TY  - JOUR
TI  - Novel immunohistochemical marker in the differential 
diagnosis of sex cord-stromal tumors: SF-1
AB  - Aim: Sex cord-stromal tumors are relatively uncommon tumors which constitute approximately 8% of all primary ovarian neoplasms. 
Morphologic differentiation of non-SCST from SCSTs can be challenging due to microscopic overlap. Immunohistochemistry is 
beneficial in challenging cases. Inhibin and calretinin have limited sensitivity and specificity, a more sensitive marker is required. 
SF-1 is known as a promising immunohistochemical marker in the differentiation of SCST from non-SCST ovarian tumors. For this 
purpose, various non-SCSTs (metastatic and non-metastatic) having morphologic overlap with SCSTs, and multiple SCSTs were 
stained with SF-1 antibody to elucidate its importance in morphologically challenging cases.
Materials and Methods: Twenty-three SCST, 40 non-SCSTs, and an ectopic adrenal tissue were stained with SF-1, and also the
percentage and the intensity were scored. SF-1 immunoreactivity was seen in all 23 SCST with varying degrees of intensity and 
percentage. In contrast, non-SCSTs were negative in all
regarding to SF-1. Ectopic adrenal gland tissue and ovarian stroma are positive as non-tumoral lesions.
Results: In our series, SF-1 immunoreactivity was seen in all 23 SCST and ectopic adrenal tissue with varying degrees of intensity 
and diffuseness. In contrast, non-SCSTs were all negative concerning SF-1. In addition; we observed nuclear positivity with SF-1 in 
15-75% of the sclerosing stromal tumor cells, whereas inhibin and calretinin were negative in all 4 cases.
Conclusion: Our data shows that SF-1 is a nuclear, reliable and surrogate marker for all SCSTs, and can be used routinely.
AU  - ALPASLAN, ASLIHAN
AU  - USUBÜTÜN, Alp
AU  - Ates, Deniz
AU  - tuncel daloglu, ferah
DO  - 10.5455/annalsmedres.2021.03.277
PY  - 2022
JO  - Annals of Medical Research
VL  - 29
IS  - 1
SN  - 2636-7688
SP  - 36
EP  - 40
DB  - TRDizin
UR  - http://search/yayin/detay/523839
ER  -