Treating acute stroke in the early period can lead to reperfusion and minimize the loss of neurological function. In this study, our aim is to analyze the prognosis of our patients who underwent intravenous thrombolytic and/or mechanical interventional treatment in the last one year in our newly opened stroke center and evaluate our clinical experience. A total of 166 patients with a mean age of 68.7±11.3 who underwent intravenous r-tPA ± mechanical thrombectomy in our stroke center were included in the study. The mean time from symptom-to-door was 138.6±48.3 min, and the mean NIHSS score on admission was 10.9±4.1. Intravenous r-tPA was preferred for treatment in 59.6% (99) patients. The mortality rate was 25.3% (42) for all patients. The mortality rate was 15.1% (15/99) for patients receiving intravenous r-tPA, and based on this finding, the mortality risk was found to be significantly higher in patients who did not receive intravenous r-tPA (p < 0.001). The mortality rate was 40% (6/15) for patients undergoing only mechanical thrombectomy (p: 0.145). The mRS score of the patients who received intravenous r-tPA was 3.18 in the first month, whereas the score of the patients who did not receive intravenous r-tPA was 3.74 (p:0.010). As a result, mortality and sequelae rates have been significantly reduced with the use of thrombolytic therapy and interventional neurovascular procedures. Although our center is newly opened, it shows promise for the upcoming years.