A review of the efficacy of intraarticular hip injection for
patients with hip osteoarthritis: To inject or not to inject in
hip osteoarthritis?

Tokgöz, Mehmet Ali; RAMPAL, Sanjiv; MOHADDES, Maziar; ZAZALI, Syafiqah Binti; JAIMAN, Ashish; ARUMUGAM, Gayathri; SIVANANTHAN, Sureshan; SINGH, Rashdeep Singh Jagdeb

doi:10.52312/jdrs.2022.402

A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?

Sanjiv RAMPAL, (University Putra Malaysia, Faculty of Medical and Health Sciences, Department of Orthopaedics, Serdang, Malaysia)

Ashish JAIMAN, (Vardhman Mahavir Medical College and Safdarjung Hospital, Central Institute of Orthopaedics, New Delhi, India)

Mehmet Ali TOKGÖZ, (Gazi Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Ankara, Türkiye)

Gayathri ARUMUGAM, (Hospital Port Dickson, Department of Orthopaedics, Negeri Sembilan, Malaysia)

Sureshan SIVANANTHAN, (Alty Orthopaedic Hospital, Department of Orthopaedics, Kuala Lumpur, Malaysia)

Rashdeep Singh Jagdeb SINGH, (Miri General Hospital, Department of Orthopaedics, Miri, Malaysia)

Syafiqah Binti ZAZALI, (University Putra Malaysia, Faculty of Medical and Health Sciences, Department of Orthopaedics, Serdang, Malaysia)

Maziar MOHADDES (University of Gothenburg, Institute of Clinical Science, Department of Orthopaedics, Sahlgrenska Academy, Gothenburg, Sweden)

Joint diseases and related surgery

7 0

Yıl: 2022 Cilt: 33 Sayı: 1 Sayfa Aralığı: 255 - 262 Metin Dili: İngilizce DOI: 10.52312/jdrs.2022.402 İndeks Tarihi: 21-06-2022

A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?

Öz:

