TY  - JOUR
TI  - Young age and shorter duration of Crohn’s disease are
associated with non-adherence to taking medication
AB  - OBJECTIVE: The mainstay of Crohn’s disease treatment is medical therapy. Failure to comply with medications causes disease
activation, loss of response to treatment, and increased hospitalization rates. Drug non-adherence worsens the course
of the disease, leading to fistula, stricture, and surgical interventions. The adherence rates to drug therapy in Crohn’s disease
patients and the risk factors vary considerably in the literature. The aim of the study was to investigate drug adherence rates
and factors affecting adherence to Crohn’s disease medications.
METHODS: This study was conducted as prospective cohort study at the tertiary health care institution inflammatory bowel
disease outpatient clinic within 1 year. Crohn’s disease characteristics and pharmacy records of consecutive patients were
evaluated. Medication adherence was assessed by calculating the medication possession ratio using the amount of medication
purchased from the pharmacy.
RESULTS: A total of 129 patients were included in the study. It was observed that 43.6% of the patients did not comply with
their Crohn’s disease medications. It was determined that the patients who did not adhere to the medication were significantly
younger (41±12 vs. 48±13, p=0.039). The duration of the disease is shorter in patients who did not comply with the drugs
(4.50 [IQR: 3.00–12.00] vs. 6.00 [IQR: 3.00–12.00, p=0.025]). Adherence with medication is lower in patients with higher
education levels (35.7% vs. 64.3%, p=0.023).
CONCLUSION: Medication adherence is of critical importance for Crohn’s disease outcomes. Nearly half of Crohn’s disease
patients do not comply with drugs. Young and highly educated patients with shorter disease duration should be targeted for
measures to increase the rates of medication adherence.
AU  - YILMAZ, HASAN
DO  - 10.14744/nci.2021.08634
PY  - 2022
JO  - İstanbul Kuzey Klinikleri
VL  - 9
IS  - 1
SN  - 2148-4902
SP  - 8
EP  - 13
DB  - TRDizin
UR  - http://search/yayin/detay/522546
ER  -