, p=0.003).
In terms of the Kaplan-Meier estimates of 2-year OS and 2-year NRM,
the risk scoring system with the highest predictive power was found
to be AL-EBMT (2-year AUC: 0.59 and 0.60, respectively). The other
scores were not found to be predictive for 2-year OS and NRM.
Conclusion: In the present study at our bone marrow and stem cell
transplant center, it has been demonstrated that the HCT-CI, HCT-CI-
Age, and AL-EBMT are good predictors of 2-year NRM and OS.
AU  - Demiroglu, Haluk
AU  - Aladag, Elifcan
AU  - GOKER, ALI HAKAN
AU  - BÜYÜKAŞIK, Yahya
DO  - 10.4274/tjh.galenos.2020.2020.0178
PY  - 2021
JO  - Turkish Journal of Hematology
VL  - 38
IS  - 2
SN  - 1300-7777
SP  - 138
EP  - 144
DB  - TRDizin
UR  - http://search/yayin/detay/522466
ER  -