Evaluation of the mir-126, mir-182, and mir-486-5p 
Expression Signature of Head and Neck Squamous Cell 
Carcinomas and Lung Squamous Cell Carcinomas

Erkul, Evren; Gungor, Atila; KÜÇÜKODACI, ZAFER; YILMAZ, ISMAIL; TURAL, ERSİN; issin, gizem; YILDIRIM, SÜKRÜ; DEMIREL, DILAVER

doi:10.5146/tjpath.2021.01528

Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas

Gizem ISSIN, (Erzincan Binali Yıldırım Üniversitesi, Mengücek Gazi Eğitim ve Araştırma Hastanesi, Patoloji Anabilim Dalı, ERZINCAN, TÜRKİYE)

Zafer KÜÇÜKODACI, (Sağlık Bilimleri Üniversitesi, İstanbul Sultan 2. Abdülhamid Han Eğitim Hastanesi, Patoloji Anabilim Dalı, İSTANBUL, TÜRKİYE)

İsmail YILMAZ, (Sağlık Bilimleri Üniversitesi, İstanbul Sultan 2. Abdülhamid Han Eğitim Hastanesi, Patoloji Anabilim Dalı, İSTANBUL, TÜRKİYE)

Evren ERKUL, (Gülhane Tıp Fakültesi, Sağlık Bilimleri Üniversitesi, Kulak Burun Boğaz Anabilim Dalı, İstanbul Sultan 2. Abdülhamid Han Eğitim Hastanesi, İSTANBUL, TÜRKİYE)

Ersin TURAL, (Sağlık Bilimleri Üniversitesi, İstanbul Sultan 2. Abdülhamid Han Eğitim Hastanesi, Pediatri Anabilim Dalı, İSTANBUL, TÜRKİYE)

Dilaver DEMIREL, (Sağlık Bilimleri Üniversitesi, Gaziosmanpaşa-Taksim Sağlık Uygulama ve Araştırma Merkezi, Patoloji Anabilim Dalı, İSTANBUL, TÜRKİYE)

Atila GUNGOR, (Medical Park Göztepe Hastanesi, Kulak Burun Boğaz Anabilim Dalı, İSTANBUL, TÜRKİYE)

Sukru YILDIRIM (Maltepe Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, İSTANBUL, TÜRKİYE)

Türk Patoloji Dergisi

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Yıl: 2021 Cilt: 37 Sayı: 2 Sayfa Aralığı: 106 - 114 Metin Dili: İngilizce DOI: 10.5146/tjpath.2021.01528 İndeks Tarihi: 22-06-2022

Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas

Öz:

Objective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal SCCs in 40 patients, using quantitative real-time polymerase chain reaction. Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization. Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. miRNA expression analysis can be used to predict the primary localizations of those SCCs.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	issin g, KÜÇÜKODACI Z, YILMAZ I, Erkul E, TURAL E, DEMIREL D, Gungor A, YILDIRIM S (2021). Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. , 106 - 114. 10.5146/tjpath.2021.01528
Chicago	issin gizem,KÜÇÜKODACI ZAFER,YILMAZ ISMAIL,Erkul Evren,TURAL ERSİN,DEMIREL DILAVER,Gungor Atila,YILDIRIM SÜKRÜ Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. (2021): 106 - 114. 10.5146/tjpath.2021.01528
MLA	issin gizem,KÜÇÜKODACI ZAFER,YILMAZ ISMAIL,Erkul Evren,TURAL ERSİN,DEMIREL DILAVER,Gungor Atila,YILDIRIM SÜKRÜ Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. , 2021, ss.106 - 114. 10.5146/tjpath.2021.01528
AMA	issin g,KÜÇÜKODACI Z,YILMAZ I,Erkul E,TURAL E,DEMIREL D,Gungor A,YILDIRIM S Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. . 2021; 106 - 114. 10.5146/tjpath.2021.01528
Vancouver	issin g,KÜÇÜKODACI Z,YILMAZ I,Erkul E,TURAL E,DEMIREL D,Gungor A,YILDIRIM S Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. . 2021; 106 - 114. 10.5146/tjpath.2021.01528
IEEE	issin g,KÜÇÜKODACI Z,YILMAZ I,Erkul E,TURAL E,DEMIREL D,Gungor A,YILDIRIM S "Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas." , ss.106 - 114, 2021. 10.5146/tjpath.2021.01528
ISNAD	issin, gizem vd. "Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas". (2021), 106-114. https://doi.org/10.5146/tjpath.2021.01528

APA	issin g, KÜÇÜKODACI Z, YILMAZ I, Erkul E, TURAL E, DEMIREL D, Gungor A, YILDIRIM S (2021). Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. Türk Patoloji Dergisi, 37(2), 106 - 114. 10.5146/tjpath.2021.01528
Chicago	issin gizem,KÜÇÜKODACI ZAFER,YILMAZ ISMAIL,Erkul Evren,TURAL ERSİN,DEMIREL DILAVER,Gungor Atila,YILDIRIM SÜKRÜ Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. Türk Patoloji Dergisi 37, no.2 (2021): 106 - 114. 10.5146/tjpath.2021.01528
MLA	issin gizem,KÜÇÜKODACI ZAFER,YILMAZ ISMAIL,Erkul Evren,TURAL ERSİN,DEMIREL DILAVER,Gungor Atila,YILDIRIM SÜKRÜ Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. Türk Patoloji Dergisi, vol.37, no.2, 2021, ss.106 - 114. 10.5146/tjpath.2021.01528
AMA	issin g,KÜÇÜKODACI Z,YILMAZ I,Erkul E,TURAL E,DEMIREL D,Gungor A,YILDIRIM S Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. Türk Patoloji Dergisi. 2021; 37(2): 106 - 114. 10.5146/tjpath.2021.01528
Vancouver	issin g,KÜÇÜKODACI Z,YILMAZ I,Erkul E,TURAL E,DEMIREL D,Gungor A,YILDIRIM S Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas. Türk Patoloji Dergisi. 2021; 37(2): 106 - 114. 10.5146/tjpath.2021.01528
IEEE	issin g,KÜÇÜKODACI Z,YILMAZ I,Erkul E,TURAL E,DEMIREL D,Gungor A,YILDIRIM S "Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas." Türk Patoloji Dergisi, 37, ss.106 - 114, 2021. 10.5146/tjpath.2021.01528
ISNAD	issin, gizem vd. "Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas". Türk Patoloji Dergisi 37/2 (2021), 106-114. https://doi.org/10.5146/tjpath.2021.01528