TY  - JOUR
TI  - Levels of obestatin in euthyroid patients receiving
levothyroxine replacement therapy
AB  - To investigate the relationship between obestatin and TSH levels in patients who received thyroid hormone replacement and were in the euthyroid state. Included 30 patients
who were followed up in the endocrinology outpatient clinic in 2020, who received L-thyroxine replacement, and 30 healthy individuals without any chronic disease
who did not receive thyroid hormone replacement. Blood samples were taken from both groups for obestatin, thyroid-stimulating hormone (TSH) and free T4 hormone
(fT4) levels. There is significant difference in TSH levels (p = 0.007) was found between the two groups. The obestatin levels of the L-thyroxine replacement group were
lower than those of the control group (p = 0.001). No correlation was observed between the TSH and obestatin levels in the control and L-thyroxine replacement groups. In
this study, obestatin levels were significantly lower in patients who received L-thyroxine replacement therapy and were in euthyroid status than those in the control group.
No correlation was found between obestatin and TSH levels in the control and patient groups. As a result of this study, the thyroid gland may play a more important role
in the synthesis or regulation of obestatin synthesis beyond our current knowledge.
AU  - Ozturk, Nurinnisa
AU  - Mercantepe, Filiz
AU  - çiftel, serpil
AU  - ÇAPOĞLU, İLYAS
AU  - DAYANAN, RAMAZAN
AU  - ÇİFTEL, Enver çiftel
AU  - Bilen, Arzu
AU  - bilen, habib
DO  - 10.5455/medscience.2021.09.280
PY  - 2022
JO  - Medicine Science
VL  - 11
IS  - 1
SN  - 2147-0634
SP  - 131
EP  - 134
DB  - TRDizin
UR  - http://search/yayin/detay/522730
ER  -