Hip injection (HI) for osteoarthritis (OA) are in vogue nowadays. Corticosteroids (CSs) and hyaluronic acid (HA) gel are the two most common agents injected into the hip. Off late, platelet-rich plasma (PRP), mesenchymal stem cell (MSC), bone marrow aspirate concentrate (BMAC), local anesthetic (LA) agents, non-steroidal anti-inflammatory drugs (NSAIDs) and their different combinations have also been injected in hips to provide desired pain relief. However, there is a group of clinicians who vary of these injections. A search of the literature was performed on PubMed, Cochrane Library, and DOAJ using the keywords “hip osteoarthritis injection”. Data were analyzed and compiled. Intraarticular CSs are effective in providing the desired pain relief in OA hip, but repeated injections should be avoided and the interval between HI and hip arthroplasty must be kept for more than three months. Methylprednisolone or triamcinolone are combined with 1% lidocaine or 0.5% bupivacaine. Chondrotoxic effects of LA is a concern. Although national guidelines do not favor the use of HA for hip OA, numerous publications have favored its usage for a moderate grade of OA. The PRP, MSC, and BMAC are treatment options with great potential; however, currently, the evidence is conflicting on their role in hip OA. There is always a risk of septic arthritis, particularly when aseptic precautions are not followed, and clinicians must vary of this complication.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Urits I, Orhurhu V, Powell J, Murthy A, Kiely B, Shipon S, et al. Minimally invasive therapies for osteoarthritic hip pain: A comprehensive review. Curr Pain Headache Rep 2020;24:37.
2. Pereira LC, Kerr J, Jolles BM. Intra-articular steroid injection for osteoarthritis of the hip prior to total hip arthroplasty: Is it safe? A systematic review. Bone Joint J 2016;98-B:1027-35.
3. Quinn RH, Murray J, Pezold R, Hall Q. Management of osteoarthritis of the hip. J Am Acad Orthop Surg 2018;26:e434-e436.
4. Pogliacomi F, Schiavi P, Paraskevopoulos A, Leigheb M, Pedrazzini A, Ceccarelli F, et al. When is indicated viscosupplementation in hip osteoarthritis? Acta Biomed 2018;90:67-74.
5. McCabe PS, Maricar N, Parkes MJ, Felson DT, O'Neill TW. The efficacy of intra-articular steroids in hip osteoarthritis: A systematic review. Osteoarthritis Cartilage 2016;24:1509-17.
6. Gazendam A, Ekhtiari S, Bozzo A, Phillips M, Bhandari M. Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain: A systematic review and network meta-analysis of randomised controlled trials. Br J Sports Med 2021;55:256-61.
7. Dodré E, Lefebvre G, Cockenpot E, Chastanet P, Cotten A. Interventional MSK procedures: The hip. Br J Radiol 2016;89:20150408.
8. Crowe HW. Osteo-arthritis of the hip-joint treated by intraarticular injections. Proc R Soc Med 1947;40:486-7.
9. Leveaux VM, Quin CE. Local injection of hydrocortisone and procaine in osteo-arthritis of the hip joint. Ann Rheum Dis 1956;15:330-7.
10. American Academy of Orthopaedic Surgeons, Management of Osteoarthritis of the Hip Evidence-Based Clinical Practice Guideline. 2017. Available from: https://www.aaos.org/ globalassets/quality-and-practice-resources/osteoarthritisof- the-hip/oa-hip-cpg_6-11-19.pdf/ [Accessed: March 13, 2020]
11. Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: Current understanding with therapeutic implications. Arthritis Res Ther 2017;19:18.
12. Caldwell JR. Intra-articular corticosteroids. Guide to selection and indications for use. Drugs 1996;52:507-14.
13. Kullenberg B, Runesson R, Tuvhag R, Olsson C, Resch S. Intraarticular corticosteroid injection: Pain relief in osteoarthritis of the hip? J Rheumatol 2004;31:2265-8.
14. Qvistgaard E, Christensen R, Torp-Pedersen S, Bliddal H. Intra-articular treatment of hip osteoarthritis: A randomized trial of hyaluronic acid, corticosteroid, and isotonic saline. Osteoarthritis Cartilage 2006;14:163-70.
15. Dietrich TJ, Sutter R, Froehlich JM, Pfirrmann CW. Particulate versus non-particulate steroids for lumbar transforaminal or interlaminar epidural steroid injections: An update. Skeletal Radiol 2015;44:149-55.
16. Rastogi AK, Davis KW, Ross A, Rosas HG. Fundamentals of joint injection. AJR Am J Roentgenol 2016;207:484-94.
17. Lai WC, Arshi A, Wang D, Seeger LL, Motamedi K, Levine BD, et al. Efficacy of intraarticular corticosteroid hip injections for osteoarthritis and subsequent surgery. Skeletal Radiol 2018;47:1635-40.
18. Deshmukh AJ, Panagopoulos G, Alizadeh A, Rodriguez JA, Klein DA. Intra-articular hip injection: Does pain relief correlate with radiographic severity of osteoarthritis? Skeletal Radiol 2011;40:1449-54.
19. Wall C, Johnson T, de Steiger R. Symptom management for patients awaiting joint replacement surgery. Aust J Gen Pract 2020;49:444-6.
20. Hunter DJ. Viscosupplementation for osteoarthritis of the knee. N Engl J Med 2015;372:1040-7.
21. Eymard F, Maillet B, Lellouche H, Mellac-Ducamp S, Brocq O, Loeuille D, et al. Predictors of response to viscosupplementation in patients with hip osteoarthritis: Results of a prospective, observational, multicentre, openlabel, pilot study. BMC Musculoskelet Disord 2017;18:3.
22. Wu B, Li YM, Liu YC. Efficacy of intra-articular hyaluronic acid injections in hip osteoarthritis: A meta-analysis of randomized controlled trials. Oncotarget 2017;8:86865-76.
23. Basedow M, Williams H, Shanahan EM, Runciman WB, Esterman A. Australian GP management of osteoarthritis following the release of the RACGP guideline for the nonsurgical management of hip and knee osteoarthritis. BMC Res Notes 2015;8:536.
24. Dong Y, Zhang B, Yang Q, Zhu J, Sun X. The effects of platelet-rich plasma injection in knee and hip osteoarthritis: A meta-analysis of randomized controlled trials. Clin Rheumatol 2021;40:263-77.
25. Battaglia M, Guaraldi F, Vannini F, Rossi G, Timoncini A, Buda R, et al. Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis. Orthopedics 2013;36:e1501-8.
26. Di Sante L, Villani C, Santilli V, Valeo M, Bologna E, Imparato L, et al. Intra-articular hyaluronic acid vs plateletrich plasma in the treatment of hip osteoarthritis. Med Ultrason 2016;18:463-8.
27. Sezgin EA, Atik OŞ. Are orthobiologics the next chapter in clinical orthopedics? A literature review. Eklem Hastalik Cerrahisi 2018;29:110-6.
28. Atik OŞ. Do patients benefit from platelet-rich plasma? Jt Dis Relat Surg 2020;31:409-10.
29. Emadedin M, Ghorbani Liastani M, Fazeli R, Mohseni F, Moghadasali R, Mardpour S, et al. Long-term follow-up of intra-articular injection of autologous mesenchymal stem cells in patients with knee, ankle, or hip osteoarthritis. Arch Iran Med 2015;18:336-44.
30. Mardones R, Jofré CM, Tobar L, Minguell JJ. Mesenchymal stem cell therapy in the treatment of hip osteoarthritis. J Hip Preserv Surg 2017;4:159-63.
31. McIntyre JA, Jones IA, Han B, Vangsness CT Jr. Intraarticular mesenchymal stem cell therapy for the human joint: A systematic review. Am J Sports Med 2018;46:3550-63.
32. Kraeutler MJ, Chahla J, LaPrade RF, Pascual-Garrido C. Biologic options for articular cartilage wear (platelet-rich plasma, stem cells, bone marrow aspirate concentrate). Clin Sports Med 2017;36:457-68.
33. Rodriguez-Fontan F, Piuzzi NS, Kraeutler MJ, Pascual- Garrido C. Early clinical outcomes of intra-articular injections of bone marrow aspirate concentrate for the treatment of early osteoarthritis of the hip and knee: A cohort study. PM R 2018;10:1353-9.
34. Darrow M, Shaw B, Darrow B, Wisz S. Short-term outcomes of treatment of hip osteoarthritis with 4 bone marrow concentrate injections: A case series. Clin Med Insights Case Rep 2018;11:1179547618791574.
35. Park KD, Kim TK, Bae BW, Ahn J, Lee WY, Park Y. Ultrasound guided intra-articular ketorolac versus corticosteroid injection in osteoarthritis of the hip: A retrospective comparative study. Skeletal Radiol 2015;44:1333-40.
36. Gray RG, Gottlieb NL. Intra-articular corticosteroids. An updated assessment. Clin Orthop Relat Res 1983;(177):235-63.
37. Habib GS. Systemic effects of intra-articular corticosteroids. Clin Rheumatol 2009;28:749-56.
38. Raynauld JP, Buckland-Wright C, Ward R, Choquette D, Haraoui B, Martel-Pelletier J, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: A randomized, double-blind, placebocontrolled trial. Arthritis Rheum 2003;48:370-7.
39. McAlindon TE, LaValley MP, Harvey WF, Price LL, Driban JB, Zhang M, et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: A randomized clinical trial. JAMA 2017;317:1967-75.
40. Werner BC, Cancienne JM, Browne JA. The timing of total hip arthroplasty after intraarticular hip injection affects postoperative infection risk. J Arthroplasty 2016;31:820-3.
41. Jayaram P, Kennedy DJ, Yeh P, Dragoo J. Chondrotoxic effects of local anesthetics on human knee articular cartilage: A systematic review. PM R 2019;11:379-400.
42. Wettstein M, Dienst M. Arthroscopy of the peripheral compartment of the hip. Operative Techniques in Orthopaedics 2005;15:225-30.
43. Hoeber S, Aly AR, Ashworth N, Rajasekaran S. Ultrasoundguided hip joint injections are more accurate than landmarkguided injections: A systematic review and meta-analysis. Br J Sports Med 2016;50:392-6.
44. Sofka CM, Saboeiro G, Adler RS. Ultrasound-guided adult hip injections. J Vasc Interv Radiol 2005;16:1121-3.
45. Smith J, Hurdle MF. Office-based ultrasound-guided intraarticular hip injection: Technique for physiatric practice. Arch Phys Med Rehabil 2006;87:296-8.
46. Wang Y, Wang S, Luan S, Yu S, Zheng Y, Ma C, et al. Accuracy and feasibility of ultrasound-guided intraarticular injection of the rat hip joint. Ultrasound Med Biol 2021;47:2936-40.
47. Goeller A, Pogarell T, May MS, Uder M, Dankerl P. Evaluation of CT-guided ultra-low-dose protocol for injection guidance in preparation of MR-arthrography of the shoulder and hip joints in comparison to conventional and low-dose protocols. Diagnostics (Basel) 2021;11:1835.
48. Atik OŞ. What are the expectations of an editor from a scientific article? Jt Dis Relat Surg 2020;31:597-8.

