TY  - JOUR
TI  - Evaluation of the mir-126, mir-182, and mir-486-5p 
Expression Signature of Head and Neck Squamous Cell 
Carcinomas and Lung Squamous Cell Carcinomas
AB  - Objective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance 
under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and 
mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. 
Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal 
SCCs in 40 patients, using quantitative real-time polymerase chain reaction. 
Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression 
profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization. 
Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. 
miRNA expression analysis can be used to predict the primary localizations of those SCCs.
AU  - Erkul, Evren
AU  - Gungor, Atila
AU  - KÜÇÜKODACI, ZAFER
AU  - YILMAZ, ISMAIL
AU  - TURAL, ERSİN
AU  - issin, gizem
AU  - YILDIRIM, SÜKRÜ
AU  - DEMIREL, DILAVER
DO  - 10.5146/tjpath.2021.01528
PY  - 2021
JO  - Türk Patoloji Dergisi
VL  - 37
IS  - 2
SN  - 1018-5615
SP  - 106
EP  - 114
DB  - TRDizin
UR  - http://search/yayin/detay/523077
ER  -