TY  - JOUR
TI  - Bis benzothiophene Schiff bases: synthesis and in silico-guided biological
activity studies
AB  - Since benzo [ b ] thiophene scaffold is one of the privileged structures in drug discovery as this core exhibitsactivities for different biological problems, in this study bis (benzo[ b ]thiophene-2-yl) alkyl methanimine derivatives (1-9)
were synthesized by reacting benzo[ b ]thiophene-2-carbaldehyde with diamines. All newly compounds were characterized
by IR, $^{1}H$ NMR and $^{13} C NMR$ spectroscopic methods. Synthesized compounds were investigated using binary QSARbased models on therapeutic activity prediction of synthesized compounds and they showed high predicted activities in
following diseases: bacterial, angina, allergy, depression and obesity. Thus, they were then tested for their antimicrobial
and antileishmanial activities as a result of this theoretical study. Compound 1(N, N’- (propane-1,3-diyl) bis (1-(benzo
[ b ] thiophene-2-yl)) methanimine) was found the most active compound in both diseases. Thus, its molecular docking
studies were also carried out.
AU  - ÜNVER, YASEMİN
AU  - Durdagi, Serdar
AU  - Ünlüer, Dilek
AU  - Direkel, Şahin
DO  - 10.3906/kim-2004-78
PY  - 2020
JO  - Turkish Journal of Chemistry
VL  - 44
IS  - 4
SN  - 1300-0527
SP  - 1164
EP  - 1176
DB  - TRDizin
UR  - http://search/yayin/detay/522841
ER  -