TY  - JOUR
TI  - Evaluation of Oxidative Stress, Immune System and Mineral 
Concentrations in Milk and Serum of Cows with Clinical and 
Subclinical Mastitis Naturally Infected by Staphylococcus aureus
AB  - The aim of this study was to investigate effect of Staphylococcus aureus on oxidative stress status (TAS, TOS, OSI), immune system (IL-1β, IL-6, TNF-α), 
and mineral (Mg, Fe, Zn, Cu, Na and Ca) concentrations in milk and serum of cows with mastitis. The cows were allocated to three groups according to 
mammary health status as follows: healthy (Group 1), clinical (Group 2) and subclinical mastitis cows (Group 3). IL-1β levels in serum and milk increased 
in Group 2 compared to Group 1 and Group 3 (P<0.001; P<0.05). Milk IL-6 level was greater in Group 3 and Group 2 than in Group 1 (P<0.01). Blood 
TNF-α (P<0.001), TOS and OSI levels (P<0.01) were higher in Group 2 than other groups. Milk TNF-α level increased and blood TAS level decreased in 
Group 2 compared to Group 1 (P<0.05). Milk TOS (P<0.01) and OSI (P<0.05) levels increased in Group 3 compared to Group 1. Blood and milk Mg levels 
increased in Group 1 (P<0.05) and Group 2 (P<0.001), respectively. Milk Fe (P<0.01) and Na levels were greater in Group 2 (P<0.001). Blood Zn level 
was lower in Group 2 compared to Group 3 (P<0.05). While blood Cu level decreased in Group 1 compared to other groups, milk Cu level decreased 
in Group 3 compared to other groups (P<0.001). In conclusion, S. aureus had significant effects on oxidative stress, cytokine and mineral levels in milk 
and blood serum of cows with clinical and subclinical mastitis. However, since there were specific changes only in milk OSI and IL-6 levels according 
to other parameters, it is thought that milk IL-6 and OSI levels may be a diagnostic tool in the detection of subclinical mastitis.
AU  - Demir, Pinar
AU  - Eski, Funda
AU  - mis, leyla
AU  - kurt, serdal
DO  - 10.9775/kvfd.2021.26281
PY  - 2021
JO  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
VL  - 27
IS  - 6
SN  - 1300-6045
SP  - 755
EP  - 762
DB  - TRDizin
UR  - http://search/yayin/detay/523002
ER  -