APA	RAMPAL S, JAIMAN A, Tokgöz M, ARUMUGAM G, SIVANANTHAN S, SINGH R, ZAZALI S, MOHADDES M (2022). A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. , 255 - 262. 10.52312/jdrs.2022.402
Chicago	RAMPAL Sanjiv,JAIMAN Ashish,Tokgöz Mehmet Ali,ARUMUGAM Gayathri,SIVANANTHAN Sureshan,SINGH Rashdeep Singh Jagdeb,ZAZALI Syafiqah Binti,MOHADDES Maziar A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. (2022): 255 - 262. 10.52312/jdrs.2022.402
MLA	RAMPAL Sanjiv,JAIMAN Ashish,Tokgöz Mehmet Ali,ARUMUGAM Gayathri,SIVANANTHAN Sureshan,SINGH Rashdeep Singh Jagdeb,ZAZALI Syafiqah Binti,MOHADDES Maziar A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. , 2022, ss.255 - 262. 10.52312/jdrs.2022.402
AMA	RAMPAL S,JAIMAN A,Tokgöz M,ARUMUGAM G,SIVANANTHAN S,SINGH R,ZAZALI S,MOHADDES M A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. . 2022; 255 - 262. 10.52312/jdrs.2022.402
Vancouver	RAMPAL S,JAIMAN A,Tokgöz M,ARUMUGAM G,SIVANANTHAN S,SINGH R,ZAZALI S,MOHADDES M A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. . 2022; 255 - 262. 10.52312/jdrs.2022.402
IEEE	RAMPAL S,JAIMAN A,Tokgöz M,ARUMUGAM G,SIVANANTHAN S,SINGH R,ZAZALI S,MOHADDES M "A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?." , ss.255 - 262, 2022. 10.52312/jdrs.2022.402
ISNAD	RAMPAL, Sanjiv vd. "A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?". (2022), 255-262. https://doi.org/10.52312/jdrs.2022.402

