Ultrasound-guided erector spinae plane (ESP) block is regional anesthesia technique for the management of thoracic and abdominal neuropathic pain. ESP block may also be a good option to provide postoperative analgesia. In this case report, we describe our experiences of ESP block used for postoperative analgesia in three patients undergoing laparoscopic-assisted percutaneous nephrolithotomy (PCNL), laparoscopic-assisted total abdominal hysterectomy (TAH), and a unilateral total mastectomy. In all three patients, ESP block provided effective analgesia and increased patient satisfaction according to their pain management scores (numerical rating scale [NRS]).