APA	RAMPAL S, JAIMAN A, Tokgöz M, ARUMUGAM G, SIVANANTHAN S, SINGH R, ZAZALI S, MOHADDES M (2022). A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. Joint diseases and related surgery, 33(1), 255 - 262. 10.52312/jdrs.2022.402
Chicago	RAMPAL Sanjiv,JAIMAN Ashish,Tokgöz Mehmet Ali,ARUMUGAM Gayathri,SIVANANTHAN Sureshan,SINGH Rashdeep Singh Jagdeb,ZAZALI Syafiqah Binti,MOHADDES Maziar A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. Joint diseases and related surgery 33, no.1 (2022): 255 - 262. 10.52312/jdrs.2022.402
MLA	RAMPAL Sanjiv,JAIMAN Ashish,Tokgöz Mehmet Ali,ARUMUGAM Gayathri,SIVANANTHAN Sureshan,SINGH Rashdeep Singh Jagdeb,ZAZALI Syafiqah Binti,MOHADDES Maziar A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. Joint diseases and related surgery, vol.33, no.1, 2022, ss.255 - 262. 10.52312/jdrs.2022.402
AMA	RAMPAL S,JAIMAN A,Tokgöz M,ARUMUGAM G,SIVANANTHAN S,SINGH R,ZAZALI S,MOHADDES M A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. Joint diseases and related surgery. 2022; 33(1): 255 - 262. 10.52312/jdrs.2022.402
Vancouver	RAMPAL S,JAIMAN A,Tokgöz M,ARUMUGAM G,SIVANANTHAN S,SINGH R,ZAZALI S,MOHADDES M A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?. Joint diseases and related surgery. 2022; 33(1): 255 - 262. 10.52312/jdrs.2022.402
IEEE	RAMPAL S,JAIMAN A,Tokgöz M,ARUMUGAM G,SIVANANTHAN S,SINGH R,ZAZALI S,MOHADDES M "A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?." Joint diseases and related surgery, 33, ss.255 - 262, 2022. 10.52312/jdrs.2022.402
ISNAD	RAMPAL, Sanjiv vd. "A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?". Joint diseases and related surgery 33/1 (2022), 255-262. https://doi.org/10.52312/jdrs.2022.402